ItemArticle

Chitosan stabilized platinum nanoparticles: In vitro and in vivo screening for analgesic and anti-inflammatory applications

Title
Chitosan stabilized platinum nanoparticles: In vitro and in vivo screening for analgesic and anti-inflammatory applications
Creator
Felicia Aswathy Waliaveettil; Anila, E.I.
Description
In this interdisciplinary research work, the chitosan stabilized platinum nanoparticles are synthesized through the wet chemical method, and the structural, surface morphological, and optical characterizations are done using X-ray crystallography, Raman spectroscopy, transmission electron microscopy, etc. The samples were tested in in vitro trials namely egg albumin denaturation assay and DPPH radical scavenging assays and showed significantly lower effective concentrations (EC50) such as 5.44 ?g/ml and 8.068 ?g/ml respectively. The in vitro experiments were followed by in vivo animal model for analgesic and anti-inflammatory behaviour at two doses of 25 mg/kg and 50 mg/kg utilizing the hot plate method and the carrageenan-induced paw edema model respectively. The in vivo hot plate model for analgesic effect demonstrated that the chitosan stabilized platinum nanoparticles perform exceptionally well and show >90 % analgesia (p < 0.01) by extending the reaction time in the hot plate methodindicating better analgesia. Carrageenan-induced paw edema model demonstrated the exceptional anti-inflammatory ability of chitosan-stabilized platinum nanoparticles. Despite being given at a comparatively lower dosage, chitosan stabilized platinum nanoparticles showed a considerable decrease in paw volume (4045 % edema inhibition) by the third hour of the anti-inflammatory experimentation (p < 0.01) outperforming the standard drug aspirin given at 100 mg/kg. 2025 Elsevier B.V.
Source
International Journal of Biological Macromolecules;Volume;307;Issue;;Article No.;142103;
Date
01-01-2025
Publisher
Elsevier B.V.
Subject
Analgesic property; Anti-inflammatory property; Chitosan; DPPH assay; In vivo animal studies; Platinum nanoparticle
Coverage
Felicia Aswathy Waliaveettil, Department of Physics and Electronics, CHRIST University, Karnataka, Bengaluru, 560029, India; Anila E.I., Department of Physics and Electronics, CHRIST University, Karnataka, Bengaluru, 560029, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 1418130; CODEN: IJBMD
Format
online
Language
English
Type
Article

Citation

Felicia Aswathy Waliaveettil; Anila, E.I., “Chitosan stabilized platinum nanoparticles: In vitro and in vivo screening for analgesic and anti-inflammatory applications,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22286.

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