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Production of betalains in plant cell and organ cultures: a review
Betalains are nitrogen-containing natural pigments that are water soluble and they comprise of the red-violet betacyanin and the yellow betaxanthin which are abundant in plants such as red/yellow beet, amaranth, prickly pear, pitaya, and others. They are widely used as food coloring agents for many centuries. Betalains are used in pharmaceuticals, functional foods, and cosmeceuticals, since they have tremendous potential to scavenge free radicals and prevent diseases, such as hypertension, dyslipidemia, cancer, neurological disorders, and vascular stenosis. Betalains are proven to be toxicologically safe and have health benefits, they have been approved as food additives in the United States of America, and European countries. Although betalains can be found in natural resources, there are differences in their composition, amounts, and seasonality. For this reason, researchers have developed alternative methods of producing these valuable compounds using cell and organ culture techniques. In several plants, cell and organ cultures are established, and bioreactor technologies have been used to produce betalains on a wide scale. In this review, we discuss the varied biotechnological methods and approaches applied for the biosynthesis of betalains including metabolic engineering approaches. The Author(s), under exclusive licence to Springer Nature B.V. 2024. -
Anthocyanin Production from Plant Cell and Organ Cultures In Vitro
Anthocyanins are water-soluble pigments found in plants. They exist in various colors, including red, purple, and blue, and are utilized as natural colorants in the food and cosmetics industries. The pharmaceutical industry uses anthocyanins as therapeutic compounds because they have several medicinal qualities, including anti-obesity, anti-cancer, antidiabetic, neuroprotective, and cardioprotective effects. Anthocyanins are conventionally procured from colored fruits and vegetables and are utilized in the food, pharmaceutical, and cosmetic industries. However, the composition and concentration of anthocyanins from natural sources vary quantitively and qualitatively; therefore, plant cell and organ cultures have been explored for many decades to understand the production of these valuable compounds. A great deal of research has been carried out on plant cell cultures using varied methods, such as the selection of suitable cell lines, medium optimization, optimization culture conditions, precursor feeding, and elicitation for the production of anthocyanin pigments. In addition, metabolic engineering technologies have been applied for the hyperaccumulation of these compounds in varied plants, including tobacco and arabidopsis. In this review, we describe various strategies applied in plant cell and organ cultures for the production of anthocyanins. 2023 by the authors. -
Light as an elicitor for enhanced production of secondary metabolites in plant cell, tissue, and organ cultures
Currently, in vitro cell, tissue, and organ cultures are used to produce plant secondary metabolites that are used as natural coloring agents, nutraceuticals, and medications. Various strategies have been applied for the hyperaccumulation of biomass and bioactive secondary compounds in vitro. The elicitation of cultured cells and organs with biotic and abiotic elicitors is an excellent strategy that has yielded promising results. Among various abiotic elicitors, light parameters such as light quality, intensity, and photoperiod have evolved as biotechnological tools to elicit cultures. Of the various light sources tested, ultraviolet (UV) lights, particularly UV-B, red, blue, and a mixture of light emitted by fluorescent light or light-emitting diodes, have yielded outstanding results and boosted the accumulation of bioactive compounds in cultured cells and organs. The objective of the current study was to evaluate light as an elicitor source and summarize the advantages and limitations of various light sources as elicitors for the bioaccumulation of secondary metabolites in vitro. The mechanism of the elicitation of secondary metabolism by UV and spectral light is discussed in this review. The Author(s), under exclusive licence to Springer Nature B.V. 2024. -
Nanomaterials as novel elicitors of pharmacologically active plant specialized metabolites in cell and organ cultures: current status and future outlooks
Specialized plant metabolites, such as phenolics, terpenes, terpenoids, nitrogen-containing compounds, and sulfur-containing compounds, are commercially valuable owing to their wide array of applications in the medical, pharmacological, cosmetic, agriculture, and food industries. Procuring valuable specialized metabolites from wild or cultivated plants is desirable; however, the concentrations and quality of secondary compounds vary between samples. Therefore, plant cells and organ cultures have been selected as viable alternatives for producing specialized metabolites. Elicitation is a strategy used to enhance the accumulation of specialized compounds in cell and organ cultures. Different biotic substances, including signaling chemicals such as salicylic acid and methyl jasmonate, elements of plant cell walls (cellulose and pectin), polysaccharides from microbes (chitin and glucan), and abiotic substances such as inorganic salts, heavy metals, UV radiation, and high salinity, have been successfully tested and used as elicitors for the hyperaccumulation of bioactive substances in cell and organ cultures. Recently, metals, metal oxide nanoparticles, and carbon-based nanomaterials have been used as unique elicitors to boost the synthesis of bioactive compounds in cell and organ cultures. The applications and usage of nanoparticles as elicitors in plant cell and organ cultures are summarized in this review. The mechanism of elicitation, toxicity, benefits, and drawbacks of using nanoparticles in plant cell and organ cultures are discussed. Graphical abstract: (Figure presented.) The Author(s), under exclusive licence to Springer Nature B.V. 2023. -
