ItemArticle

One pot synthesis of a novel bioactive compound employing a deep eutectic solvent grafted MWCNT system in a solventless environment

Title
One pot synthesis of a novel bioactive compound employing a deep eutectic solvent grafted MWCNT system in a solventless environment
Creator
Veigas, Laveena Mariet; Ravi, Lokesh; Santhosh, G.; Kumar, Lokesh S.; Chandra, P. Nikhil; Mohan, Mothi Krishna
Description
Heterogeneous catalysis is considered as a suitable alternative to conventional organic synthesis for the selective production of industrially significant fine chemicals. The development of supported catalysts by dispersing minimal quantities of active component can reduce production costs and enhance energy efficiency. The current work reports the development of Deep eutectic solvent (DES) modified multiwalled carbon nanotube (MWCNT) system and its activity in the Knoevenagel condensation reaction. The catalytic system was developed by grinding a very low concentration (0.83mM) of DES with desired amount of MWCNT. Various interactions of the three component DES with MWCNT were analysed by X-ray photoelectron spectroscopy (XPS). The reaction favoured a novel compound selectively with yield around 92% in solvent free medium. Anti-cancerous studies of the synthesized compound demonstrated a strong IC50 value of 15.62g/ml and a statistically calculated IC50 value of 9.8g/ml. Acridine orange/ Ethidium Bromide (AO/EB) dual fluorescence staining studies revealed that the test ligand with lowest concentration of 7.8g/ml was capable to induce apoptosis in 100% of MCF-7 cells. It is evident from the studies that the synthesized compound is a strong anticancer agent with potential to be investigated further. The Author(s) 2025.
Source
Scientific Reports;Volume;15;Issue;1;Article No.;26100;
Date
01-01-2025
Publisher
Nature Research
Subject
Cytotoxicity; Deep eutectic solvent; Grafting; Knoevenagel condensation; MWCNT
Coverage
Veigas L.M., Department of Sciences and Humanities, School of Engineering and Technology, Christ University, Karnataka, Bengaluru, India, St Josephs University, 36 Lalbagh Road, Karnataka, Bengaluru, 560027, India; Ravi L., Department of Biomedical Sciences, School of Health Sciences, The Apollo University, Andra Pradesh, Chittoor, 517127, India, Centre for Digital Health and Precision Medicine, The Apollo University, Andra Pradesh, Chittoor, 517127, India; Santhosh G., Department of Sciences and Humanities, School of Engineering and Technology, Christ University, Karnataka, Bengaluru, India; Kumar L.S., Department of Sciences and Humanities, School of Engineering and Technology, Christ University, Karnataka, Bengaluru, India; Chandra P.N., P.G. and Research Department of Chemistry, Sree Narayana College, Kerala, Kollam, 691001, India; Mohan M.K., Department of Sciences and Humanities, School of Engineering and Technology, Christ University, Karnataka, Bengaluru, India
Rights
All Open Access; Gold Open Access; Green Open Access
Relation
ISSN: 20452322;
Format
online
Language
English
Type
Article

Citation

Veigas, Laveena Mariet; Ravi, Lokesh; Santhosh, G.; Kumar, Lokesh S.; Chandra, P. Nikhil; Mohan, Mothi Krishna, “One pot synthesis of a novel bioactive compound employing a deep eutectic solvent grafted MWCNT system in a solventless environment,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22524.

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