Psychoneuroimmunology in the context of dementia

Title

Psychoneuroimmunology in the context of dementia

Creator

Mayegowda, Shilpa Borehalli; Donni, Sacheth Kiran; Patnaik, Aditi; Prince, Kevin

Description

Dementia is a neurodegenerative condition that affects a multitude of cognitive functions. This chapter delves into the vulnerabilities and risk factors associated with aging that can lead to dementia. Aging brings a higher risk of depression and anxiety. The chapter uses the framework of psychoneuroimmunology to explain how psychological states during old age and after the diagnosis of dementia result in immune consequences. The consequences of dementia on daily functioning result in disturbances in sleep, appetite, mobility, sociability, and overall activities of daily living. Impairments in these areas cause increased reliance on caregivers to fulfill daily needs. These disturbances are accompanied by an overactivation of the HPA axis, impairments in glial cell functioning, disturbed glucocorticoid and mineralocorticoid functioning, a compromised gut-brain axis, and an overall increase in the release of proinflammatory cytokines. These physiological changes consequently increase neuroinflammation accelerating the progression of dementia. 2025 by IGI Global Scientific Publishing. All rights reserved.

Source

Research Methodologies and Practical Applications in Psychoneuroimmunology;pp.293-321

Date

01-01-2025

Publisher

IGI Global

Coverage

Mayegowda S.B., Christ University, India; Donni S.K., Christ University, India; Patnaik A., Christ University, India; Prince K., Christ University, India

Rights

Restricted Access; Hardcopy may be available in the library

Relation

ISBN: 979-836937434-4; 979-836937432-0;

Format

online

Language

English

Type

Book chapter

Identifier

https://doi.org/10.4018/979-8-3693-7432-0.ch014

https://www.scopus.com/pages/publications/105003144553?origin=resultslist