Cytokine see-saw across pregnancy, its related complexities and consequences
- Title
- Cytokine see-saw across pregnancy, its related complexities and consequences
- Creator
- Meyyazhagan A.; Kuchi Bhotla H.; Pappuswamy M.; Tsibizova V.; Al Qasem M.; Di Renzo G.C.
- Description
- During pregnancy, a woman's immune system adapts to the changing hormonal concentrations, causing immunologic transition. These immunologic changes are required for a full-term pregnancy, preserving the fetus' innate and adaptive immunity. Preterm labor, miscarriage, gestational diabetes mellitus, and pre-eclampsia are all caused by abnormal cytokine expression during pregnancy and childbirth. A disruption in the cytokine balance can lead to autoimmune diseases or microbiologic infections, or to autoimmune illness remission during pregnancy with postpartum recurrence. The cytokine treatments are essential and damaging to the developing fetus. The current review summarizes the known research on cytokine changes during pregnancy and their possible consequences for pregnant women. Studies suggest that customizing medication for each woman and her progesterone levels should be based on the cytokine profile of each pregnant woman. Immune cells and chemicals play an important function in development of the placenta and embryo. During pregnancy, T cells divide and move, and a careful balance between proinflammatory and anti-inflammatory cytokines is necessary. The present review focuses on the mother's endurance in generating fetal cells and the immunologic mechanism involved. 2022 International Federation of Gynecology and Obstetrics.
- Source
- International Journal of Gynecology and Obstetrics, Vol-160, No. 2, pp. 516-525.
- Date
- 2023-01-01
- Publisher
- John Wiley and Sons Ltd
- Subject
- anti-inflammatory; cytokine; fetus; immune cells; pregnancy; pro-inflammatory
- Coverage
- Meyyazhagan A., Center for Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy, PREIS International and European School of Perinatal, Neonatal and Reproductive Medicine, Florence, Italy; Kuchi Bhotla H., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bengaluru, India; Pappuswamy M., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bengaluru, India; Tsibizova V., PREIS International and European School of Perinatal, Neonatal and Reproductive Medicine, Florence, Italy, Institute of Perinatology and Pediatrics, Almazov National Medical Research Center, Saint-Petersburg, Russian Federation; Al Qasem M., PREIS International and European School of Perinatal, Neonatal and Reproductive Medicine, Florence, Italy, Department of Obstetrics and Gynecology, Faculty of Medicine, Mutah University, Al-Karak, Jordan; Di Renzo G.C., Center for Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy, PREIS International and European School of Perinatal, Neonatal and Reproductive Medicine, Florence, Italy, Department of Obstetrics and Gynecology, I.M. Sechenov First State University of Moscow, Moscow, Russian Federation
- Rights
- Restricted Access
- Relation
- ISSN: 207292; PubMed ID: 35810391; CODEN: IJGOA
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Meyyazhagan A.; Kuchi Bhotla H.; Pappuswamy M.; Tsibizova V.; Al Qasem M.; Di Renzo G.C., “Cytokine see-saw across pregnancy, its related complexities and consequences,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/21444.