Production of specialized metabolites in plant cell and organo-cultures: the role of gamma radiation in eliciting secondary metabolism
Purpose: To provide an updated summary of recent advances in the application of gamma irradiation to elicit secondary metabolism and for induction of mutations in plant cell and organ cultures for the production of industrially important specialized metabolites (SMs). Conclusions: Research on the application of gamma radiation with plants has contributed a lot to microbial decontamination of seeds, and the promotion of physiological processes such as seed germination, seedling vigor, plant growth, and development. Various studies have demonstrated the influence of gamma rays on the morphology, physiology, and biochemistry of plants. Recent research efforts have also shown that low-dose gamma (5100 Gy) irradiation can be utilized as an expedient solution to alleviate the deleterious effect of abiotic stresses and to obtain better yields of plants. Inducing mutagenesis using gamma irradiation has also evolved as a better option for inducing genetic variability in crops, vegetables, medicinal and ornamentals for their genetic improvement. Plant SMs are gaining increasing importance as pharmaceutical, therapeutic, cosmetic, and agricultural products. Plant cell, tissue, and organ cultures represent an attractive alternative to conventional methods of procuring useful SMs. Among the varied approaches the elicitor-induced in vitro culture techniques are considered an efficient tool for studying and improving the production of SMs. This review focuses on the utilization of low-dose gamma irradiation in the production of high-value SMs such as phenolics, terpenoids, and alkaloids. Furthermore, we present varied successful examples of gamma-ray-induced mutations in the production of SMs. Copyright 2024 Taylor & Francis Group LLC. -
Production of biomass and bioactive compounds from cell and organ cultures of ginseng, He-shou-wu, purple coneflower, and St. John's wort for the use in cosmetic industry
Plants and their products have been utilized as raw materials in the preparation of cosmetics for millennia. Currently, research is being done to find new plant materials that may be used as ingredients in cosmetic preparations, including body sprays, shampoos, conditioners, hair dyes/sprays, and other cosmetics. The plants that are used in the preparation of cosmetic products are usually procured from nature, however, the quality and quantity of bioactive ingredients present in the biomass vary based on the species, environment, and geographical locations from where the material has been procured. In addition, procurement of plant material from natural resources may lead to a shortage of material and even endanger the status of rare plants in the natural environment. Therefore, there is increased interest in the use of plant cell, tissue, and organ cultures (PCTOC) for the production of raw materials and bioactive specialized metabolites. There is also scope for increasing the accumulation of biomass and bioactive compounds in PCTOC by adopting various strategies such as optimization of culture medium, culture environment, elicitation, and other bioprocess methods. Furthermore, PCTOC-produced raw materials are free from contaminants, pesticides, and heavy metals and an important benefit of producing biomass in vitro is that it is easily accepted by regulatory authorities and consumers. In the current review, we describe the bioactive compounds of ginseng, purple coneflower, He-shou-wu, and St. John's wort which have cosmetological importance. Additionally, we elucidate the PCTOC method adopted for the production of biomass and bioactive compounds in these plants. 2023 SAAB -
Bioreactor configurations for adventitious root culture: recent advances toward the commercial production of specialized metabolites
