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Inter-relational dynamics of factors affecting the emergence of orphan drugs; [Dynamique interrelationnelle des facteurs influennt lergence des micaments orphelins]
Orphan drugs are medications that are produced for the treatment of rare diseases. As there is less number of patients, the drug manufacturing companies are not keen in producing these drugs. Due to high costs of research and development and low profitability, companies do not want to invest in manufacturing of orphan drugs. Several laws have been passed by Governments of different nations to encourage the development of orphan drugs and make it available to patients. This study explores the interrelation dynamics of factors that has resulted in the greater availability of orphan drugs in recent times. Ten factors: internet technology, legislation, online patient support groups, government subsidiary, biotechnological advancements, corporate social responsibility, awareness and diagnosis of rare diseases and exclusive budgeting by pharmaceutical industries for orphan drugs related research and development and production were taken for the study. With a sample size of 38 experts, the technique of decision-making trial and evaluation laboratory (DEMATEL) was used for the study. It was found that information technology, legislation, support groups, and budget were the causes and the factors awareness, diagnosis, medicine availability, subsidiary, CSR and biotechnology emerged to be the effect. 2024 Acadie Nationale de Pharmacie -
Inter-state Disparities in Health Care Facilities During COVID-19: A Study of Ayushman Bharat Pradhan Mantri Jan Arogya Yojana (AB PM-JAY) in India
Universal Health Coverage (UHC) is one of the primary agendas of the World Health Organization (WHO) for achieving the goal of sustainable development. Ayushman Bharat Pradhan Mantri Jan Arogya Yojana (AB PM-JAY) is an important landmark in Indias road towards achieving this objective of universal health. The scheme aims to provide access to quality healthcare services through its empanelled public and private hospitals at the secondary and tertiary care levels. The current study attempts to understand the interstate disparities amongst the states using the scheme during COVID-19, and also analyses the interrelationship between the status of COVID-19 and PM-JAY-empanelled health infrastructure. The study has used secondary data from the COVID-19 India dashboard and the PM-JAY website for the analysis. The study found that, despite having an overall positive correlation between the number of COVID cases and the number of beneficiaries treated, there still exist wide disparities among the states in availing treatment. It was also evident that there is no significant relationship between the status of COVID-19 and the empanelled health infrastructure under PM-JAY. The states with a high number of health infrastructure, with high death and fewer recovery cases, had the worst COVID-19 situation. In order to have better utilisation of the scheme, the government can take necessary measures, such as broader coverage of the scheme, sufficient budgetary allocation to the states, and investment in additional private health infrastructure. 2026 Indian Institute of Health Management Research -
Inter-State Migration, Footloose Labour and Accessibility to Health Care: An Exploration among Metro Workers of a Camp in Bengaluru
The neoliberal political economy that India adopted in 1991 has brought in huge Foreign Direct Investments, which has led to a perceptible increase in the number of migrants in the major cities of India due to various structural reasons in their place of origin and rapid developmental activities in the cities. Bengaluru has the second largest migrant population after Mumbai, and as per the labour department of the government of Karnataka; there are more than 65 lakh migrant workers in Karnataka, who are involved in various developmental projects, including the metro railway project in Bangalore. Even though the Karnataka Building and Other Construction Workers Welfare Board (KBOCWWB) offers certain social security, including health care for registered migrants, they must wait more than a year to get these benefits. With privatisation and increased out-of-pocket expenditure for health related issues, the migrants face a major hurdle in surviving at the migrated workplaces. Many of them are unaware of welfare boards, and the number of migrants who are registered with them is very small. This paper aims to understand the accessibility of health facilities for migrant workers working in the Bengaluru Metro Project. This research will understand the legal, economic and psychological aspects related to the health status of migrant workers through qualitative study. The study used in-depth interviews to elicit responses from selected inter-state migrant workers to understand their access towards health facilities. The thematic analysis of the interview transcripts revealed a substantive gap in workers access to health facilities. The unregulated working conditions have added more stress to the workers, and due to poverty and unemployment back home, these hurdles are not forcing them to go back. More awareness creating interventions from the government can transform their lives. (2024), (University of Duisburg). All rights reserved. -
