Epigenetic Mechanisms Induced by Mycobacterium tuberculosis to Promote Its Survival in the Host
- Title
- Epigenetic Mechanisms Induced by Mycobacterium tuberculosis to Promote Its Survival in the Host
- Creator
- Thomas S.S.; Abhinand K.; Menon A.M.; Nair B.G.; Kumar G.B.; Arun K.B.; Edison L.K.; Madhavan A.
- Description
- Tuberculosis caused by the obligate intracellular pathogen, Mycobacterium tuberculosis, is one among the prime causes of death worldwide. An urgent remedy against tuberculosis is of paramount importance in the current scenario. However, the complex nature of this appalling disease contributes to the limitations of existing medications. The quest for better treatment approaches is driving the research in the field of host epigenomics forward in context with tuberculosis. The interplay between various host epigenetic factors and the pathogen is under investigation. A comprehensive understanding of how Mycobacterium tuberculosis orchestrates such epigenetic factors and favors its survival within the host is in increasing demand. The modifications beneficial to the pathogen are reversible and possess the potential to be better targets for various therapeutic approaches. The mechanisms, including histone modifications, DNA methylation, and miRNA modification, are being explored for their impact on pathogenesis. In this article, we are deciphering the role of mycobacterial epigenetic regulators on various strategies like cytokine expression, macrophage polarization, autophagy, and apoptosis, along with a glimpse of the potential of host-directed therapies. 2024 by the authors.
- Source
- International Journal of Molecular Sciences, Vol-25, No. 21
- Date
- 2024-01-01
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Subject
- apoptosis; autophagy; epigenetics; macrophage polarization; miRNA modification; tuberculosis
- Coverage
- Thomas S.S., School of Biotechnology, Amrita Vishwa Vidyapeetham, AmritapuriKerala, Kollam, 690525, India; Abhinand K., School of Biotechnology, Amrita Vishwa Vidyapeetham, AmritapuriKerala, Kollam, 690525, India; Menon A.M., School of Biotechnology, Amrita Vishwa Vidyapeetham, AmritapuriKerala, Kollam, 690525, India; Nair B.G., School of Biotechnology, Amrita Vishwa Vidyapeetham, AmritapuriKerala, Kollam, 690525, India; Kumar G.B., School of Biotechnology, Amrita Vishwa Vidyapeetham, AmritapuriKerala, Kollam, 690525, India; Arun K.B., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Edison L.K., Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, 32610, FL, United States; Madhavan A., School of Biotechnology, Amrita Vishwa Vidyapeetham, AmritapuriKerala, Kollam, 690525, India
- Rights
- All Open Access; Gold Open Access
- Relation
- ISSN: 16616596; PubMed ID: 39519352
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Thomas S.S.; Abhinand K.; Menon A.M.; Nair B.G.; Kumar G.B.; Arun K.B.; Edison L.K.; Madhavan A., “Epigenetic Mechanisms Induced by Mycobacterium tuberculosis to Promote Its Survival in the Host,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/21265.