The crux of bioactive metabolites in endophytic and thermophilic fungi and their proximal prospects in biotechnological and industrial domains
- Title
- The crux of bioactive metabolites in endophytic and thermophilic fungi and their proximal prospects in biotechnological and industrial domains
- Creator
- Pushparaj K.; Meyyazhagan A.; Bhotla H.K.; Arumugam V.A.; Pappuswamy M.; Vadivalagan C.; Hakeem K.R.; Balasubramanian B.; Liu W.; Mousavi Khaneghah A.
- Description
- Fungi are ubiquitous in distribution and are found in grasses to hot springs. Their mode of nutrition provides sustenance for living and propagation. Ironically, varied fungal species have developed customized strategies for protection and survival by producing diverse secondary metabolites. The review aimed to project the contrasting potential features of the endophytic and thermophilic fungi groups. The metabolites and the enzymes of endophytic and thermophilic fungi served as the backbone to thrive and adapt within-host and in extreme conditions like higher pH, heat, and salinity, respectively. Identification, knowledge of their biochemistry and pathway, exploration, production, and utilization of these bioactive molecules in various commercial, industrial, and pharmaceutical domains were briefly discussed. The uniqueness of endophytes includes stress management and improved biomass production of the host, green fuel production, omnipresence, selected triple-symbiosis with the virus, synthesis of polyketides, and other active metabolites are widely used in biomedical applications and agriculture management. This review attempted to limelight the specific applications of thermophilic fungal metabolites and the roles of thermo-stable enzymes in bioprospecting. Moreover, probing the metabolites of thermophiles rendered novel antibiotic compounds, which were proven effective against multi-drug resistant bacteria and harboured the potential to curtail infectious diseases. 2022 Elsevier Ltd
- Source
- Toxicon, Vol-223
- Date
- 2023-01-01
- Publisher
- Elsevier Ltd
- Subject
- Biomedical; Bioprospecting; Endophytic fungi; Enzymes; Secondary metabolites; Thermophilic fungi
- Coverage
- Pushparaj K., Department of Zoology, School of Biosciences, Avinashilingam Institute for Home Science and Higher Education for Women, Tamil Nadu, Coimbatore, 641 043, India; Meyyazhagan A., Department of Life Science, CHRIST (Deemed to Be University), Karnataka, Bengaluru, 560076, India; Bhotla H.K., Department of Life Science, CHRIST (Deemed to Be University), Karnataka, Bengaluru, 560076, India; Arumugam V.A., Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, 641 046, India; Pappuswamy M., Department of Life Science, CHRIST (Deemed to Be University), Karnataka, Bengaluru, 560076, India; Vadivalagan C., Department of Cosmeceutics, China Medical University, Taichung City, 406040, Taiwan; Hakeem K.R., Department of Biological Sciences, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Liu W., Department of Animal Science, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang, 524088, China; Mousavi Khaneghah A., Department of Fruit and Vegetable Product Technology, Prof. Wac?awD?browski Institute of Agricultural and Food Biotechnology State Research Institute, 36 Rakowiecka St., Warsaw, 02-532, Poland, Department of Technology of Chemistry, Azerbaijan State Oil and Industry University, Baku, Azerbaijan
- Rights
- Restricted Access
- Relation
- ISSN: 410101; PubMed ID: 36563862; CODEN: TOXIA
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Pushparaj K.; Meyyazhagan A.; Bhotla H.K.; Arumugam V.A.; Pappuswamy M.; Vadivalagan C.; Hakeem K.R.; Balasubramanian B.; Liu W.; Mousavi Khaneghah A., “The crux of bioactive metabolites in endophytic and thermophilic fungi and their proximal prospects in biotechnological and industrial domains,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/21448.