ItemArticle

Engineering Ru(ii) Schiff base complexes as biofunctional materials: cytotoxic and cell imaging perspectives

Title
Engineering Ru(ii) Schiff base complexes as biofunctional materials: cytotoxic and cell imaging perspectives
Creator
Bhunya, Debasis; Datta, Riya; Maity, Swapan; Sahoo, Subhasish; Samanta, Bidhan Chandra
Description
Four bromine-substituted Ru(ii)-arene Schiff base complexes derived from bromo-picolinaldehyde and 3-(1H-pyrazol-1-yl)propan-1-amine were examined for their cytotoxic behaviour toward cervical cancer (SiHa) and normal fibroblast (3T3-L1) cells using MTT-based in vitro assays. The ligands and complexes were comprehensively characterized by FTIR; 1H, 13C, and 19F NMR; and ESI-LCMS analyses. Single-crystal X-ray diffraction (SCXRD) confirmed the molecular structure of complex 3, while PXRD validated the crystalline nature of complexes 2 and 4. Density functional theory (DFT) calculations further supported the experimental data by revealing optimized geometries and key electronic descriptors. All complexes exhibited time- and dose-dependent anticancer effects, with complexes 24 showing the greatest cytotoxicity toward the SiHa cells (viability at 72 h: 20% 3%, 31% 3%, and 29% 3%, respectively) while maintaining high viability in normal fibroblasts (>90%). The IC50 values for complexes 14 were 19.54 2, 14.21 4, 12.43 4, and 12.43 4 M, respectively. Acridine orange (AO) and ethidium bromide (EtBr) staining and morphological analyses confirmed apoptosis as the primary mechanism of cell death, as evidenced by reduced adhesion, membrane blebbing, and cell rounding. The pronounced and selective cytotoxicity of these bromine-substituted Ru(ii) complexes highlights their potential as promising biomaterial candidates for targeted anticancer therapy. This journal is The Royal Society of Chemistry and the Centre National de la Recherche Scientifique, 2026
Source
New Journal of Chemistry;Volume;50;Issue;12;pp.5266-5276
Date
01-01-2026
Publisher
Royal Society of Chemistry
Coverage
Bhunya D., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Datta R., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Maity S., School of Materials Science and Technology, Indian Institute of Technology (IIT), BHU, Varanasi, India; Sahoo S., Department of Chemistry, National Institute of Technology, Rourkela, 769008, India; Samanta B.C., Department of Chemistry, Mugberia Gangadhar Mahavidyalaya, Bhupatinagar, Purba Medinipur, West Bengal, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 11440546; CODEN: NJCHE
Format
online
Language
English
Type
Article

Citation

Bhunya, Debasis; Datta, Riya; Maity, Swapan; Sahoo, Subhasish; Samanta, Bidhan Chandra, “Engineering Ru(ii) Schiff base complexes as biofunctional materials: cytotoxic and cell imaging perspectives,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 17, 2026, https://archives.christuniversity.in/items/show/22605.

Output Formats