Sulphuric acid supported silica gel (H2SO4-SiO2) as an efficient catalyst for one-pot multicomponent synthesis of pyrano[2,3-c]pyrazol-amines under ultrasonication
- Title
- Sulphuric acid supported silica gel (H2SO4-SiO2) as an efficient catalyst for one-pot multicomponent synthesis of pyrano[2,3-c]pyrazol-amines under ultrasonication
- Creator
- Govindaraju S.; Tabassum S.
- Description
- In this study, the catalytic potential of a novel heterogeneous catalyst-sulphuric acid supported on silica gel (H2SO4-SiO2) has been assessed for the one-pot cyclo condensation reaction of aromatic aldehydes, 4-nitrophenylacetonitrile, ethyl acetoacetate and hydrazine/phenyl hydrazine to furnish poly functionalized pyrano[2,3-c]pyrazol-amine scaffolds under ultrasonication. Notably, within the framework of green chemistry, this divergent and step-economic approach has many benefits such as (i) use of water as solvent in the reaction, (ii) creation of up to five bonds in one sequence, (iii) avail of US irradiation as an efficient source of energy, (iv) application of nontoxic and reusable catalyst. Besides these, simple workup procedure, low catalyst loadings, shorter reaction time, high functional group compatibility, readily accessible starting materials and excellent yields without column chromatography render this protocol novel and greener towards the synthesis of poly functionalized pyrano[2,3-c]pyrazol-amines. 2020 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the Second International Symposium ''Functional Nanomaterials in Industrial Applications: Academy - Industry Meet''.
- Source
- Materials Today: Proceedings, Vol-45, pp. 3762-3768.
- Date
- 2020-01-01
- Publisher
- Elsevier Ltd
- Subject
- 3-c]pyrazol-amines; Four-component synthesis; H2SO4-SiO2 Pyrano[2; Multicomponent reaction; Ultrasonication
- Coverage
- Govindaraju S., Department of Sciences and Humanities, School of Engineering and Technology, CHRIST (Deemed to be University), Kumbalagodu, Mysore Road, Bengaluru, 560074, India; Tabassum S., Department of Chemistry, Surana College, South End Road, Basavanagudi, Bengaluru, 560004, India
- Rights
- Restricted Access
- Relation
- ISSN: 22147853
- Format
- Online
- Language
- English
- Type
- Conference paper
Collection
Citation
Govindaraju S.; Tabassum S., “Sulphuric acid supported silica gel (H2SO4-SiO2) as an efficient catalyst for one-pot multicomponent synthesis of pyrano[2,3-c]pyrazol-amines under ultrasonication,” CHRIST (Deemed To Be University) Institutional Repository, accessed April 21, 2025, https://archives.christuniversity.in/items/show/20731.