ItemArticle

Antibacterial performance of chitosan-modified magnesium fluoride nanoparticles: Synthesis and characterization

Title
Antibacterial performance of chitosan-modified magnesium fluoride nanoparticles: Synthesis and characterization
Creator
Dhadda, Surbhi; Rami, Esha; Sahoo, Ambika; Lakshmi, Chaitanya; Thangavelu, Indumathi; Arulselvan, Palanisamy; Tadepalli, Srinivas; Gadallah, Abdelrahman G.
Description
The rise of multidrug-resistant bacterial infections threatens human health by reducing the effectiveness of conventional antibiotics. This growing challenge highlights the urgent need for advanced nano-based antibacterial materials capable of overcoming resistance and providing broad-spectrum protection. In this study, magnesium fluoride (MgF2) NPs and Chitosan modified MgF2 (MgF2-Cs) were synthesized via a facile wet-chemical route and characterized to evaluate their structural, surface, and antibacterial properties. XRD confirmed the formation of tetragonal MgF2 with crystallite sizes of 29nm for MgF2 and 22nm for MgF?Cs, the reduction attributed to Cs-induced surface modification. FTIR, PL, and XPS analyses verified successful Cs incorporation through the presence of OH, NH?, CN, and OC=O functional groups and the preservation of the MgF2 lattice. DLS further supported increased hydrodynamic size upon polymer coating. PL analysis showed enhanced blue-green emission around 497nm in MgF2Cs, suggesting increased defect density and corresponding ROS-generation ability. Antibacterial activity against Gram-positive: S. aureus, S. pneumoniae and Gram-negative: K. pneumoniae, S. dysenteriae bacteria demonstrated significantly improved inhibition for MgF2Cs, with zone diameters of 1521mm, surpassing MgF2 (1216mm) and Cs (1115mm. The MIC and MBC values for MgF?-Cs against K. pneumoniae were determined to be 0.6mgmL?1 and 0.9mgmL?1, respectively. The enhanced antibacterial performance is attributed to synergistic effects of defect-mediated ROS production and Csbacteria electrostatic interactions. 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Source
International Journal of Biological Macromolecules;Volume;362;Issue;;Article No.;152126;
Date
01-01-2026
Publisher
Elsevier B.V.
Subject
Antibacterial activity; MgF2Cs; MIC and MBC
Coverage
Dhadda S., Department of FBAS (Chemistry), Vivekananda Global University, Jaipur, 303012, India; Rami E., Department of Biotechnology, Parul Institute of Applied Sciences (PIAS), Parul University, Gujarat, Vadodara, 391760, India; Sahoo A., Department of Biotechnology, Centre for Biotechnology, Siksha 'O' Anusandhan (Deemed to be University), Odisha, Bhubaneswar, 751030, India; Lakshmi C., Department of Chemistry, Presidency University, Karnataka, Bengaluru, 560119, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Arulselvan P., Department of Biochemistry, Karpagam Academy of Higher Education (Deemed to Be University), Tamilnadu, Coimbatore, 641 021, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Gadallah A.G., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 1418130; CODEN: IJBMD
Format
online
Language
English
Type
Article

Citation

Dhadda, Surbhi; Rami, Esha; Sahoo, Ambika; Lakshmi, Chaitanya; Thangavelu, Indumathi; Arulselvan, Palanisamy; Tadepalli, Srinivas; Gadallah, Abdelrahman G., “Antibacterial performance of chitosan-modified magnesium fluoride nanoparticles: Synthesis and characterization,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22290.

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