Interacting Dark Energy and Its Implications for Unified Dark Sector
Alternative dark energy models were proposed to address the limitation of the standard concordance model. Though different phenomenological considerations of such models are widely studied, scenarios where they interact with each other remain unexplored. In this context, we study interacting dark energy scenarios (IDEs), incorporating alternative dark energy models. The three models that are considered in this study are time-varying ?, Generalized Chaplygin Gas (GCG), and K-essence. Each model includes an interaction rate ? to quantify energy density transfer between dark energy and matter. Among them, GCG coupled with an interaction term shows promising agreement with the observed TT power spectrum, particularly for ?<70, when ? falls within a specific range. The K-essence model (??0.1) is more sensitive to ? due to its non-canonical kinetic term, while GCG (??1.02) and the time-varying ? (??0.01) models are less sensitive, as they involve different parameterizations. We then derive a general condition when the non-canonical scalar field ? (with a kinetic term Xn) interacts with GCG. This has not been investigated in general form before. We find that current observational constraints on IDEs suggest a unified scalar field with a balanced regime, where it mimics quintessence behavior at n<1 and phantom behavior at n>1. We outline a strong need to consider alternative explanations and fewer parameter dependencies while addressing potential interactions in the dark sector. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. -
Interaction of Generational Differences with Gender and Residential Nature in Attitudes Toward Interfaith Marriages
The present study examined the interaction effects of generations, gender, and residential nature on attitudes toward interfaith marriage in a sample of 1190 Indian participants from iGen, Xennials and Millennials, and Baby Boomers generations. Data were collected using a socio-demographic response sheet and the Attitude Scale, with lower ratings indicating positive attitudes and higher ratings indicating negative attitudes. The results of this study demonstrated that generational differences are significantly associated with gender and residential nature. There was a significant interaction between generation and gender and generation and residential nature on attitudes toward interfaith marriages. 2024 Taylor & Francis Group, LLC. -
Interaction of Nanomaterials with Plant Macromolecules: Nucleic Acid, Proteins and Hormones
Nanotechnology has the ability to change a wide range of industrial and agricultural operations. To harness these possibilities, it is essential to construct nano-materials that have minimum impact on the human body, plant systems as well as the environment. Using different materials can up-or down-regulate diverse genes of plants, create stimulating or stressful conditions and even cause production of metabolites that affect plant-associated microbes. The same nanoparticle can promote one plant species growth and be toxic to another. A small change in the concen-trations could cause either flourishment or senescence. It is crucial to understand how nanomaterials interact with nucleic acids, the most fundamental plant macro-molecule, as well as with the proteins and hormones made by biochemical processes. This chapter explores the basics of nanotechnology, with a brief classification and notes on some of the most recently used nanomaterials in agriculture such as metals and their oxides, quantum dots, graphene, arabinoxylan and chitosan nanoparticles, single and multi-walled carbon nanotubes. Interactions with these above-mentioned macromolecules are explored, along with futuristic applications in plants that are currently being tested, like nanocarriers and nanovalves. Through this work, it is hoped that the field will further be extended through proper understanding of the environmental implications of nanomaterials, and that green technology will become the norm. The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023. -
Interactions between emotional and spiritual intelligence and their effects on employee performance
