ItemArticle

Extended-spectrum ?-Lactamase (ESBL) Producing Bacterial Pathogens Associated with Respiratory Tract Infections

Title
Extended-spectrum ?-Lactamase (ESBL) Producing Bacterial Pathogens Associated with Respiratory Tract Infections
Creator
Lakshman, Priyanka; Mayegowda, Shilpa Borehalli; Gadilingappa, Manjula Nagalapur
Description
Respiratory tract infections (RTIs) have been critically associated with health care problems globally. Subsequently, increased antibiotic resistance rates have limited treatment options that are further exaggerated due to lack of newer novel drugs and therapies. Current study highlights, antibiotic resistance profiling along with extended-spectrum beta-lactamase (ESBL) producers of RTI pathogens from Bengaluru. During June 2020-May 2021, 1016 clinical samples collected, prevalence rate of 22.4% was exhibited, with highest in male (74.5%). Following age group, 30-35 years displayed highest (24.1%) though, lowest was in 45-50 years (1.3%). The standard microbiological characterization revealed Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii as predominant bacterial pathogens associated with RTIs. While, Antibiotic susceptibility test (AST) exhibited highest resistance rates for different antibiotics in the following pathogens, as K. pneumoniae for ampicillin (74.8%), P. aeruginosa for doripenem (66.6%), A baumannii to piperacillin/tazobactam (76.9%), E. coli for penicillin and ?-lactamase inhibitors ranging between 56-92%, E. cloacae to ticarcillin/clavulanic acid besides cefuroxime (100%). However, prevalence of Gram-positive strains were lowest and exhibited highest resistance to penicillin, and fluoroquinolone (83.3%). ESBL producers were predominantly K. pneumoniae, followed by E. coli, and E. cloacae with 21.9%, 6.5% and 1.3%, respectively. Notably, all the Gram-negative strains showed 100% sensitivity towards colistin with remarkable sensitivity was observed in oxazolidinone, glycopeptides by S. aureus and Coagulase-neagtive Staphylococcus aureus (CoNS). The study emphasizes increased antimicrobial resistance antimicrobial and ESBL resistance, suggesting AST as a systematic approach for apprising treatment guidelines in current scenario. The present study denotes polypeptide colistin as choice of drugs for treating RTI pathogens, however its not recommended in all cases. The Author(s) 2025.
Source
Journal of Pure and Applied Microbiology;Volume;19;Issue;1;pp.601-616
Date
01-01-2025
Publisher
Journal of Pure and Applied Microbiology
Subject
Antibiotic Resistance; Colistin; Extended-spectrum beta-lactamase; Respiratory Tract Infections
Coverage
Lakshman P., Department of Microbiology, School of Basic and Applied Sciences, Dayananda Sagar University, Bengaluru, India; Mayegowda S.B., School of Psychological Sciences, CHRIST University, Kengeri Campus, Bengaluru, India; Gadilingappa M.N., Department of Microbiology, School of Basic and Applied Sciences, Dayananda Sagar University, Bengaluru, India
Rights
All Open Access; Gold Open Access; Green Open Access
Relation
ISSN: 9737510;
Format
online
Language
English
Type
Article

Citation

Lakshman, Priyanka; Mayegowda, Shilpa Borehalli; Gadilingappa, Manjula Nagalapur, “Extended-spectrum ?-Lactamase (ESBL) Producing Bacterial Pathogens Associated with Respiratory Tract Infections,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/23405.

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