Biocompatible NiTiO3Dopamine nanocomposites for combating drug-resistant pathogens through membrane disruption and oxidative stress
- Title
- Biocompatible NiTiO3Dopamine nanocomposites for combating drug-resistant pathogens through membrane disruption and oxidative stress
- Creator
- Thangavelu, Indumathi; Tadepalli, Srinivas
- Description
- The rising threat of multidrug-resistant pathogens poses a challenge to public health. Highlighting the urgent need for novel antimicrobial agents, this study reports the synthesis of NiTiO3 nanoparticles and dopamine-functionalized NiTiO3 nanocomposites. Structural and elemental confirmation was obtained through XPS studies, which confirmed the presence of Ni2+ and Ti4+ in the nanocomposite, along with C 1s and O 1s peaks corresponding to dopamine coating. Photoluminescence spectra revealed that the NiTiO3dopamine nanocomposite exhibits notable green emission bands at 510, 518, and 527nm which arises from deep-level recombination associated with complex oxygen-related defects like oxygen vacancies. The NiTiO3-dopamine exhibited enhanced antimicrobial activity against S. aureus, B. subtilis, K. pneumoniae, S. dysenteriae, and C. albicans, compared to NiTiO3 alone. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) assays further revealed that NiTiO3dopamine achieved MIC at 600?g/mL and MBC at 1000?g/mL for K. pneumoniae, outperforming pure NiTiO3. ROS assays confirmed oxidative stress-mediated antimicrobial action, with ROS levels significantly quenched in the presence of histidine. SEM images of bacterial morphology showed extensive membrane disruption in NiTiO3dopamine treated cells. Furthermore, zebrafish embryo assays confirmed excellent biocompatibility of the NiTiO3dopamine nanocomposite, with normal development observed up to 72h post fertilization. 2025 Published by Elsevier B.V.
- Source
- Journal of Drug Delivery Science and Technology;Volume;114;Issue;;Article No.;107553;
- Date
- 01-01-2025
- Publisher
- Editions de Sante
- Subject
- Antimicrobial activity; Biocompatibility assay; NiTiO3dopamine nanocomposite; ROS; Zebra fish
- Coverage
- Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
- Rights
- All Open Access; Hybrid Gold Open Access
- Relation
- ISSN: 17732247; CODEN: JDDSA
- Format
- online
- Language
- English
- Type
- Article
Collection
Citation
Thangavelu, Indumathi; Tadepalli, Srinivas, “Biocompatible NiTiO3Dopamine nanocomposites for combating drug-resistant pathogens through membrane disruption and oxidative stress,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22331.