ItemArticle

Characterization, molecular docking, and therapeutic properties of biomaterial obtained from Pangasianodon hypopthalmus

Title
Characterization, molecular docking, and therapeutic properties of biomaterial obtained from Pangasianodon hypopthalmus
Creator
Meganathan, Gomathy; Pappuswamy, Manikantan
Description
The therapeutic properties of fish have been recognized since ancient times because of the presence of various fatty acids. Oleic acid, which is a mono-unsaturated fatty acid, is known for curing heart-related diseases and promoting brain health. Our study is a first attempt to evaluate the Anti-inflammatory activity, Anti-oxidant activity and perform characterization studies on mucus obtained from Pangasianodon hypopthalmus and explore its therapeutic properties. Anti-inflammatory property evaluation was performed via, albumin denaturation assay showing an 81% inhibition rate and RBC hemolysis assay with a 76.79% inhibition rate, anti-oxidant activity evaluation performed using the DPPH assay showed an 80% radical scavenging activity at 150?g/mL concentration. Overall results showed that anti-inflammatory was highest at 100mg/mL concentration and anti-oxidant activity was highest at 150?g/mL concentration. Characterization studies involved FTIR, NMR and GCMS analysis. Simulation study was performed on selected compound (ligand) against selected targets. From GC-MS analysis, C18 H34 O2 (Oleic acid), was found to be present at higher concentration. Docking studies revealed good binding energy and strong hydrogen bonding between oleic acid and TNF-?, with a binding energy of ?5.3 kcal/mol, thereby demonstrating strong anti-inflammatory activity and wound-healing potency. Further in-vitro and in-vivo analysis has to be performed to develop potential drug for therapeutic purpose. 2026 Visagaa Publishing House.
Source
Natural Resources for Human Health;Volume;6;Issue;1;pp.40-56
Date
01-01-2026
Publisher
Visagaa Publishing House
Subject
Anti-inflammatory property; Biomaterial characterization; Molecular docking studies bioactive compounds; Pangasianodon hypopthalmus
Coverage
Meganathan G., Department of Life Sciences, Christ University (Deemed to be University), Bengaluru, India; Pappuswamy M., Department of Life Sciences, Christ University (Deemed to be University), Bengaluru, India
Rights
All Open Access; Hybrid Gold Open Access
Relation
ISSN: 25831194;
Format
online
Language
English
Type
Article

Citation

Meganathan, Gomathy; Pappuswamy, Manikantan, “Characterization, molecular docking, and therapeutic properties of biomaterial obtained from Pangasianodon hypopthalmus,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 19, 2026, https://archives.christuniversity.in/items/show/23674.

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