Design and genome engineering of microbial cell factories for efficient conversion of lignocellulose to fuel
- Title
- Design and genome engineering of microbial cell factories for efficient conversion of lignocellulose to fuel
- Creator
- Madhavan A.; Arun K.B.; Sindhu R.; Nair B.G.; Pandey A.; Awasthi M.K.; Szakacs G.; Binod P.
- Description
- The gradually increasing need for fossil fuels demands renewable biofuel substitutes. This has fascinated an increasing investigation to design innovative energy fuels that have comparable Physico-chemical and combustion characteristics with fossil-derived fuels. The efficient microbes for bioenergy synthesis desire the proficiency to consume a large quantity of carbon substrate, transfer various carbohydrates through efficient metabolic pathways, capability to withstand inhibitory components and other degradation compounds, and improve metabolic fluxes to synthesize target compounds. Metabolically engineered microbes could be an efficient methodology for synthesizing biofuel from cellulosic biomass by cautiously manipulating enzymes and metabolic pathways. This review offers a comprehensive perspective on the trends and advances in metabolic and genetic engineering technologies for advanced biofuel synthesis by applying various heterologous hosts. Probable technologies include enzyme engineering, heterologous expression of multiple genes, CRISPR-Cas technologies for genome editing, and cell surface display. 2022 Elsevier Ltd
- Source
- Bioresource Technology, Vol-370
- Date
- 2023-01-01
- Publisher
- Elsevier Ltd
- Subject
- Bacteria; Biofuel; Ethanol; Filamentous fungi; Metabolic engineering; Synthetic biology
- Coverage
- Madhavan A., School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kerala, Kollam, 690525, India; Arun K.B., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bengaluru, 560029, India; Sindhu R., Department of Food Technology, TKM Institute of Technology, Kollam, 689 122, India; Nair B.G., School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Kerala, Kollam, 690525, India; Pandey A., Center for Innovation and Translational Research, CSIR-Indian Institute of Toxicology Research, Lucknow, 226 001, India, Sustainability Cluster, School of Engineering, University of Petroleum and Energy Studies, Uttarkhand, Dehradun, 248007, India, Centre for Energy and Environmental Sustainability, Uttar Pradesh, Lucknow 226 029, India; Awasthi M.K., College of Natural Resources and Environment, Northwest A & F University, Shaanxi, Yangling, 712 100, China; Szakacs G., Budapest University of Technology and Economics, Department of Applied Biotechnology and Food Science, Szent Gellert ter 4, Budapest, 1111, Hungary; Binod P., Microbial Processes and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Trivandrum, 695 019, India
- Rights
- Restricted Access
- Relation
- ISSN: 9608524; PubMed ID: 36586428; CODEN: BIRTE
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Madhavan A.; Arun K.B.; Sindhu R.; Nair B.G.; Pandey A.; Awasthi M.K.; Szakacs G.; Binod P., “Design and genome engineering of microbial cell factories for efficient conversion of lignocellulose to fuel,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/21445.