Green-synthesized nanoparticles and their therapeutic applications: A review
- Title
- Green-synthesized nanoparticles and their therapeutic applications: A review
- Creator
- Mayegowda S.B.; Sarma G.; Gadilingappa M.N.; Alghamdi S.; Aslam A.; Refaat B.; Almehmadi M.; Allahyani M.; Alsaiari A.A.; Aljuaid A.; Al-Moraya I.S.
- Description
- Antibiotic-resistant microorganisms are a rising issue when it comes to human health. Microbial pathogens that cause harmful infections are quickly becoming resistant to the antimicrobial action of traditional antibiotics. Nanotechnology, an innovative sector being an indispensable part of healthcare and research, has in-depth and extensive applications. Nano-compounds have been promising antimicrobial agents, anti-cancerous mediators, vehicles for drug delivery, formulations for functional foods, identification of pathogens, food and drug packaging industry, and many more. However, the chemical synthesis of nanoparticles (NPs) has certain drawbacks such as causing toxicity and other adverse effects. For more than a decade, the use of NPs that are conjugated or green-synthesized has gained popularity due to the two-fold action of metallic NPs mixed with biological sources. In contrast, NPs synthesized using plant or microbial extracts, conjugated with biologically active components, appear to be a safe alternative approach as they are environmentally friendly and cost-effective. Such environmentally safe techniques are referred to as "green nanotechnology"or "clean technology"and are feasible alternatives to chemical methods. Furthermore, NPs conjugated with natural biomolecules have improved bioavailability and have minimal side effects, as they are smaller in size and have higher permeability in addition to being reducing and stabilizing agents possessing excellent antioxidant activity. NPs serve as potential antimicrobial agents due to their affinity towards sulphur-rich amino acids, adhere to microbial cell walls by means of electrostatic attraction, and disrupt the cytoplasmic membrane along with the nucleic acid of microbes. They possess anticancer activity owing to oxidative stress, damage to cellular DNA, and lipid peroxidation. The green-synthesized NPs are thus a promising and safe alternative for healthcare therapeutic applications. 2023 the author(s), published by De Gruyter.
- Source
- Green Processing and Synthesis, Vol-12, No. 1
- Date
- 2023-01-01
- Publisher
- De Gruyter Open Ltd
- Subject
- alternative approach; anticancer; antioxidant; drug delivery; eco-friendly
- Coverage
- Mayegowda S.B., Department of Psychology, CHRIST-Deemed to Be University, Bangalore Kengeri Campus, Kanmanike, Kumbalgodu, Mysore Road, Karnataka, Bangalore, 560074, India; Sarma G., Department of Microbiology, School of Basic and Applied Sciences (SBAS), Dayananda Sagar University, Karnataka, Bengaluru, 560100, India; Gadilingappa M.N., Department of Microbiology, School of Basic and Applied Sciences (SBAS), Dayananda Sagar University, Karnataka, Bengaluru, 560100, India; Alghamdi S., Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia; Aslam A., Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia; Refaat B., Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia; Almehmadi M., Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P. O. Box 11099, Taif, 21944, Saudi Arabia; Allahyani M., Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P. O. Box 11099, Taif, 21944, Saudi Arabia; Alsaiari A.A., Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P. O. Box 11099, Taif, 21944, Saudi Arabia; Aljuaid A., Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P. O. Box 11099, Taif, 21944, Saudi Arabia; Al-Moraya I.S., Forensic Medicine Center, Ministry of Health, Abha, Saudi Arabia
- Rights
- All Open Access; Gold Open Access
- Relation
- ISSN: 21919542
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Mayegowda S.B.; Sarma G.; Gadilingappa M.N.; Alghamdi S.; Aslam A.; Refaat B.; Almehmadi M.; Allahyani M.; Alsaiari A.A.; Aljuaid A.; Al-Moraya I.S., “Green-synthesized nanoparticles and their therapeutic applications: A review,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/21469.