In vitro plant cell and organ cultures are appealing alternatives to traditional methods of producing valuable specialized metabolites for use as: pharmaceuticals, food additives, cosmetics, perfumes, and agricultural chemicals. Cell cultures have been adopted for the production of specialized metabolites in certain plants. However, in certain other systems, adventitious roots are superior to cell suspension cultures as they are organized structures that accumulate high levels of specialized metabolites. The cultivation of adventitious roots has been investigated in various bioreactor systems, including: mechanically agitated, pneumatically agitated, and modified bioreactors. The main relevance and importance of this work are to develop a long-lasting industrial biotechnological technology as well as to improve the synthesis of these metabolites from the plant in vitro systems. These challenges are exacerbated by: the peculiarities of plant cell metabolism, the complexity of specialized metabolite pathways, the proper selection of bioreactor systems, and bioprocess optimization. This reviews major objective is to analyze several bioreactor types for the development of adventitious roots, as well as the advantages and disadvantages of each type of bioreactor, and to describe the strategies used to increase the synthesis of specialized metabolites. This review also emphasizes current advancements in the field, and successful instances of scaled-up cultures and the generation of specialized metabolites for commercial purposes are also covered. 2023 Informa UK Limited, trading as Taylor & Francis Group. -
Bioreactor systems for micropropagation of plants: present scenario and future prospects
Plant micropropagation has been adapted in the fields of agriculture, horticulture, forestry, and other related fields for large-scale production of elite plants. The use of liquid media and adoption of bioreactors have escalated the production of healthy plants. Several liquid-phase, gas-phase, temporary immersion, and other modified bioreactors have been used for plant propagation. The design, principle, operational mode, merits, and demerits of various bioreactors used for the regeneration of propagules, such as bulblets, cormlets, rhizomes, microtubers, shoots (subsequent rooting), and somatic embryos, are discussed here. In addition, various parameters that affect plant regeneration are discussed with suitable examples. Copyright 2023 Murthy, Joseph, Paek and Park. -
Anthraquinone Production from Cell and Organ Cultures of Rubia Species: An Overview
The Rubia genus includes major groups of medicinal plants such as Rubia cordifolia, Rubia tinctorum, and Rubia akane. They contain anthraquinones (AQs), particularly alizarin and purpurin, which have pharmacological effects that are anti-inflammatory, antioxidant, anticancer, hemostatic, antibacterial, and more. Alizarin and purpurin have been utilized as natural dyes for cotton, silk, and wool fabrics since the dawn of time. These substances have been used in the cosmetics and food industries to color products. The amount of AQs in different Rubia species is minimal. In order to produce these compounds, researchers have established cell and organ cultures. Investigations have been conducted into numerous chemical and physical parameters that affect the biomass and accumulation of secondary metabolites in a cell, callus, hairy root, and adventitious root suspension cultures. This article offers numerous techniques and approaches used to produce biomass and secondary metabolites from the Rubia species. Additionally, it has been emphasized that cells can be grown in bioreactor cultures to produce AQs. 2022 by the authors. -
Progress in psycho-oncology with special reference to developing countries
Purpose of reviewPsycho-oncology has completed 25 years. There is growing recognition of the psychosocial needs of persons living with cancer and the role of sociocultural factors in addressing the needs. This review addresses the research in developing countries relating to distress associated with living with cancer and psychosocial care.Recent findingsThere is growing recognition of the emotional needs, understanding of the sociocultural aspects of the emotional responses of persons, caregivers, role of resilience and posttraumatic growth and spirituality in cancer care. Psychosocial aspects of cancer are largely influenced by social, economic, cultural, religious and health systems. A number of innovative approaches to care like use of yoga, financial and material support and involvement of caregivers have been implemented. A positive development is the increasing professional attention to document and develop innovative care programmes.SummaryA significant proportion of the general population are living with cancer. There are significant psychosocial needs largely influenced by social, economic, cultural, religious aspects of the communities. There are a wide range of interventions from self-care to professional care to address the needs. In developing countries, there is need for longitudinal studies of psycho-social experiences, develop interventions that are culturally appropriate, along with enhanced use of information technology along with evaluation of interventions. 2019 Wolters Kluwer Health, Inc. All rights reserved. -
Biopolymers as promising vehicles for drug delivery to the brain
The brain is a privileged organ, tightly guarded by a network of endothelial cells, pericytes, and glial cells called the blood brain barrier. This barrier facilitates tight regulation of the transport of molecules, ions, and cells from the blood to the brain. While this feature ensures protection to the brain, it also presents a challenge for drug delivery for brain diseases. It is, therefore, crucial to identify molecules and/or vehicles that carry drugs, cross the blood brain barrier, and reach targets within the central nervous system. Biopolymers are large polymeric molecules obtained from biological sources. In comparison with synthetic polymers, biopolymers are structurally more complex and their 3D architecture makes them biologically active. Researchers are therefore investigating biopolymers as safe and efficient carriers of brain-targeted therapeutic agents. In this article, we bring together various approaches toward achieving this objective with a note on the prospects for biopolymer-based neurotherapeutic/neurorestorative/neuroprotective interventions. Finally, as a representative paradigm, we discuss the potential use of nanocarrier biopolymers in targeting protein aggregation diseases. 2023 Informa UK Limited, trading as Taylor & Francis Group. -
