ItemArticle

Changes in the dynamic profile of beneficial metabolites during Panax ginseng somatic embryogenesis

Title
Changes in the dynamic profile of beneficial metabolites during Panax ginseng somatic embryogenesis
Creator
Han, Jong-Eun; Lee, Han-Sol; Son, Eun-Jeong; Murthy, Hosakatte Niranjana; Park, So-Young
Description
In this study, we characterized the dynamic changes in the metabolite profiles of Panax ginseng during somatic embryogenesis (SE) to explore their stage-specific functional potential. We quantified phenolic compounds and amino acids using high-performance liquid chromatography (HPLC), while bioactive metabolites were identified through LC-MS/MS analysis. During SE, the total phenolic content (TPC) and total flavonoid content (TFC) significantly increased at the globular-to-torpedo (GT) stage, exhibiting enhanced antioxidant activity. Anti-inflammatory activity and cytoprotective effects peaked during the young plantlet (Yp) stage, driven by the accumulation of terpenoid metabolites, such as ginsenosides Rd and sarcostin. Additionally, at the embryogenic stem cell (ESC) stage, stress-related amino acids such as GABA and proline, along with metabolites like venlafaxine, clebopride, and nemonapride, which possess neuromodulatory properties, were distinctively accumulated. These results reveal the stage-specific metabolites and associated biological characteristics of ginseng SE, demonstrating the potential of ginseng-derived metabolites for pharmacological and nutraceutical applications. 2025 The Authors
Source
Industrial Crops and Products;Volume;234;Issue;;Article No.;121535;
Date
01-01-2025
Publisher
Elsevier B.V.
Subject
Embryogenic stem cells; Free amino acids; Metabolomics; Panax ginseng; Somatic embryogenesis
Coverage
Han J.-E., Department of Horticultural Science, Division of Animal, Horticultural and Food Sciences, Chungbuk National University, Cheongju, 28644, South Korea; Lee H.-S., Department of Horticultural Science, Division of Animal, Horticultural and Food Sciences, Chungbuk National University, Cheongju, 28644, South Korea; Son E.-J., Korea Institute of Oriental Medicine, Yuseong-daero 1672, Yuseong-gu, Daejeon, 34054, South Korea; Murthy H.N., Department of Horticultural Science, Division of Animal, Horticultural and Food Sciences, Chungbuk National University, Cheongju, 28644, South Korea, Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Park S.-Y., Department of Horticultural Science, Division of Animal, Horticultural and Food Sciences, Chungbuk National University, Cheongju, 28644, South Korea
Rights
All Open Access; Gold Open Access
Relation
ISSN: 9266690; CODEN: ICRDE
Format
online
Language
English
Type
Article

Citation

Han, Jong-Eun; Lee, Han-Sol; Son, Eun-Jeong; Murthy, Hosakatte Niranjana; Park, So-Young, “Changes in the dynamic profile of beneficial metabolites during Panax ginseng somatic embryogenesis,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22308.

Output Formats