Cinnamon A Competent Drug: A Review on Extraction, Analysis and Anticancer Action

Title

Cinnamon A Competent Drug: A Review on Extraction, Analysis and Anticancer Action

Creator

Demina T.D.; Margaret Rodrigues R.; George L.; Varghese A.

Description

Cinnamon, an Indigenous species, is extensively used as a folk medicine in India, China, and other parts of the world due to its therapeutic potential inherited via the latent chemical composition. The vital component presented is cinnamaldehyde, along with cinnamic acid and cinnamate, which contributes to being an anti-inflammatory, antimicrobial, antidiabetic, and anticancer agent together with the capability to control neurological syndromes like Alzheimer's and even Parkinson's diseases. Given the importance of the anticarcinogenic properties of cinnamon on various cell strains concerning the curable effect, this review focuses on evaluating different extraction methods like steam distillation, Soxhlet extraction, microwave-assisted extraction, and more, in addition to a summary of new technologies like gas chromatography, HPLC, DART-MS, and NMR, etc. which paved the way in characterizing the chemical composition of cinnamon. Cinnamaldehyde showed its apoptosis through various mechanistic pathways on an adequate number of cell lines and antineoplastic potential on specific multifaceted cancerous cells, which advocates for continued research and investment in this vital area of drug discovery and suggestions for future scope. 2024 Wiley-VCH GmbH.

Source

ChemistrySelect, Vol-9, No. 41

Date

2024-01-01

Publisher

John Wiley and Sons Inc

Subject

Anticancer; Apoptosis; Cinnamon; Extraction; Microwave-assisted analysis

Coverage

Demina T.D., Department of Chemistry, CHRIST University, Hosur Road, Karnataka, Bengaluru, 560029, India; Margaret Rodrigues R., Department of Chemistry, CHRIST University, Hosur Road, Karnataka, Bengaluru, 560029, India, Department of Chemistry, St Agnes College (Autonomous), Karnataka, Mangaluru, 575002, India; George L., Department of Chemistry, CHRIST University, Hosur Road, Karnataka, Bengaluru, 560029, India; Varghese A., Department of Chemistry, CHRIST University, Hosur Road, Karnataka, Bengaluru, 560029, India

Rights

Restricted Access

Relation

ISSN: 23656549

Format

Online

Language

English

Type

Review

Identifier

https://doi.org/10.1002/slct.202401636

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85207904221&doi=10.1002%2fslct.202401636&partnerID=40&md5=5b9f814aacdccc91a24e8de249b9aa3c