Recent advances in polyethylene glycol as a dual-functional agent in heterocycle synthesis: Solvent and catalyst
- Title
- Recent advances in polyethylene glycol as a dual-functional agent in heterocycle synthesis: Solvent and catalyst
- Creator
- Servesh A.; Lokesh Kumar S.; Govindaraju S.; Tabassum S.; Raj Prasad J.; Kumar N.; Ramaraj S.G.
- Description
- Reactant solubility, which dictates achievable concentrations, and the stability of reaction intermediates (excited states), solvents modulate the potential energy landscape and influence reaction rates. Consequently, solvent selection is pivotal in optimizing process productivity, economic feasibility, and environmental footprint. At present, organic synthesis pivots around the idea of sustainability. In particular, PEG-400, a popular solvent and phase transfer catalyst, is considered greener as it can be reused several times without significant loss in its catalytic activity, which checks the box regarding sustainability. This review highlights the emerging potential of Polyethylene Glycol 400 (PEG-400) as a dual-threat agent in sustainable organic synthesis. We explore its efficacy as a catalyst, promoting various reactions under mild conditions and often eliminating the need for traditional metal catalysts. Additionally, PEG-400's role as a green solvent is addressed, emphasizing its biodegradability, low toxicity, and ability to facilitate reactions without hazardous Volatile Organic Compounds (VOCs). The review examines recent research on PEG-400 mediated reactions, showcasing its effectiveness in diverse transformations, thus exploring the potential of PEG 400 as a facilitator for heterocycle synthesis in both multicomponent reactions and stepwise approaches. It identifies exciting research directions that promise to expand the boundaries of polymer-based solvents in heterocyclic chemistry. 2024 The Author(s). Polymers for Advanced Technologies published by John Wiley & Sons Ltd.
- Source
- Polymers for Advanced Technologies, Vol-35, No. 6
- Date
- 2024-01-01
- Publisher
- John Wiley and Sons Ltd
- Subject
- catalysis; green solvent; polyethylene glycol-400; recyclability; review
- Coverage
- Servesh A., Department of Chemistry, Christ University, Karnataka, Bengaluru, India; Lokesh Kumar S., Department of Chemistry, Christ University, Karnataka, Bengaluru, India; Govindaraju S., Department of Sciences & Humanities, Christ University, Karnataka, Bengaluru, India; Tabassum S., Department of Chemistry, Surana College, Karnataka, Bengaluru, India; Raj Prasad J., Department of Civil Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Tamilnadu, Katankulathur, India; Kumar N., Department of Electronic & Communication Engineering, Graphics Era Deemed to be University, Uttarakhand, Dehradun, India; Ramaraj S.G., Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan, Department of Materials Physics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMTS), Tamilnadu, Chennai, India
- Rights
- All Open Access; Hybrid Gold Open Access
- Relation
- ISSN: 10427147
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Servesh A.; Lokesh Kumar S.; Govindaraju S.; Tabassum S.; Raj Prasad J.; Kumar N.; Ramaraj S.G., “Recent advances in polyethylene glycol as a dual-functional agent in heterocycle synthesis: Solvent and catalyst,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/21306.