Understanding the Role of Antimicrobial Peptides in Neutrophil Extracellular Traps Promoting Autoimmune Disorders
- Title
- Understanding the Role of Antimicrobial Peptides in Neutrophil Extracellular Traps Promoting Autoimmune Disorders
- Creator
- Biswas S.; Sarojini S.; Jayaram S.; Philip I.; Umesh M.; Mascarenhas R.; Pappuswamy M.; Balasubramanian B.; Arokiyaraj S.
- Description
- AMPs are small oligopeptides acting as integral elements of the innate immune system and are of tremendous potential in the medical field owing to their antimicrobial and immunomodulatory activities. They offer a multitude of immunomodulatory properties such as immune cell differentiation, inflammatory responses, cytokine production, and chemoattraction. Aberrancy in neutrophil or epithelial cell-producing AMPs leads to inflammation culminating in various autoimmune responses. In this review, we have tried to explore the role of prominent mammalian AMPsdefensins and cathelicidins, as immune regulators with special emphasis on their role in neutrophil extracellular traps which promotes autoimmune disorders. When complexed with self-DNA or self-RNA, AMPs act as autoantigens which activate plasmacytoid dendritic cells and myeloid dendritic cells leading to the production of interferons and cytokines. These trigger a series of self-directed inflammatory reactions, leading to the emergence of diverse autoimmune disorders. Since AMPs show both anti- and pro-inflammatory abilities in different ADs, there is a dire need for a complete understanding of their role before developing AMP-based therapy for autoimmune disorders. 2023 by the authors.
- Source
- Life, Vol-13, No. 6
- Date
- 2023-01-01
- Publisher
- MDPI
- Subject
- antimicrobial peptides; autoimmune disorders; cathelicidins; cytokines; defensins; neutrophil
- Coverage
- Biswas S., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Sarojini S., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Jayaram S., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Philip I., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Umesh M., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Mascarenhas R., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Pappuswamy M., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Arokiyaraj S., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea
- Rights
- All Open Access; Gold Open Access; Green Open Access
- Relation
- ISSN: 20751729
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Biswas S.; Sarojini S.; Jayaram S.; Philip I.; Umesh M.; Mascarenhas R.; Pappuswamy M.; Balasubramanian B.; Arokiyaraj S., “Understanding the Role of Antimicrobial Peptides in Neutrophil Extracellular Traps Promoting Autoimmune Disorders,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/21423.