Exosomes as an emerging nanoplatform for functional therapeutics
- Title
- Exosomes as an emerging nanoplatform for functional therapeutics
- Creator
- Balasubramanian B.; Ahmad S.; Alok V.; Khan F.N.; Anand K.; Mehta S.; Easwaran M.; Meyyazhagan A.; Saravanan M.
- Description
- The release of a division of extracellular entities with 40-100 nm dimension from both tumor and varied mesenchymal stem cells during pathologic conditions is termed as exosomes that are shown to actively participate in chemical signaling events occurring in multicellular organisms infection. Exosomes act as a vehicle for shifting amino acids, lipids, and genetic components that are readily engulfed by far-flanging cells (or adjacent cells) at the site of release for remolding the receptor cell functions once the biological contents get activated. Furthermore, pathogens too display the dispense of exosomes to temper the hosts immune response and trigger the infection rate, making them apt investigation markers for diseases. Additionally, aiding in antigen presentation and immune response stimulation, exosomes are significant in showing contrasting role as initiating anticarcinogenic responses and involving in promoting tumorigenesis as they are released from tumor cells. Due to their site specificity, cell lineage property, and encapsulation of specific constituents, exosomes can be potentially utilized as a precious investigatory and prognostic tool along with a possible carrier of drugs and gene shipment for curative goal. Since exosome groundwork is at the infancy stage, deeper insight is required to know its composition, formation, and targeting mechanism along with its significant role in disease diagnosis and treatment. This states, as mentioned previously, we have tried to focus solely on the functional and clinical implications of exosomes in-depth in this review. 2021 Elsevier B.V. All rights reserved.
- Source
- Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications, pp. 483-498.
- Date
- 2021-01-01
- Publisher
- Elsevier
- Subject
- Databases; ELISA; Exosomes; Markers; Quantification; Vesicles
- Coverage
- Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, South Korea; Ahmad S., Department of Computer Science, Jamia Millia Islamia University, New Delhi, India, Agriculture Knowledge Management Unit, ICAR-Indian Agricultural Research Institute, New Delhi, India; Alok V., Department of Computer Science, Jamia Millia Islamia University, New Delhi, India; Khan F.N., Department of Education in Science and Mathematics, National Council of Educational Research and Training, New Delhi, India; Anand K., Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences and National Health Laboratory Service, University of the Free State, Bloemfontein, South Africa; Mehta S., Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences and National Health Laboratory Service, University of the Free State, Bloemfontein, South Africa; Easwaran M., International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India; Meyyazhagan A., Department of Life Sciences, Christ (Deemed to be University), Karnataka, Bangalore, India; Saravanan M., Department of Medical Microbiology and Immunology, Institute of Bio-medical Sciences, College of Health Science, Mekelle University, Ethiopia, AMR and Nanomedicine Laboratory, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India
- Rights
- Restricted Access
- Relation
- ISBN: 978-012821013-0
- Format
- Online
- Language
- English
- Type
- Book chapter
Collection
Citation
Balasubramanian B.; Ahmad S.; Alok V.; Khan F.N.; Anand K.; Mehta S.; Easwaran M.; Meyyazhagan A.; Saravanan M., “Exosomes as an emerging nanoplatform for functional therapeutics,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/18757.