Biofunctional TiVO4chitosanL-histidine hybrid nanomaterials for enhanced antimicrobial and anticancer applications
- Title
- Biofunctional TiVO4chitosanL-histidine hybrid nanomaterials for enhanced antimicrobial and anticancer applications
- Creator
- Bhran, Ahmed A.; Boopathi, Thalakulam Shanmugam; Thangavelu, Indumathi; Ben Hamida, Mohamed Bechir
- Description
- The growing pervasiveness of multidrug-resistant (MDR) pathogens and the limitations of conventional chemotherapeutics demand the development of multifunctional nanomaterials with enhanced efficacy and biocompatibility. In this study, titanium vanadate (TiVO4) nanoparticles and TiVO4chitosanL-histidine (TiVO4CsLH) HNM's were successfully synthesized via a wet chemical solgel route followed by surface functionalization. Structural analysis confirmed the formation of phase-pure tetragonal TiVO4 with an average crystallite size of ?38 nm, which was significantly reduced to ?24 nm upon CsLH functionalization. UVVisible spectroscopy revealed band gap narrowing from 4.75 eV (TiVO4) to 4.15 eV (TiVO4CsLH), indicating modified electronic structure and improved light absorption. The TiVO4CsLH HNM's exhibited superior broad-spectrum antimicrobial activity, with inhibition zones ranging from 18 to 19 mm against Gram positive, Gram negative and fungal strain, outperforming TiVO4. In vitro anticancer evaluation against MCF-7 breast cancer cells demonstrated pronounced concentration- and time-dependent cytotoxicity, with IC50 values decreasing from 29.8 ?g mL?1 (24 h) to 20.6 ?g mL?1 (72 h), significantly lower than those of TiVO4. Biocompatibility studies using L929 fibroblast cells revealed high cell viability (>82%) even at 60 ?g mL?1, which confirms the selective anticancer activity of TiVO4-Cs-LH HNMs. The enhanced biological performance of the TiVO4CsLH HNM's arose from synergistic effects of reduced crystallite size, improved dispersion, defect-assisted charge separation, and biofunctional surface chemistry, making it a promising candidate for antimicrobial and anticancer applications. 2026 Elsevier B.V.
- Source
- Journal of Drug Delivery Science and Technology;Volume;121;Issue;;Article No.;108320;
- Date
- 01-01-2026
- Publisher
- Editions de Sante
- Subject
- Anticancer activity; Antimicrobial activity; Biocompatibility; Chitosan; L-histidine; TiVO4
- Coverage
- Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Boopathi T.S., Department of Chemistry, Amrita School of Physical Sciences Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India, Functional Materials Laboratory, Amrita School of Engineering Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Ben Hamida M.B., Deanship of Scientific Research, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia
- Rights
- Restricted Access; Hardcopy may be available in the library
- Relation
- ISSN: 17732247; CODEN: JDDSA
- Format
- online
- Language
- English
- Type
- Article
Collection
Citation
Bhran, Ahmed A.; Boopathi, Thalakulam Shanmugam; Thangavelu, Indumathi; Ben Hamida, Mohamed Bechir, “Biofunctional TiVO4chitosanL-histidine hybrid nanomaterials for enhanced antimicrobial and anticancer applications,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22332.