ItemArticle

Design and synthesis of bioactive Ru(II) complexes: antibacterial activity, biocompatibility and biomolecular binding

Title
Design and synthesis of bioactive Ru(II) complexes: antibacterial activity, biocompatibility and biomolecular binding
Creator
Bhunya, Debasis; Datta, Riya; Maity, Ribhu; Saha, Alipe; Sen, Sujata; Brandao, Paula; Pattanayak, Satyajit; Maity, Tithi; Sarkar, Keka; Samanta, Bidhan Chandra
Description
Ruthenium(ii) complexes with N- and S-donor ligands have emerged as promising alternatives to conventional antibiotics due to their stability, biocompatibility, and ability to interact with biological macromolecules. In this work, a series of four Ru(ii)thiazolidine complexes, [Ru(ii)(L1L4)(p-cymene)Cl]PF6, were synthesized and structurally characterized using spectroscopic techniques and X-ray crystallography. Their interactions with DNA and proteins showed partial groove binding with calf thymus DNA and a static quenching mechanism with bovine serum albumin (BSA). Biological investigations revealed that two of the complexes exhibited strong antioxidant activity and significant antibacterial effects against methicillin-resistant Staphylococcus aureus (MRSA) and Klebsiella pneumonia (KP). Moreover, hemolysis assays confirmed their favourable biocompatibility. These results highlight Ru(ii)thiazolidine frameworks as promising candidates for antimicrobial drug development. This study not only underscores their therapeutic potential but also advances the role of ruthenium-based coordination chemistry in addressing the persistent challenge of antibiotic resistance. This journal is The Royal Society of Chemistry, 2025
Source
RSC Advances;Volume;15;Issue;50;pp.42573-42587
Date
01-01-2025
Publisher
Royal Society of Chemistry
Coverage
Bhunya D., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Datta R., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Maity R., Department of Chemistry, Mugberia Gangadhar Mahavidyalaya, Bhupatinagar, Purba Medinipur, West Bengal, 721425, India; Saha A., Department of Microbiology, University of Kalyani, West Bengal, India; Sen S., Department of Microbiology, University of Kalyani, West Bengal, India; Brandao P., Departamento de Quica, CICECO, Universidade de Aveiro, Aveiro, 3810-193, Portugal; Pattanayak S., Department of Chemistry, Mugberia Gangadhar Mahavidyalaya, Bhupatinagar, Purba Medinipur, West Bengal, 721425, India; Maity T., Department of Chemistry, Prabhat Kumar College, Purba Medinipur, West Bengal, Contai, 721401, India; Sarkar K., Department of Microbiology, University of Kalyani, West Bengal, India; Samanta B.C., Department of Chemistry, Mugberia Gangadhar Mahavidyalaya, Bhupatinagar, Purba Medinipur, West Bengal, 721425, India
Rights
All Open Access; Gold Open Access; Green Open Access
Relation
ISSN: 20462069; CODEN: RSCAC
Format
online
Language
English
Type
Article

Citation

Bhunya, Debasis; Datta, Riya; Maity, Ribhu; Saha, Alipe; Sen, Sujata; Brandao, Paula; Pattanayak, Satyajit; Maity, Tithi; Sarkar, Keka; Samanta, Bidhan Chandra, “Design and synthesis of bioactive Ru(II) complexes: antibacterial activity, biocompatibility and biomolecular binding,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/22583.

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