ItemArticle

Sodium alginate functionalized nickel ferrite nanocomposites: synthesis, physicochemical characterization, and evaluation of antibacterial, anticancer, and biocompatibility properties

Title
Sodium alginate functionalized nickel ferrite nanocomposites: synthesis, physicochemical characterization, and evaluation of antibacterial, anticancer, and biocompatibility properties
Creator
Pattnaik, Snigdha; Shashikala, A.R.; Sharma, Kamini; Khambhati, Vishakha Prafulchandra; Thangavelu, Indumathi; Arulselvan, Palanisamy; Tadepalli, Srinivas; Ben Hamida, Mohamed Bechir
Description
The rise of multidrug-resistant bacteria and the need for effective therapies against breast cancer highlight the demand for multifunctional nanomaterials with high biocompatibility. In this study, Nickel ferrite (NiFe?O?) and sodium alginate functionalized NiFe?O? nanocomposites (NiFe?O?-SA) were synthesized via a green co-precipitation method. X-ray diffraction confirmed a cubic spinel structure, and transmission electron microscopy revealed quasi-spherical nanoparticles with sizes of 1525nm and uniform alginate coating. UVVis analysis showed a reduction in band gap from 4.44eV to 3.13eV, while photoluminescence spectra indicated enhanced charge carrier separation. NiFe?O?-SA exhibited strong antibacterial activity against Gram-negative pathogens (Klebsiella pneumoniae, Escherichia coli, Shigella dysenteriae, Pseudomonas aeruginosa, and Proteus vulgaris), with membrane disruption confirmed by microscopy. Cytotoxicity studies on MCF-7 breast cancer cells demonstrated dose-dependent inhibition with an IC?? of 11.9?g/mL, and zebrafish embryo assays confirmed excellent biocompatibility for NiFe?O?-SA. These findings highlight NiFe?O?-SA nanocomposites as promising multifunctional nanomaterials for therapeutic and biomedical applications. 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Source
International Journal of Biological Macromolecules;Volume;359;Issue;;Article No.;151717;
Date
01-01-2026
Publisher
Elsevier B.V.
Subject
Antibacterial; Biocompatibility; Breast cancer; Nickel ferrite; Sodium alginate coated nickel ferrite; Zebra fish studies
Coverage
Pattnaik S., Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Odisha, Bhubaneswar, 751030, India; Shashikala A.R., Department of Chemistry, Presidency University, Karnataka, Bengaluru, 560064, India; Sharma K., Department of FBAS (Chemistry), Vivekananda Global University, Jaipur, 303012, India; Khambhati V.P., Department of Biomedical Engineering, Faculty of Engineering and Technology, Parul Institute of Technology, Parul University, Gujarat, Vadodara, 391760, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Arulselvan P., Department of Biochemistry, Karpagam Academy of Higher Education (Deemed to Be University), Tamilnadu, Coimbatore, 641 021, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Ben Hamida M.B., Deanship of Scientific Research, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 1418130; CODEN: IJBMD
Format
online
Language
English
Type
Article

Citation

Pattnaik, Snigdha; Shashikala, A.R.; Sharma, Kamini; Khambhati, Vishakha Prafulchandra; Thangavelu, Indumathi; Arulselvan, Palanisamy; Tadepalli, Srinivas; Ben Hamida, Mohamed Bechir, “Sodium alginate functionalized nickel ferrite nanocomposites: synthesis, physicochemical characterization, and evaluation of antibacterial, anticancer, and biocompatibility properties,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22289.

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