ItemBook Chapter

Targeting Metabolic Reprogramming: A New Frontier in Cancer Therapy

Title
Targeting Metabolic Reprogramming: A New Frontier in Cancer Therapy
Creator
Thakur, Ravi; Kumari, Niti
Description
Cancer cells undergo profound metabolic reprogramming to meet the high demands of unchecked proliferation within the nutrient-limited tumor microenvironment (TME). While fundamental metabolic pathways are conserved, cancer cells exhibit distinct metabolic fluxes and substrate preferences, meticulously dictated by genetic, epigenetic, and microenvironmental cues that reshape enzyme and transporter profiles. This metabolic rewiring sculpts the TME, fostering both competition and cooperation, often favoring tumor-promoting stromal components (cancer-associated fibroblasts, M2 tumor-associated macrophages), and hinders antitumor immunity. Targeting aberrant cancer metabolism and originating interactions in TME presents a promising therapeutic avenue. However, the inherent metabolic heterogeneity across malignancies necessitates personalized combination therapies and continued research to efficiently target this key cancer hallmark. 2025 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
Source
Molecular Targets in Cancer Therapy: Understanding Cellular Pathways for Therapeutic Interventions;pp.201-226
Date
01-01-2025
Publisher
Springer Science+Business Media
Subject
Cancer; Metabolic reprogramming; Metabolic targeting; Tumor microenvironment
Coverage
Thakur R., Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States, Department of Life Sciences, Christ University, Bengaluru, India; Kumari N., Biomedical Sciences Department, Creighton University School of Medicine, Omaha, NE, United States
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISBN: 978-981967336-0; 978-981967335-3;
Format
online
Language
English
Type
Book chapter

Citation

Thakur, Ravi; Kumari, Niti, “Targeting Metabolic Reprogramming: A New Frontier in Cancer Therapy,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/24157.

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