ItemArticle

Wound healing efficacy of Couroupita Guianensis loaded carboxymethylcellulose film

Title
Wound healing efficacy of Couroupita Guianensis loaded carboxymethylcellulose film
Creator
Ayyanar, C. Balaji; Bal, Trishna; Das, Itishree Jogamaya; Thomas, Sabu; Kenned, Jack J.; Bhattacharyya, Joydeep
Description
Couroupita Guianensis extracts loaded carboxymethylcellulose film (CGELCF) was fabricated through a solution casting technique. Phytochemical screening confirmed the presence of alkaloids, proteins, flavonoids, saponins, carbohydrates, cardiac glycosides, and coumarins in CGE. The HPLC revealed that ellagic acid and gallic acid derivatives are abundant in CGE. FTIR spectrum confirmed the different functional group's presence in the film. The XRD, DSC, and TGA revealed the crystallinity, thermal stability, melting point (300 C), and degradation of the film. FESEM and EDX analysis revealed surface morphology and elemental compositions. The atomic wt% of C, O, Na, and P were found as follows 38.39, 49.34, 11.44, and 0.83. The zone of inhibition was found as 19 and 20 mm against Staphylococcus aureus and Escherichia coli respectively. The tensile strength and modulus of elasticity was found 7.35 MPa and 1.38 GPa respectively. In-vitro wound scratch revealed above 90 % of cell migrations for all the concentrations after 18 h. The in-vitro cytotoxicity revealed 90.83 % of cell viability and 9.17 % of toxicity. In-vivo studies revealed that wound closure and wound healing with the CGELCF mice was within 7 days and exhibited the rapid drug. The CGELCF may find usage as a bandage for wounds. 2025
Source
International Journal of Biological Macromolecules;Volume;320;Issue;;Article No.;146166;
Date
01-01-2025
Publisher
Elsevier B.V.
Subject
Mice model; Phytochemical; Wound healing
Coverage
Ayyanar C.B., Department of Mechanical Engineering, Advanced Manufacturing Technology Laboratory, Coimbatore Institute of Technology, Tamilnadu, Coimbatore, 641014, India; Bal T., Biomaterial & Biomedical Research Lab, Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, India; Das I.J., Biomaterial & Biomedical Research Lab, Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, India; Thomas S., International and Inter-University Centre for Nanoscience and Nanotechnology, School of Chemical Sciences, School of Polymer Science and Technology, Mahatma Gandhi University, Kottayam 686 560, Kerala, India, Department of Physics & Electronics, CHRIST University, Bangalore, India, Department of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg, 2028, South Africa; Kenned J.J., Department of Mechanical Engineering, National Institute of Technology Puducherry Karaikal, Puducherry, 609609, India; Bhattacharyya J., Biomaterial & Biomedical Research Lab, Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 1418130; CODEN: IJBMD
Format
online
Language
English
Type
Article

Citation

Ayyanar, C. Balaji; Bal, Trishna; Das, Itishree Jogamaya; Thomas, Sabu; Kenned, Jack J.; Bhattacharyya, Joydeep, “Wound healing efficacy of Couroupita Guianensis loaded carboxymethylcellulose film,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22288.

Output Formats