Production, Delivery, and Regulatory Aspects for Application of Plant-Based Anti-microbial Peptides: a Comprehensive Review
Antimicrobial peptides (AMPs) are small, positively charged biomolecules produced by various organisms such as animals, microbes, and plants. These AMPs play a significant role in defense mechanisms and protect from adverse conditions. The emerging problem of drug resistance in microbes poses a global health challenge in treating diseases. This plant-based antimicrobial peptide is a promising candidate for fighting against drug-resistant microbes. The PAMPs process specific key properties, proving their efficacy as antimicrobial agents against a broad spectrum of microbes such as Gram-positive, Gram-negative, and fungi. Extensive research on PAMPs has explored their potential as plant growth regulators and therapeutic agents. Their diverse mode of action on microbes encouraged their application in food industries. ThePAMPs are isolated and purified from various plant species organs such as roots, shoots, leaves, flowers, and seeds. These are bioactive molecules with significant stability, and low toxicity has encouraged their application as food additives. Furthermore, to meet the consumer demand, mass production of AMPs was possible with recombinant DNA technology. The advanced and nanotechnology-based delivery system has significantly improved the efficacy and bioavailability of PAMPs as food preservatives for improved shelf-life and prevent spoilage of food products. ThePAMPs are of green origin and can be used as natural bio preservatives that do not alter the sensory properties of food and are harmless to consumers. Plants being the rich resource of AMPs to support their quick identification, and retrieval for commercial applications there is a need to integrate the omics approach with databases. TheAMPs are small, positively charged biomolecules produced by various organisms such as animals, microbes, and plants. These AMPs play a significant role in defense mechanisms and protect from adverse conditions. The emerging problem of drug resistance in microbes poses a global health challenge in treating diseases. This plant-based antimicrobial peptide is a promising candidate for fighting against drug-resistant microbes. The PAMPs process specific key properties, proving their efficacy as antimicrobial agents against a broad spectrum of microbes such as Gram-positive, Gram-negative, and fungi. Extensive research on PAMPs has explored their potential as plant growth regulators and therapeutic agents. Their diverse mode of action on microbes encouraged their application in food industries. ThePAMPs are isolated and purified from various plant species organs such as roots, shoots, leaves, flowers, and seeds. These are bioactive molecules with significant stability, and low toxicity has encouraged their application as food additives. Furthermore, to meet the consumer demand, mass production of AMPs was possible with recombinant DNA technology. The advanced and nanotechnology-based delivery system has significantly improved the efficacy and bioavailability of PAMPs as food preservatives for improved shelf-life and prevent spoilage of food products. ThePAMPs are of green origin and can be used as natural bio preservatives that do not alter the sensory properties of food and are harmless to consumers. Plants being the rich resource of AMPs to support their quick identification, and retrieval for commercial applications there is a need to integrate the omics approach with databases. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. -
Exploring ocean pH dynamics via a mathematical modeling with the Caputo fractional derivative
Global warming is a complex problem with far-reaching global implications. One of its notable repercussions is the escalation of CO2 levels in the atmosphere, resulting in the phenomenon known as Ocean Acidification (OA). In this research, we have established a correlation between four key factors: marine species, human population, CO2 levels, and ocean pH. By formulating a Caputo fractional differential equation, we investigated the dynamics of these variables to evaluate the significance of this climatic phenomenon. The model analysis reveals that the rise in anthropogenic CO2 emissions causes a reduction in the oceans pH level and increases OA.This process, in turn, decreases the oceans ability to absorb CO2, making it less effective in mitigating climate change. In this study, it was demonstrated that elevated levels of CO2 result in a reduction in pH levels, which in turn causes a decrease in the population of marine species that play a critical role in numerous economic sectors such as tourism, aquaculture, and fisheries. Moreover, we conducted a comprehensive analysis of the influence exerted by the intrinsic growth rate of the human population. We examined various theoretical aspects, including the assessment of existence and uniqueness. Numerical simulations are carried out to illustrate the effect of key parameters on the dynamics of the system using the generalized AdamsBashforthMoulton method. The Author(s) 2024. -