The association among worker behavior, spiritual intelligence, emotional intelligence, and system effectiveness is explained by this study. Understanding how others communicate and being aware of how one's own emotions affect others around you are all characteristics of emotional intelligence. Spiritual intelligence, which is a higher level of intelligence, reveals one's actual attributes and abilities. As company's most asset, the effectiveness of employee behavior has a significant impact on the company's ability to survive and thrive. In contrast to other facets of human conduct, employee conduct is distinguished by more formal behavior. This study aims to determine whether those with emotional and spiritual intelligence perform well at work. This research also aims to comprehend the behavior of emotionally intelligent and spiritually inclined people at work. Attempts are made in this study to ascertain whether higher levels of spiritual and emotional intelligence might boost the efficacy of these abilities. In this study, productivity at work is the dependent variable, whereas emotional intelligence and spiritual intelligence are independent variables. The parameters that can assess the variables were established using a literature review and a few common surveys. An organized survey that considers the variables is developed to gather information from the working class. To determine the link between the variables chosen for this study, the gathered data was analyzed using statistical approaches such as partial correlation and correlation. 2024 Author(s). -
Interactions of Environmental Pollutant Aromatic Amines With Photo Excited States of Thiophene Substituted 1,3,4-Oxadiazole Derivative: Fluorescence Quenching Studies
In the present work, the fluorescence quenching of novel thiophene substituted1,3,4-oxadiazole derivative 2-(4-(4-vinylphenyl) phenyl)-5-(5-(4-vinylphenyl)thiophen-2-yl)-1,3,4-oxadiazole (TSO) by five different environmental pollutant aromatic amine derivatives like 2,4-dimethylaniline, 3-chloroaniline, 4-chloroaniline, o-anisidine, and m-toluidine has been studied at room temperature through steady-state and time-resolved methods. It is observed that, the quenching efficiency is highest in the case of o-anisidine and least in the case of 3-chloroaniline. The fluorescence quenching mechanism between TSO and aromatic amines is analysed through different quenching models. The results suggest that, the fluorescence quenching is due to diffusion assisted dynamic or collisional quenching according to the sphere of action static quenching model and according to the finite sink approximation model, the bimolecular quenching reactions are due to the collective effect of dynamic and static quenching. Further, cyclic voltammetry and DFT studies suggest that the fluorescence quenching is due to electron transfer. Binding equilibria analysis confirms the 1:1 stoichiometric ratio between fluorophore and the quencher. 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. -
Interconnected Dynamics of Gold, Nifty, Crude Oil, and USD/INR: Insights from a Panel Data VAR Analysis
This study utilizes a panel data vector autoregression (PVAR) model to examine the relationships between Gold, Nifty, Crude Oil, and USD/INR, drawing from 3105 observations sourced from Yahoo Finance. Descriptive statistics reveal notable volatility, particularly in Gold and Crude Oil. Unit root tests confirm stationarity, crucial for time series analysis. Optimal lag selection recommends a lag order of 2, balancing model accuracy and complexity. Granger causality tests indicate limited predictive power, with gold influencing USD/INR unidirectionally. Impulse response function analysis and variance decomposition underscore Golds relative independence. Robustness tests affirm stability, highlighting USD/INRs endogeneity. This study enhances understanding of financial dynamics, offering insights for risk management, portfolio diversification, and monetary policy. The Author(s), under exclusive license to Springer Nature Switzerland AG 2025. -
Interconnected Dynamics of Gold, Nifty, Crude Oil, and USD/INR: Insights from a Panel Data VAR Analysis
This study utilizes a panel data vector autoregression (PVAR) model to examine the relationships between Gold, Nifty, Crude Oil, and USD/INR, drawing from 3105 observations sourced from Yahoo Finance. Descriptive statistics reveal notable volatility, particularly in Gold and Crude Oil. Unit root tests confirm stationarity, crucial for time series analysis. Optimal lag selection recommends a lag order of 2, balancing model accuracy and complexity. Granger causality tests indicate limited predictive power, with gold influencing USD/INR unidirectionally. Impulse response function analysis and variance decomposition underscore Golds relative independence. Robustness tests affirm stability, highlighting USD/INRs endogeneity. This study enhances understanding of financial dynamics, offering insights for risk management, portfolio diversification, and monetary policy. The Author(s), under exclusive license to Springer Nature Switzerland AG 2025. -
