ItemArticle

Evaluation of the Neuroprotective Efficacies and Related Mechanisms of Cirsimaritin in MPTP-Induced Parkinson in Mice with Following the Molecular Docking Studies

Title
Evaluation of the Neuroprotective Efficacies and Related Mechanisms of Cirsimaritin in MPTP-Induced Parkinson in Mice with Following the Molecular Docking Studies
Creator
Wei, Yan; Li, Qi; Hirad, Abdurahman Hajinur; Alarfaj, Abdullah A.; Thangavelu, Indumathi; Arulselvan, Palanisamy
Description
Parkinsons disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuronal loss and oxidative stressinduced apoptosis. The present study evaluated the neuroprotective potential of cirsimaritin against MPTP-induced PD in mice and explored its possible mechanism through combined in silico and in vivo approaches. Molecular docking using AutoDock Vina revealed that cirsimaritin exhibits strong binding affinities with key antioxidant enzymes (CAT, GPx, and SOD) and apoptosis-related proteins (Bcl-2, Bax, caspase-3, ?8, and ? 9), suggesting possible modulation of oxidative and apoptotic signaling pathways. In vivo, PD was induced by MPTP (30mg/kg, i.p., for 7days), followed by oral administration of cirsimaritin (25 and 50mg/kg). Behavioral assessmentsincluding the open field, narrow beam walking, and wire hanging testsdemonstrated significant improvement in locomotor and neuromuscular performance in cirsimaritin-treated mice. Biochemical analyses revealed that cirsimaritin restored dopamine and its metabolites, decreased lipid peroxidation (TBARS), and enhanced antioxidant enzyme activities (CAT, SOD, and GPx). Additionally, cirsimaritin attenuated apoptosis by upregulating Bcl-2 and downregulating Bax and caspase-3 expression. Histopathological examination confirmed reduced neurodegeneration in the brain hippocampus of treated mice. These findings indicate that cirsimaritin exerts potent neuroprotective effects in MPTP-induced PD mice, likely through its antioxidant and anti-apoptotic actions, supporting its potential as a therapeutic candidate for Parkinsons disease. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026.
Source
Journal of Pharmaceutical Innovation;Volume;21;Issue;3;Article No.;244;
Date
01-01-2026
Publisher
Springer
Subject
Apoptosis; Cirsimaritin; Dopamine; Neurodegeneration; Oxidative stress
Coverage
Wei Y., Department of Encephalopathy, Xian Hospital of Traditional Chinese Medicine, Xian, China; Li Q., Department of Encephalopathy, Xian Hospital of Traditional Chinese Medicine, Xian, China; Hirad A.H., Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box. 2455, 11451, Riyadh, Saudi Arabia; Alarfaj A.A., Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box. 2455, 11451, Riyadh, Saudi Arabia; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, India; Arulselvan P., Department of Biochemistry, Karpagam Academy of Higher Education (Deemed to be University), Tamilnadu, Coimbatore, 641021, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 18725120;
Format
online
Language
English
Type
Article

Citation

Wei, Yan; Li, Qi; Hirad, Abdurahman Hajinur; Alarfaj, Abdullah A.; Thangavelu, Indumathi; Arulselvan, Palanisamy, “Evaluation of the Neuroprotective Efficacies and Related Mechanisms of Cirsimaritin in MPTP-Induced Parkinson in Mice with Following the Molecular Docking Studies,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22008.

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