Advancements in thiol-yne click chemistry: Recent trends and applications in polymer synthesis and functionalization
- Title
- Advancements in thiol-yne click chemistry: Recent trends and applications in polymer synthesis and functionalization
- Creator
- Sradha S A.; Sariga; George L.; Varghese A.
- Description
- The 2022 Nobel Prize in chemistry brought the world's attention to click chemistry, a field as fascinating as its name, characterized by attractive features like high yield, stereospecificity, and broad scope. Since its inception, click chemistry has been synonymous with copper-catalyzed azide-alkyne reactions, owing to their remarkable advantages. However, as the field advanced, there has been a proactive search to develop metal-free alternatives for more biocompatible applications. This led to the extensive adoption of thiol-ene click reactions in the past decade. Yet, due to the growing requirement for polymers with complex architecture and functionality, in recent years, thiol-yne click reactions have come to the forefront with additional advantages over its ene counterparts, allowing the addition of two thiols to an alkyne. This review provides a concise overview of some of the significant developments in polymer synthesis and functionalization utilizing thiol-yne click chemistry. The focus is primarily on radical-mediated thiol-yne reactions, considering the substantial body of work in this area. Moreover, the review provides adequate discussion on other mechanistic pathways like nucleophilic and metal-catalyzed thiol-yne reactions that have gained traction recently. 2024 Elsevier Ltd
- Source
- Materials Today Chemistry, Vol-38
- Date
- 2024-01-01
- Publisher
- Elsevier Ltd
- Subject
- Hyperbranched polymers; Network polymers; Polymer synthesis; Radical-mediated; Surface functionalization; Thiol-yne click chemistry
- Coverage
- Sradha S A., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Sariga, Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; George L., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Varghese A., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India
- Rights
- Restricted Access
- Relation
- ISSN: 24685194
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Sradha S A.; Sariga; George L.; Varghese A., “Advancements in thiol-yne click chemistry: Recent trends and applications in polymer synthesis and functionalization,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/21307.