Nanocomposites in Combating Antimicrobial Resistance

Title

Nanocomposites in Combating Antimicrobial Resistance

Creator

Varghese M.; Mathew A.A.; Balachandran M.

Description

Extensive and improper usage of antibiotics has resulted in the outbreak of multidrugresistant microorganisms and increasing antimicrobial resistance (AMR), which has become a significant threat to global health and health care. Resistant microorganisms adapt various resistance mechanisms like modifying the structure of antibiotics, altering the target, inhibiting the internalization of antibiotics, ejection of antibiotics from bacterial cells, etc. By lowering or completely disabling the efficacy of antibiotics, AMR may become a primary cause of mortality if left unattended. Developing effective antiresistance strategies to combat AMR is an urgent need of time. Nanomaterials have great potential to inactivate pathogens, and their mechanism of antimicrobial activity is different from antibiotics. With these unique mechanisms of antimicrobial action, nanomaterials are less prone to develop AMR. Developing nanocomposites can provide synergistic effects to improve the properties and strengthen the antimicrobial capability of individual nanomaterials. In this chapter, contemporary developments in the application of antimicrobial composites such as carbon nanocomposites, metallic nanocomposites, nonmetallic nanocomposites, metalloid nanocomposites, polymer nanocomposites, ceramic nanocomposites, and their hybrid forms to prevent the evolution of AMR will be discussed. The current research direction, prospects, and possible strategies to explore nanocomposites as potent antimicrobial agents to conquer AMR will be highlighted. The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.

Source

Nanotechnology Based Strategies for Combating Antimicrobial Resistance, pp. 203-230.

Date

2024-01-01

Publisher

Springer Nature

Subject

AMR; Antibacterial; Nanocomposite; Synergistic effect

Coverage

Varghese M., Department of Physics and Electronics, CHRIST (Deemed to be University), Karnataka, Bengaluru, India; Mathew A.A., Department of Physics and Electronics, CHRIST (Deemed to be University), Karnataka, Bengaluru, India; Balachandran M., Department of Physics and Electronics, CHRIST (Deemed to be University), Karnataka, Bengaluru, India

Rights

Restricted Access

Relation

ISBN: 978-981972023-1; 978-981972022-4

Format

Online

Language

English

Type

Book chapter

Identifier

https://doi.org/10.1007/978-981-97-2023-1_8

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85205619308&doi=10.1007%2f978-981-97-2023-1_8&partnerID=40&md5=d8433c1ca45b3cb95a46464eeb856775