A Scoping Review on the Factors Affecting the Adoption of Robo-advisors for Financial Decision-Making
Robo-advisors have recently gained popularity as an algorithm-based method of simplifying financial management. The present study explores the factors that lead many potential consumers to use Robo-advisors in financial decisions. Adopting a scoping review approach formulated by Arksey and O'Malley, the study examines the factors affecting the acceptance and usage of financial Robo-advisors in different parts of the world. The results suggest that performance expectancy, effort expectancy, trust in technology, financial knowledge, investing experience, cost-effectiveness, facilitating conditions, and intrinsic motivation are positively related to adopting Robo-advisors. On the contrary, anxiety, risk perception, investor age, data security, and behavioral biases negatively influence the investor attitude toward Robo-advisors. This creates a barrier to the diffusion of financial Robo-advisors among the investors. The study concludes by providing recommendations to service providers, policymakers, and marketers for the speedy distribution and acceptance of algorithms for the public's financial decision-making. The study identifies gaps in the existing literature and suggests areas for future research for aspiring academics. 2024 University of Pardubice. All rights reserved. -
Impact of nanoparticles on immune cells and their potential applications in cancer immunotherapy
Nanoparticles represent a heterogeneous collection of materials, whether natural or synthetic, with dimensions aligning in the nanoscale. Because of their intense manifestation with the immune system, they can be harvested for numerous bio-medical and biotechnological advancements mainly in cancer treatment. This review article aims to scrutinize various types of nanoparticles that interact differently with immune cells like macrophages, dendritic cells, T lymphocytes, and natural killer (NK) cells. It also underscores the importance of knowing how nanoparticles influence immune cell functions, such as the production of cytokines and the presentation of antigens which are crucial for effective cancer immunotherapy. Hence overviews of bio-molecular mechanisms are provided. Nanoparticles can improve antigen presentation, boost T-cell responses, and overcome the immunosuppressive tumor environment. The regulatory mechanisms, signaling pathways, and nanoparticle characteristics are also presented for a comprehensive understanding. We review the nanotechnology platform options and challenges in nanoparticles-based immunotherapy, from an immunotherapy perspective including precise targeting, immune modulation, and potential toxicity, as well as personalized approaches based on individual patient and tumor characteristics. The development of emerging multifunctional nanoparticles and theranostic nanoparticles will provide new solutions for the precision and efficiency of cancer therapies in next-generation practice. Copyright 2024 The Authors. -
Learning through Play: Gamification of Learning A Systematic Review of Studies on Gamified Learning
According to Gartner's Hype Cycle, gamification is poised for large-scale adoption in the coming years. The construct of gamification has received considerable interest, especially in the context of learning. Over the past five years, research in the area has grown. The current study looks at consolidating the conducted research and attempts to provide a snapshot of the work carried out in the last five years. The chosen studies have explored the role of gamification in learning activities and have attempted to provide empirical evidence to support gamified learning. The purpose of the study is to review existing literature, in terms of the outcomes, outcome variables, context of the study, and research methodology used. This would not only add to the knowledge in the field but would also guide future research. Additionally, practitioners would benefit from a consolidated view of five years of research into the practice of gamification. 2022 University of Tehran, Faculty of Management, Sridevi Nair and Jain Mathew -
Evaluation of a gamified learning experience: Analysis of factors that impact the effectiveness of a gamified experience; [Avaliao de uma expericia de aprendizagem gamificada: Anise dos fatores que afetam a eficia de uma expericia gamificada]
Gamification has gone through a faddish cycle. It first gained prominence around 2012 and was quickly abandoned, as practitioners did not achieve the outcomes they expected. According to Gartner's Hype Cycle, Gamification is at a point at which one might expect wide scale adoption. However, if history is not to repeat itself and results are to be achieved as theoretically predicted, a deeper understanding of the concept is essential. In the current study, the researchers attempt to evaluate a gamified learning experience. The participants were students of a Master in Business Administration course. The students were asked to participate in a gamified module and relevant data was collected, before and after the intervention. Based on a review of literature, the researchers identified the exogenous variables of Valence, Attitude towards use of Technology and Experience with Technology. The endogenous variables identified included Reaction and Learning. The findings of the study suggest that the gamified module resulted in increase in knowledge and that Attitude, Experience and Valence significantly predicted the Learner's reaction to the experience. The findings of the study provide support to key theories in the area of gamification and insights for practitioners, on the factors to be considered before using a gamifiedlearning intervention. 2021 UNIVERSIDADE FEEVALE All rights reserved. -
