ItemArticle

Innovative fish peptide-loaded chitosomes: Advancing bioactive delivery through comprehensive in vitro and in vivo assessments

Title
Innovative fish peptide-loaded chitosomes: Advancing bioactive delivery through comprehensive in vitro and in vivo assessments
Creator
Joy, Jean Mary; P?, Amruth; Paul, Preethy Treesa; M?, Rosemol Jacob; Dara, Pavan Kumar; Mathew, Suseela
Description
Considerable advancements have been achieved in controlled delivery systems, yet ensuring optimal stability, bioavailability, and precise targeting of bioactive compounds continues to present challenges. Addressing this gap, the present study explores chitosomeslipid vesicles stabilized by chitosanas a promising approach to enhance the delivery efficiency of bioactive molecules. This study investigate fish peptide-loaded chitosomes, leveraging chitosan's biocompatibility, biodegradability, and encapsulation capabilities. A comprehensive evaluation was conducted under both in vitro and in vivo conditions to assess their potential applications. In vitro studies using L929 cell lines demonstrated high biocompatibility, efficient cellular uptake, and sustained cell viability, with a dose-dependent cytotoxicity profile, leading to early and late apoptosis. The tolerance, favourable metabolic stability, and biomarker responses were validated by in vivo evaluations in Albino Wistar rats, demonstrating systemic efficacy and safety. Moreover, the peptide-chitosome formulation demonstrated a lipid-lowering impact, as evidenced by increases in high-density lipoprotein (HDL) and unsaturated fatty acids and decreases in triglycerides, saturated fatty acid content, and low-density lipoprotein (LDL). These findings highlight the potential of fish peptide-loaded chitosomes as an advanced bioactive delivery system, addressing existing limitations and expanding their applicability in nutraceutical and therapeutic formulations. 2025 The Author(s)
Source
Food Chemistry Advances;Volume;7;Issue;;Article No.;100947;
Date
01-01-2025
Publisher
Elsevier Ltd
Subject
Chitosome; Fish bioactive peptide; Nutraceuticals; Stability
Coverage
Joy J.M., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India, Faculty of Marine Sciences, Cochin University of Science and Technology, Kerala, Cochin, 682022, India, Department of Zoology, St. Teresa's College (Autonomous), Kerala, Ernakulam, 682011, India; P? A., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India, Faculty of Marine Sciences, Cochin University of Science and Technology, Kerala, Cochin, 682022, India, Department of Life Sciences, Christ University, Hosur Main Road, Bhavani Nagar, Karnataka, Banglore, 560029, India; Paul P.T., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India, Faculty of Marine Sciences, Cochin University of Science and Technology, Kerala, Cochin, 682022, India; M? R.J., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India, Faculty of Marine Sciences, Cochin University of Science and Technology, Kerala, Cochin, 682022, India; Dara P.K., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India, Department of Biotechnology, Faculty of Science and Humanities, SRMIST, Tamil Nadu, Kattankulathur, 603203, India; Mathew S., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India
Rights
All Open Access; Gold Open Access; Green Open Access
Relation
ISSN: 2772753X;
Format
online
Language
English
Type
Article

Citation

Joy, Jean Mary; P?, Amruth; Paul, Preethy Treesa; M?, Rosemol Jacob; Dara, Pavan Kumar; Mathew, Suseela, “Innovative fish peptide-loaded chitosomes: Advancing bioactive delivery through comprehensive in vitro and in vivo assessments,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22258.

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