ItemArticle

Green synthesis of biocompatible sodium alginate-coated bismuth oxide nanoparticles using Bougainvillea glabra flower extract with enhanced activity against pathogenic microorganisms and HT-29 colorectal cancer cells

Title
Green synthesis of biocompatible sodium alginate-coated bismuth oxide nanoparticles using Bougainvillea glabra flower extract with enhanced activity against pathogenic microorganisms and HT-29 colorectal cancer cells
Creator
Pradeep, Lakshmi; Tadepalli, Srinivas; Thangavelu, Indumathi; Sarma, Rajat Swaminathan; Boopathi, Thalakulam Shanmugam; Gadallah, Abdelrahman G.
Description
Colorectal cancer is a leading cause of cancer-related deaths, highlighting the urgent need for effective treatments. Similarly, rising antibiotic resistance emphasizes the demand for new antimicrobial drugs. In response, the present study uses Bougainvillea glabra (B. glabra) as a capping agent to synthesis sodium alginate-doped bismuth oxide (SABO) and environmentally friendly bismuth oxide (BO). SABO exhibited smaller particle size (25 nm) and higher crystallinity compared to BO (42 nm). SEM analysis revealed rock-stone-like morphology with average particle sizes of 42 nm for BO and 25 nm for SABO, indicating smaller and better-dispersed particles in SABO. UVVis DRS analysis showed a red shift in absorbance from 387 nm (BO) to 397 nm (SABO) and a band gap decrease from 2.7 eV to 2.3 eV, suggesting enhanced electronic conductivity and increased reactive oxygen species (ROS) generation. Gram-positive bacteria (S. aureus and S. pneumoniae), Gram-negative bacteria (E. coli and K. pneumoniae), and fungi (C. albicans) were all tested for antibacterial activity using BO and SABO. With minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 800 and 1000 g/mL, respectively, SABO showed more activity in the zone of inhibition than the other nanoparticles. Furthermore, the anticancer activity of BO and SABO against HT-29 colorectal cancer cells showed greater efficacy for SABO, with a lower IC50 concentration of 8.1 ?g/mL. These findings suggest that SABO could serve as a multifunctional antimicrobial and anticancer agent in the biomedical field. 2026 Elsevier B.V.
Source
Journal of Molecular Structure;Volume;1360;Issue;;Article No.;145565;
Date
01-01-2026
Publisher
Elsevier B.V.
Subject
Anticancer activity; Antimicrobial acitivity; Bismuth oxide; Bougainvillea glabra; Sodium alginate doped bismuth oxide
Coverage
Pradeep L., Department of Chemistry, Amrita School of Physical Sciences Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India, Functional Materials Laboratory, Amrita School of Engineering Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Sarma R.S., Department of Chemistry, Amrita School of Physical Sciences Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India, Functional Materials Laboratory, Amrita School of Engineering Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India; Boopathi T.S., Department of Chemistry, Amrita School of Physical Sciences Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India, Functional Materials Laboratory, Amrita School of Engineering Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India; Gadallah A.G., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 222860; CODEN: JMOSB
Format
online
Language
English
Type
Article

Citation

Pradeep, Lakshmi; Tadepalli, Srinivas; Thangavelu, Indumathi; Sarma, Rajat Swaminathan; Boopathi, Thalakulam Shanmugam; Gadallah, Abdelrahman G., “Green synthesis of biocompatible sodium alginate-coated bismuth oxide nanoparticles using Bougainvillea glabra flower extract with enhanced activity against pathogenic microorganisms and HT-29 colorectal cancer cells,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 19, 2026, https://archives.christuniversity.in/items/show/22411.

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