A Short Review on Recent Applications of Chitosan Biopolymer in Gene and Drug Delivery

Title

A Short Review on Recent Applications of Chitosan Biopolymer in Gene and Drug Delivery

Creator

Suresh S.; Umesh M.; Sarojini S.

Description

The battle of the human race with genetic disorders was prevailing from the time immemorial. Revolutions and modernizations in science and technology have clearly improved our understanding regarding the molecular basis of genetic disorders thereby aiding in designing new therapeutic interventions in their treatment and prevention. With the advent and development of gene therapy in the last few decades, promising windows were opened for treatment and prevention of genetic disorders and cancer. Despite of its remarkable significance in medicine, the common practice of using viral vectors as gene delivery agents has created controversies and concerns among the scientific community. This made the research focus on biobased polymers as alternative non-viral vector systems for gene and drug delivery for treating genetic disorders and cancer. Chitosan is a cationic polymer that can be easily tailored to serve as gene and drug delivery due to their biocompatibility and biodegradability. Their structural integrity and stability have made them widely used for various applications in the biomedical field. Chitosan and its derivatives have gained more attention as vectors for gene delivery and cancer therapy in the past decade. The amenability of structural modification, non-toxicity and high biodegradability of chitosan derivatives can make them prospective carriers for controlled drug delivery in future. 2022 Chemical Publishing Co.. All rights reserved.

Source

Asian Journal of Chemistry, Vol-34, No. 4, pp. 787-792.

Date

2022-01-01

Publisher

Asian Publication Corporation

Subject

Biopolymers; Chitosan; Drug delivery; Gene delivery; Gene therapy; Vectors

Coverage

Suresh S., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, 560029, India; Umesh M., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, 560029, India; Sarojini S., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, 560029, India

Rights

All Open Access; Gold Open Access

Relation

ISSN: 9707077; CODEN: AJCHE

Format

Online

Language

English

Type

Review

Identifier

https://doi.org/10.14233/ajchem.2022.23548

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