Psycho-neuroendocrine regulation of autoimmune dysfunction in polycystic ovary syndrome

Title

Psycho-neuroendocrine regulation of autoimmune dysfunction in polycystic ovary syndrome

Creator

Jeni, Alana; Jayasankara Reddy, K.

Description

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 8-13% of women of reproductive age, marked by hormonal imbalances, insulin resistance, including various metabolic and reproductive issues. Psychological stress plays a crucial role in PCOS, acting as both a trigger and a maintaining factor. This review focused on outlining how psychological stress may disrupt the hypothalamic-pituitary-adrenal (HPA) axis, leading to dysfunction in endocrine and immunological systems. The review has highlighted how glucocorticoids impair hormonal equilibrium and exacerbate immune dysfunction in PCOS. Additionally, the review examines the association between PCOS and various autoimmune conditions. There exists a complex interaction between psychological stress, neuroendocrine disruption, and immune dysfunction in PCOS. Understanding these relationships is essential for developing more effective management strategies and addressing the broader health implications of the syndrome. 2025 by IGI Global Scientific Publishing. All rights reserved.

Source

Research Methodologies and Practical Applications in Psychoneuroimmunology;pp.483-499

Date

01-01-2025

Publisher

IGI Global

Coverage

Jeni A., Christ University, India; Jayasankara Reddy K., Christ University, India

Rights

Restricted Access; Hardcopy may be available in the library

Relation

ISBN: 979-836937434-4; 979-836937432-0;

Format

online

Language

English

Type

Book chapter

Identifier

https://doi.org/10.4018/979-8-3693-7432-0.ch021

https://www.scopus.com/pages/publications/105003270833?origin=resultslist