Anticancer activity and other biomedical properties of ?-sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches
- Title
- Anticancer activity and other biomedical properties of ?-sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches
- Creator
- Nandi S.; Nag A.; Khatua S.; Sen S.; Chakraborty N.; Naskar A.; Acharya K.; Calina D.; Sharifi-Rad J.
- Description
- Sterols, including ?-sitosterol, are essential components of cellular membranes in both plant and animal cells. Despite being a major phytosterol in various plant materials, comprehensive scientific knowledge regarding the properties of ?-sitosterol and its potential applications is essential for scholarly pursuits and utilization purposes. ?-sitosterol shares similar chemical characteristics with cholesterol and exhibits several pharmacological activities without major toxicity. This study aims to bridge the gap between phytochemistry and current pharmacological evidence of ?-sitosterol, focusing on its anticancer activity and other biomedical properties. The goal is to provide a comprehensive understanding of ?-sitosterol's potential for future translational approaches. A thorough examination of the literature was conducted to gather relevant information on the biological properties of ?-sitosterol, particularly its anticancer therapeutic potential. Various databases were searched, including PubMed/MedLine, Scopus, Google Scholar, and Web of Science using appropriate keywords. Studies investigating the effects of ?-sitosterol on different types of cancer were analyzed, focusing on mechanisms of action, pharmacological screening, and chemosensitizing properties. Modern pharmacological screening studies have revealed the potential anticancer therapeutic properties of ?-sitosterol against various types of cancer, including leukemia, lung, stomach, breast, colon, ovarian, and prostate cancer. ?-sitosterol has demonstrated chemosensitizing effects on cancer cells, interfering with multiple cell signaling pathways involved in proliferation, cell cycle arrest, apoptosis, survival, metastasis invasion, angiogenesis, and inflammation. Structural derivatives of ?-sitosterol have also shown anti-cancer effects. However, research in the field of drug delivery and the detailed mode of action of ?-sitosterol-mediated anticancer activities remains limited. ?-sitosterol, as a non-toxic compound with significant pharmacological potential, exhibits promising anticancer effects against various cancer types. Despite being relatively less potent than conventional cancer chemotherapeutics, ?-sitosterol holds potential as a safe and effective nutraceutical against cancer. Further comprehensive studies are recommended to explore the biological properties of ?-sitosterol, including its mode of action, and develop novel formulations for its potential use in cancer treatment. This review provides a foundation for future investigations and highlights the need for further research on ?-sitosterol as a potent superfood in combating cancer. 2023 John Wiley & Sons Ltd.
- Source
- Phytotherapy Research, Vol-38, No. 2, pp. 592-619.
- Date
- 2024-01-01
- Publisher
- John Wiley and Sons Ltd
- Subject
- anticancer activity; biomedical properties; pharmacology; phytochemistry; translational research; ?-sitosterol
- Coverage
- Nandi S., Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India; Nag A., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Khatua S., Department of Botany, Faculty of Science, University of Allahabad, Prayagraj, India; Sen S., Department of Botany, Fakir Chand College, Kolkata, India; Chakraborty N., Department of Botany, Scottish Church College, Kolkata, India; Naskar A., Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India; Acharya K., Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India; Calina D., Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania; Sharifi-Rad J., Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
- Rights
- Restricted Access
- Relation
- ISSN: 0951418X; PubMed ID: 37929761; CODEN: PHYRE
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Nandi S.; Nag A.; Khatua S.; Sen S.; Chakraborty N.; Naskar A.; Acharya K.; Calina D.; Sharifi-Rad J., “Anticancer activity and other biomedical properties of ?-sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/21322.