Relationship between leadership support and operational excellence in health care sector: A study of Indian health care managers; [Relaci entre respaldo al liderazgo y excelencia operativa en el sector sanitario: estudio de los gestores de un centro sanitario en India]
Background and objective: Leadership communicates purpose and innovative ways to thrive for performance. Leadership support influences and impacts operational excellence in the health sector as a patient-centered operation, with effective management, excellence framework, challenges and constraints, teamwork and value stream mapping. It is hypothesized that: (1) perceived leadership support will positively correlate with perceived operational excellence (Patient-centered Operations, Effective Resource Management, Excellence framework, Eliminating Challenges or Constraints, Team Work, Value Stream Mapping) and (2) the correlation would be highest with Patient-centered Operations. The aim of this study was to examine the relationship between leadership support and operational excellence in the health care sector among a selected group of healthcare managers. Materials and method: A correlation study between leadership support and operational excellence was designed for a group of health care managers (n = 80) from eight hospitals in Kerala, South India. The selection of executives was from NABH accredited hospitals from districts with a minimum of four NABH accredited hospital. A survey was sent to a selected study sample. The respondents were cooperative and provided responses on perceived leadership support for operational excellence. Results: Factors of leadership support correlated to operational excellence. Conclusion: In the health care sector, leadership support for patient-centered operations helps achieve operational excellence. 2020 -
The organizational pedestal of quality of care climate in health care excellence; [Grundpfeiler einer qualitsorientierten Versorgungskultur: Gesundheitsversorgung in Indien]
Background: Health care in private healthcare organizations is a balancing act between business excellence and quality outcomes in practice. This complex activity establishes the existence of quality of care climate so as the pedestal of quality of care decisions bring health care excellence. In healthcare, Quality of care is not linear but multi-dimensional, with myriad challenges. Purpose: The aim of the study was to establish the organizational pedestal for quality of care and predominant quality of care dimension. Method: This study was approved by the IRB of our Institution. This study empirically tested the quality of care climate types in NABH accredited and non-accredited hospitals using quantitative method with a sample of 410 healthcare managers from accredited and non-accredited hospitals in South India. Results: The results indicate that among the dimensions of quality of care climate, competitive advantage was perceived the lowest with a mean rating of 73.14 among the rest. Value-Stream was perceived as the highest quality of care climate with a mean of 83.12. The results indicate that patient centered value-stream is the predominant dimension of quality of care climate as perceived by the managers and value stream is the predominated determinant of patient centered decisions. Conclusions: The results designate a promising support for patient centered quality of care approach for health care excellence with a balance on value stream mapping. 2021 -
Synthesis, properties, and state-of-the-art advances in surface tuning of borophene for emerging applications
Being composed of boron atoms that can be maneuvered to orchestrate low planar hexagonal structures, this two-dimensional material carefully exhibits versatility and has conventional covalent bonds between each atom. Borophene has recently proliferated the scientific research community by storm, trailblazing industries from fine chemicals, electrical equipment manufacturing, and biomedical innovation up to sustainable energy. Here, we provide streamlined information and particulars about the recent advances in the evolution of borophene since its inception and the essence of its electrocatalytic applications. We first introduce the sophisticatedly cultivated progress in borophene's structural, mechanical, optical, and electrical properties and further discuss its variegated polymorphism. Subsequently, we also delve into several capable synthesis techniques and recently concocted surface tuning and doping methods. Finally, we analyze the advancing state-of-the-art applications of this two-dimensional nanomaterial under investigation, ranging from bioimaging, energy storage, electrode reduction, and electrochemical sensing. Further, we have broadly discussed the future insights and challenges that borophene brings. 2024