ItemReview

Review on the Biogenesis of Platelets in Lungs and Its Alterations in SARS-CoV-2 Infection Patients

Title
Review on the Biogenesis of Platelets in Lungs and Its Alterations in SARS-CoV-2 Infection Patients
Creator
Nandhini B.; Sureshraj Y.; Kaviya M.; Sangeetha T.; Bharathi K.; Balamuralikrishnan B.; Manikantan P.; Arun M.; Haripriya K.B.; Karthika P.; Kalidass S.; Anand A.V.
Description
Thrombocytes (platelets) are the type of blood cells that are involved in hemostasis, thrombosis, etc. For the conversion of megakaryocytes into thrombocytes, the thrombopoietin (TPO) protein is essential which is encoded by the TPO gene. TPO gene is present in the long arm of chromosome number 3 (3q26). This TPO protein interacts with the c-Mpl receptor, which is present on the outer surface of megakaryocytes. As a result, megakaryocyte breaks into the production of functional thrombocytes. Some of the evidence shows that the megakaryocytes, the precursor of thrombocytes, are seen in the lungs interstitium. This review focuses on the involvement of the lungs in the production of thrombocytes and their mechanism. A lot of findings show that viral diseases, which affect the lungs, cause thrombocytopenia in human beings. One of the notable viral diseases is COVID-19 or severe acute respiratory syndrome caused by SARS-associated coronavirus 2 (SARS-CoV-2). SARS-CoV-2 caused a worldwide alarm in 2019 and a lot of people suffered because of this disease. It mainly targets the lung cells for its replication. To enter the cells, these virus targets the angiotensin-converting enzyme-2 (ACE-2) receptors that are abundantly seen on the surface of the lung cells. Recent reports of COVID-19-affected patients reveal the important fact that these peoples develop thrombocytopenia as a post-COVID condition. This review elaborates on the biogenesis of platelets in the lungs and the alterations of thrombocytes during the COVID-19 infection. 2023, SAGE Publications Ltd. All rights reserved.
Source
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, Vol-2023
Date
2023-01-01
Publisher
SAGE Publications Ltd
Coverage
Nandhini B., Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India; Sureshraj Y., Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India; Kaviya M., Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India; Sangeetha T., Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India; Bharathi K., Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India; Balamuralikrishnan B., Department of Food Science and Biotechnology, Sejong University, Seoul, South Korea; Manikantan P., Department of Life Sciences Christ Deemed to be University, Bengaluru, India; Arun M., Department of Life Sciences Christ Deemed to be University, Bengaluru, India; Haripriya K.B., Department of Life Sciences Christ Deemed to be University, Bengaluru, India; Karthika P., Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Tamil Nadu, Coimbatore, India; Kalidass S., Department of Animal Science, Manonmaniam Sundaranar University, Tamil Nadu, Tirunelveli, India; Anand A.V., Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India
Rights
All Open Access; Green Open Access; Hybrid Gold Open Access
Relation
ISSN: 14703203; PubMed ID: 36891250; CODEN: JRAAA
Format
Online
Language
English
Type
Review

Collection

Reviews

Citation

Nandhini B.; Sureshraj Y.; Kaviya M.; Sangeetha T.; Bharathi K.; Balamuralikrishnan B.; Manikantan P.; Arun M.; Haripriya K.B.; Karthika P.; Kalidass S.; Anand A.V., “Review on the Biogenesis of Platelets in Lungs and Its Alterations in SARS-CoV-2 Infection Patients,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/21470.

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