Interconnected Intelligence: Navigating Through Power Quality Checking and Control Using Smart Intelligence-Based Methods
Globally, power quality issues incur substantial costs. In the United States, power quality problems contribute to a $150 billion annual cost, covering lost productivity, equipment damage, and safety hazards. Smart intelligence-based methods can potentially cut these costs by up to 50%. In India, power quality disturbances result in a $10 billion annual cost involving equipment damage, productivity losses, and customer dissatisfaction. The adoption of smart intelligence-based power quality methods in India is projected to grow annually by 25% for the next 5years due to increasing grid demands. In todays intricate power landscape, dependable electrical systems are crucial. Power quality disturbances, including voltage variations, harmonics, and flicker, can disrupt sensitive equipment, resulting in financial losses and safety risks. Addressing these challenges, smart intelligence-based methods emerge as promising solutions. This chapter systematically explores the application of artificial intelligence, machine learning, and data analytics for elevated power quality monitoring, assessment, and regulation. Such intelligent approaches optimise power system performance, reduce downtimes, and ensure a consistent supply of high-quality electrical energy. The assimilation of smart intelligence-based methods emerges as a promising avenue to address these challenges effectively. Harnessing the capabilities of these intelligent paradigms empower power systems to attain optimal performance, curtail downtimes, and ensure a steadfast provision of high-grade electrical energy. The Author(s), under exclusive license to Springer Nature Switzerland AG 2025. -
Interconnections of yogic practices with mental health
Yoga, an ancient practise of humankind, attempts to promote a lifestyle that is free of maliciousness with emphasis on inculcating qualities that would aid the individual in living a life that is truly actualizing. Practise of yoga is not limited to holding specific asanas but various components of yoga such as pranayama, pratyahara, etc.; all attempt to enhance an individual's wellbeing. The chapter has contextualized yoga therapy including pranayama, mudras, and chakras to biopsychosocial models, and attempted to identify yogic practises that bring holistic enhancement. Yoga, being cost-effective, and having no side effects, unlike pharmacological treatments, can be used as an adjunctive therapeutic agent in improving symptoms or improving mood and reducing stress. However, it is important to note the feasibility and limitations of yoga interventions, like proper trained professionals to minimize any ill effects. The chapter attempted to promote the practise of yoga as an adjunctive form of treatment which would thereby aid in improving biopsychosocial wellbeing. 2024, IGI Global. All rights reserved. -
Interepisodic functioning in patients with bipolar disorder in remission
Background and Objectives: Patients with bipolar disorder (BD), despite recovering symptomatically, suffer from several functional impairments even in remission. The actual causes of impaired functioning are less known. Materials and Methods: The study aimed to examine the clinical and psychosocial determinants of functioning in patients with BD in remission. A cross-sectional single-group design was adopted (n = 150). Participants meeting the study criteria were screened with Mini-International Neuropsychiatric Interview Scale. The selected participants were administered various tools to assess the level of functioning and the clinical, psychosocial determinants of functioning. Results: The clinical characteristics of the sample included early age of onset of illness, presence of precipitating factors, fewer episodes, minimal comorbidities, history of psychotic episodes, family history of mental illness, good medication adherence, and low depression and mania scores. Psychosocial factors included higher stress and moderate social support and self-esteem in the sample. Poor functioning patients had a history of longer hospital stay and had greater scores on depression, mania, stress, and maladaptive coping styles than better functioning patients. Conclusion: Higher depression, mania, stress, and maladaptive coping strategies were related to poor functioning, while higher medication adherence, self-esteem, and social support were related to better functioning. 2018 Indian Psychiatric Society - South Zonal Branch Published by Wolters Kluwer - Medknow. -
Interface between Legal and Moral Implications on Patenting Biotechnological Inventions: A Comparative Analysis of the Patents Law of India, the US and the EU
