Designing in situ nanostructured MWCNT-phloroglucinol modified webs for electrochemical-based dual screening of stress biomarkers
- Title
- Designing in situ nanostructured MWCNT-phloroglucinol modified webs for electrochemical-based dual screening of stress biomarkers
- Creator
- Gandhi, Mansi; Varghese, Anitha
- Description
- Phloroglucinol (PG), or benzene 1,3,5-triol, is an essential phenolic compound and a vital tannin. In this study, we developed a tannin-phloroglucinol (PG) derived redox mediator for the detection of glutathione (GT) and H2O2 on a glassy carbon electrode (GCE) modified with a multiwalled-chitosan composite. The PG redox platform was prepared using a cyclic voltammetric approach in pH 7 aqueous buffer media without any additional surfactant/chemical moieties. A highly stable, fouling-free surface confined redox characteristic was observed at an apparent electrode potential of E0? = ?0.196 V (A1/C1) and 0.05 V (A2/C2) vs. Ag/AgCl was observed. The as-prepared electrochemical platform achieved an ultra-low limit of detection (LOD) for glutathione (GT) of 0.16 M and LOQ of 2.08 M using a sustainable platform. In addition, it exhibited high selectivity for GT in the presence of various interfering analytes. In addition, the modified platform was extended to hydrogen peroxide (H2O2) sensing at ?0.196 V vs. Ag/AgCl with a LOD of 5.4 M in PBS buffer media at v = 10 mV s?1. The GCE/MWCNT-Chit@PG-Redox demonstrated robust performance in a proof-of-concept experiment for analyzing GT and H2O2 in real samples using a standard addition approach with good recovery values. This journal is the Owner Societies, 2026
- Source
- Physical Chemistry Chemical Physics;Volume;28;Issue;6;pp.4111-4124
- Date
- 01-01-2026
- Publisher
- Royal Society of Chemistry
- Coverage
- Gandhi M., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bengaluru, 560029, India; Varghese A., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bengaluru, 560029, India
- Rights
- Restricted Access; Hardcopy may be available in the library
- Relation
- ISSN: 14639076; CODEN: PPCPF
- Format
- online
- Language
- English
- Type
- Article
Collection
Citation
Gandhi, Mansi; Varghese, Anitha, “Designing in situ nanostructured MWCNT-phloroglucinol modified webs for electrochemical-based dual screening of stress biomarkers,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22552.