ItemArticle

Thermosensitive In-situ gel based on halloysite nanotube/chitosan for site-specific delivery of aceclofenac

Title
Thermosensitive In-situ gel based on halloysite nanotube/chitosan for site-specific delivery of aceclofenac
Creator
Singha, Souvik; Chellathurai, Melbha Starlin; Mahmood, Syed; Romero, Eder Lilia; Randhawa, Jaspreet Kaur; Kumar, Mohit; Thomas, Sabu; Chen, Wen-Cheng; Ghosal, Kajal
Description
Periodontitis, a severe and chronic inflammatory gum disease, necessitates the development of advanced drug delivery strategies due to the limitations of conventional therapies, such as rapid drug clearance and inadequate site-specific retention. This study addresses these challenges by formulating and evaluating a novel aceclofenac-loaded halloysite nanotube (HNT) In-situ gel designed for effective local treatment of periodontitis. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID) known for its potent anti-inflammatory action and reduced gastrointestinal side effects, was encapsulated within HNTs to achieve sustained drug release and enhanced therapeutic efficacy. These drug-loaded HNTs were subsequently incorporated into a thermosensitive In-situ gelling system composed of medium molecular weight chitosan, sodium bicarbonate, and sodium ?-glycerophosphate. This gel formulation demonstrated favourable properties, including syringeability, swelling capacity, and temperature-responsive gelation at physiological conditions. The comprehensive characterization techniques such as FTIR, SEM, TEM, PXRD, DSC/TGA, confirmed successful drug encapsulation, structural stability, and uniform distribution within the gel matrix. The in vitro release studies revealed a sustained drug release profile, following zero-order and KorsmeyerPeppas kinetics, indicative of a Super Case-II transport mechanism. This novel, thermoresponsive local drug delivery system shows strong potential to improve the clinical management of periodontitis by providing prolonged therapeutic action, targeted delivery, and improved patient compliance. 2026 American Pharmacists Association.
Source
Journal of Pharmaceutical Sciences;Volume;115;Issue;5;Article No.;104228;
Date
01-01-2026
Publisher
Elsevier B.V.
Subject
Aceclofenac; Chitosan; Halloysite nanotube; In-situ gel; Periodontitis
Coverage
Singha S., Department of Pharmaceutical Technology, Jadavpur University, India; Chellathurai M.S., Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, 50603, Malaysia, Department of Pharmaceutics, School of Pharmacy, Joy University, Raja Nagar, Vaddakkankulam, Tamil Nadu, Tirunelveli, 627116, India; Mahmood S., Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, 50603, Malaysia, Universiti Malaya Research Centre for Biopharmaceuticals and Advanced Therapeutics (UBAT), Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Pathum Wan, 10330, Thailand; Romero E.L., Nanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Saenz Pe 352, Bernal, 1876, Argentina; Randhawa J.K., School of Mechanical & Materials Engineering, Indian Institute of Technology Mandi, India; Kumar M., Chitkara College of Pharmacy, Chitkara University, Punjab, Rajpura, 140401, India; Thomas S., IIUCNN, Mahatma Gandhi University, Kerala, Kottayam, 686 560, India, Department of Physics and Electronics, CHRIST (Deemed to Be University), Karnataka, Bengaluru, 560029, India, Department of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Johannesburg, Doornfontein, 2028, South Africa; Chen W.-C., Department of Fiber and Composite Materials, Feng Chia University, Taichung, 407, Taiwan, Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 807, Taiwan, School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan; Ghosal K., Department of Pharmaceutical Technology, Jadavpur University, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 223549; CODEN: JPMSA
Format
online
Language
English
Type
Article

Citation

Singha, Souvik; Chellathurai, Melbha Starlin; Mahmood, Syed; Romero, Eder Lilia; Randhawa, Jaspreet Kaur; Kumar, Mohit; Thomas, Sabu; Chen, Wen-Cheng; Ghosal, Kajal, “Thermosensitive In-situ gel based on halloysite nanotube/chitosan for site-specific delivery of aceclofenac,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22480.

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