The biotechnology industry has seen one of the most significant expansions in the Patent Laws. It is challenging for a law to link with protecting the intangible property vested in biotechnology patents, as the biotechnology resources come from living organisms. Patenting biotechnological inventions raises legal, ethical and moral concerns. In the light of the current context, this paper examines patents law of Section 3(b) of the Indian Patents Act, 35 U.S.C Section 101 of the U.S. Patent Law, Article 53(a) of the European Patent Convention and Article 6 of the EU Biotech Directive. The paper compares the legal structure of these three countries, illuminating the similarities and differences in interpreting morality provisions by referring to various case precedents, statutes, and legal references within the patent laws of the United States and the European Union as a benchmark for evaluating Indias patent system. The paper proposes and suggests clarifying morality clauses of the Indian Patents Act to keep up with the advancements in Biotechnology inventions by providing a clear definition of morality and contrary to public order instead of patent controllers exercising their discretionary power unguided. The paper highlights that it is vital to consider moral and ethical implications as biotechnology evolves, ensuring that law and morality should foster a holistic and informed approach to shaping the future of biotechnological inventions in a global context. 2025, National Institute of Science Communication and Policy Research. All rights reserved. -
Interface between the brain and computer to improve the e-commerce user security experience
Using brain-computer interface (BCI) technology for online shopping offers a state-of-the-art way to address the issue of enhancing user experience by creating more personalized and user-friendly shopping environments. This study explores how brain-computer interfaces (BCIs) can improve e-commerce platforms by better understanding customer preferences, emotional responses, and decision-making tendencies through the collection of real-time neural data. Brain-computer interfaces, or BCIs, use brain activity analysis to provide personalized recommendations, streamline navigation, and improve product displays-all of which contribute to a more enjoyable and rewarding shopping experience. This research examines the effects of BCI-enhanced e-commerce systems on user involvement, contentment, and purchase decisions. An extensive assessment of BCIs' effectiveness in improving the overall shopping experience is conducted through experimental analysis and customer feedback. The results show that adding BCIs to e-commerce systems can significantly boost user engagement and make. 2025, IGI Global Scientific Publishing. -
Interface improvement and multiscale assessment of recycled concrete aggregates with epoxy resin polymer
Recycled concrete aggregate (RCA) exhibits challenges like weak bonding, high porosity, and inferior strength compared to natural aggregates. This study evaluates the effect of epoxy resin polymer treatment on RCA on enhancing compressive and split tensile strengths in concrete, replacing natural aggregates with untreated RCA (UTRAC) and treated RCA (ERTAC) at 25%, 50%, 75%, and 100% levels. The tests were conducted at 3, 7, and 28 days. UTRAC showed reductions of up to 26.32% in compressive strength and 35.38% in tensile strength at 100% replacement; ERTAC outperformed control concrete (CC) with gains of up to 26.32% in compressive strength (at 25%) and 122.73% in tensile strength (at 100%), identifying 25% as the optimum replacement ratio. SEM and XRD analyses confirmed improved particle packing, reduced porosity, and stronger interfacial transition zones (ITZ) in ERTAC. The Author(s) 2026. -
INTERFACING PRIMAL RELIGION OF THE HAMAI (ZELIANGRONG), CHRISTIANITY, HERAKA, AND TINGKAO RAGWANG CHAPRIAK
This chapter explores the intertwinement between four religious traditions, namely (1) Characheng (primal religion of the Hamai) and its offshoots, (2) Heraka, (3) Tingkao Ragwang Chapriak (TRC), and (4) Christianity in contemporary Hamai (Zeliangrong) communities. The influence of the primal Hamai religion on Christianity is unquestionable, and at the same time, these two traditions hold sway over Heraka and TRC in varying degrees. The impacts of the interaction are at the levels of consciousness, belief systems, practices, and values. The chapter brings out the asymmetric encounter between reformed religious traditions (Heraka) of the Hamai and the proselytisation of Christianity in the Hamai communities that had led to the extinction of the primal religion of the former. Remarkably, Heraka and TRC are counter-proselytising movements against Christianity based on the primal belief system and synthesis of Christian and Hindu belief systems. For this purpose, the research employs comparative and dialogical approaches to explore and analyse the interconnection among the above religions. It argues that the current forms of Christianity, Heraka, and TRC in Hamai tribes are unique in themselves, and at the same time, they are also cyclically inspired by one another in the process of their encounters. 2025 selection and editorial matter, Maguni Charan Behera; individual chapters, the contributors. -
