ItemArticle

Development of biocompatible NiTi@?-TCP nanocomposite with improved antibacterial and anticancer activities for bone-related biomedical applications

Title
Development of biocompatible NiTi@?-TCP nanocomposite with improved antibacterial and anticancer activities for bone-related biomedical applications
Creator
Bhran, Ahmed A.; Ben Hamida, Mohamed Bechir; Thangavelu, Indumathi; Tadepalli, Srinivas
Description
In the present study, ?-TCP and NiTi@?-TCP nanocomposite were synthesized using a modified solgel method. DLS analysis revealed hydrodynamic particle sizes of ?290 nm for ?-TCP and ?231 nm for NiTi@?-TCP, suggesting improved dispersion after NiTi modification. Optical studies showed a red shift in UVVis absorption from 321 nm (?-TCP) to 396 nm (NiTi@?-TCP) with a reduced band gap from 3.8 eV to 3.1 eV, indicating enhanced electronic interactions. Morphological analysis using SEM and HRTEM revealed nanoscale particles (?1530 nm) with clear lattice fringes and polycrystalline diffraction patterns. The NiTi@?-TCP nanocomposite exhibited enhanced antibacterial activity against S. aureus, S. pneumoniae, K. pneumoniae, and Escherichia coli, producing inhibition zones of 17, 13, 14, and 12 mm, respectively, compared with approximately 10 mm for pure ?-TCP. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values for S. aureus were 0.3 mg mL? and 0.5 mg mL? for NiTi@?-TCP, respectively, which were lower than those of ?-TCP (MIC 0.5 mg mL?; MBC 0.7 mg mL?). Histidine scavenger experiments demonstrated that reactive oxygen species (ROS) play a dominant role in bacterial inhibition. Biocompatibility studies using L929 fibroblast cells showed high cell viability (>87% at 150 ?g mL?), confirming good cytocompatibility. In contrast, the nanocomposite exhibited enhanced anticancer activity against MG-63 osteosarcoma cells, with an IC?? value of 115 ?g mL?, compared with 138 ?g mL? for ?-TCP. These results demonstrate that NiTi@?-TCP nanocomposite possesses improved antibacterial and anticancer properties while maintaining good biocompatibility, making it a promising multifunctional biomaterial for biomedical and bone-related therapeutic applications. 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Source
Journal of Molecular Structure;Volume;1368;Issue;;Article No.;146297;
Date
01-01-2026
Publisher
Elsevier B.V.
Subject
Antibacterial activity; Bone cancer therapy; Cytocompatibility; MG-63 osteosarcoma cells; NiTi coated ?-TCP nanocomposite; Reactive oxygen species; ?-Tricalcium phosphate
Coverage
Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Ben Hamida M.B., Deanship of Scientific Research, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 222860; CODEN: JMOSB
Format
online
Language
English
Type
Article

Citation

Bhran, Ahmed A.; Ben Hamida, Mohamed Bechir; Thangavelu, Indumathi; Tadepalli, Srinivas, “Development of biocompatible NiTi@?-TCP nanocomposite with improved antibacterial and anticancer activities for bone-related biomedical applications,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22412.

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