Intergenerational Transference of Collective Trauma in the Exilic Lives of Sri Lankan Tamil Refugees
The present study explores the intergenerational transference of collective trauma among the Sri Lankan Tamil Refugees (SLTR). Thirty-three in-depth interviews were conducted across first, second, and third generation SLTR living at the refugee camps in Tamil Nadu, India. The study found that the traumatic experiences and internal conflicts associated with exile among the first-generation participants (FGP) and second-generation participants (SGP) are primarily channeled through social customs and parenting styles. Refugee identity and correlated difficulties are constituted as collective trauma. The motive for resolving the fragmented self was unconscious replicated nightmares among the participants. Irrespective of generations, participants unconsciously tried to reintegrate their fragmented collective existence. The FGP and SGP passed the Sri Lankan Tamil culture onto their offspring, imposing expectations on the next generation to reclaim Tamil land and sustain cultural legacies. The study highlighted that helping behavior differs across generations, influenced by the encountered atrocities. Further extensive research on humanitarian rehabilitation policies is needed for their collective social integration. The Author(s), under exclusive licence to Springer Nature B.V. 2025. -
Internalized stigma among patients with common mental disorders in South India
Introduction: Common mental disorders (CMDs), include depressive disorders and anxiety disorders, which are highly prevalent. There exists a huge stigma around mental health, and this challenge becomes further magnified in CMDs, especially in LMICs like India. Despite this burden, there is limited scientific evidence on the internalized stigma in CMDs. To address this evidence gap, this study aims to describe internalized stigma and its correlates among patients with CMDs attending the Psychiatry Outpatient Department (OPD) of an academic teaching hospital in South India. Materials and methods: A structured socio-demographic and morbidity questionnaire, along with the Internalized Stigma of Mental Illness (ISMI) Scale, was administered to 119 patients aged 18 years or older who were diagnosed with CMDs according to ICD-10 criteria. Patients with severe mental disorders and psychosis, epilepsy, intellectual disability, organic mental disorders, and those requiring hospital admissions, were excluded from the study. Results: A mild to moderate level of internalized stigma was reported among patients with common mental disorders. Age and history of suicidal thought were significant predictors of internalized stigma. Conclusion: Youth and those who have a history of suicidal thoughts tend to experience greater internalized stigma. A multi-pronged approach is needed to address internalized stigma, which includes a combination of education and awareness programs, peer support programs, psychotherapy, and medication adherence. Addressing stigma can positively influence help-seeking behavior, treatment compliance, and outcomes, thereby improving quality of life. The Author(s) 2025. -
INTERNATIONAL CASES IN FORENSIC PSYCHOLOGY: Inside the Criminal Mind
This book provides an in-depth investigation of different psychological phenomena in forensic psychology through an analysis of key case studies in the field. There is a growing requirement for a comprehensive resource that provides practical examples of how forensic psychology models are applied in real-life situations. Filling this lacuna, International Cases in Forensic Psychology takes the reader through a series of prominent case studies that illustrate the intricate details of criminal investigations, judicial proceedings, and correctional settings. Drawing on a diverse range of examples from the US, UK, Belgium, Russia, Columbia, Germany, and India which include serial murder, financial deception, and maternal psychosis, Dr. K. Jayasankara Reddy applies psychological theories and methods to understand the intricacies of criminal conduct. These theories range from criminal profiling and behavioral analysis, to the psychology of deceit and the dynamics of influence. Overall, the book will enhance the readers ability to analyze the fundamental reasons behind criminal behaviour and develop more efficient approaches for rehabilitating offenders. International Cases in Forensic Psychology will be of great interest to students and professionals of forensic psychology, neuropsychology, criminal justice, and related fields. 2025 K. Jayasankara Reddy.