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Evaluation of therapeutic potentials of selected phytochemicals against Nipah virus, a multi-dimensional in silico study
The current study attempted to evaluate the potential of fifty-three (53) natural compounds as Nipah virus attachment glycoprotein (NiV G) inhibitors through in silico molecular docking study. Pharmacophore alignment of the four(4) selected compounds (Naringin, Mulberrofuran B, Rutin and Quercetin 3-galactoside) through Principal Component Analysis (PCA) revealed that common pharmacophores, namely four H bond acceptors, one H bond donor and two aromatic groups were responsible for the residual interaction with the target protein. Out of these four compounds, Naringin was found to have the highest inhibitory potential ( 9.19kcalmol?1) against the target protein NiV G, when compared to the control drug, Ribavirin ( 6.95kcalmol?1). The molecular dynamic simulation revealed that Naringin could make a stable complex with the target protein in the near-native physiological condition. Finally, MM-PBSA (Molecular Mechanics-PoissonBoltzmann Solvent-Accessible Surface Area) analysis in agreement with our molecular docking result, showed that Naringin ( 218.664kJmol?1) could strongly bind with the target protein NiV G than the control drug Ribavirin ( 83.812kJmol?1). 2023, King Abdulaziz City for Science and Technology. -
Evaluation of web applications based on UX parameters
The objective of evaluating User Experience (UX) in this era of technology is to enhance the user satisfaction. Earlier applications were built with the aim of reducing the work of users. But with the evolution of the technology, the emergence of new gadgets and new trends in the information technology, the applications had to be more user-centric. The primary objective of this research is to evaluate the user experience of web applications based on different UX parameters using different techniques and given a rating. Each of these ratings are combined to determine the overall rating of UX for the web application. Also, the secondary objective of this research is to provide suggestions or recommendations based on the ratings to improve the UX of the web applications. An experimental study was conducted and the results show a significant improvement. Areas of further enhancements have also been identified and presented. 2019 Institute of Advanced Engineering and Science. -
Evaluation of Wound Healing Effect of Curcumin Loaded OPL Carbon Nanospheres Embedded Chitosan Membranes
Biowaste-derived carbon biomaterial scaffolds are being used for wound healing and are the focus of interest. Carbon nanospheres derived from oil palm leaves without any catalysts via pyrolysis were loaded with a traditional drug curcumin. The wound healing scaffolds were fabricated on the PP non-woven fabric support using chitosan as the biopolymer matrix. Prepared carbon nanospheres and the scaffolds were characterized using ATR-IR and FESEM techniques. The wettability of scaffolds was examined to ensure the feasible moisture absorption ability, in vitro drug release profile and in vitro antibacterial activity against two strains of bacteria. The in vivo wound healing feature of scaffolds was studied by excision wound model for MRSA infected wound. Measured wound contraction percentage and the bacterial count on wounds at regular time intervals proved that, the scaffold dressed with chitosan and curcumin loaded carbon nanospheres showed an efficient reconstruction of skin through histopathological investigations. 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. -
Evaluation on effect of alkaline activator on compaction properties of red mud stabilised by ground granulated blast slag
Any industrial waste has a potential to be used as a civil engineering material with an effective and appropriate waste management system. Like many industrial wastes, red mud (RM) and Ground granulated blast slag (GGBS) are some of the industrial wastes produced from aluminium and steel industries respectively. Utilization of only waste materials will not be effective without a suitable stabilizer, which forced to use an alkaline activator to satisfy the needs of a building materials. This paper evaluates measurements to assess the effect of alkaline activator on the compaction properties of GGBS stabilized RM. Different ratios of NaOH to Na2SiO3 was used as an alkaline activator with 10, 20 and 30 percentage replacement of GGBS to RM and measured the compaction properties by using a mini compaction apparatus. Upon conducting standard and modified proctor compaction tests for various combinations of RM and GGBS, the compaction curves depicted that huge variation in maximum dry density and optimum moisture content with the change of GGBS percentage and different ratios of NaOH to Na2SiO3 are measured and analysed. Further the influence of compaction energy on the density characteristics of these trails were assessed for better understanding. Copyright: This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. -
Even Numbered Saturdays are More Joyful for Bank Employees in India - A Critical Analysis
Journal of Exclusive Management Sciences, Vol. 5, Issue 4, ISSN No. 2277-5684 -
Evidence and Predictors of Resilience among Young Adults Exposed to Traumatic Events of the Armed Conflict in Kashmir
No study to date exists regarding resilience in the context of armed conflict in Kashmir, India. Therefore, this study intended to understand the factors that predict resilience among young adults affected by the violence of the protracted conflict in Kashmir. The data were collected from 656 students, who experienced stress, related to the conflict. Findings showed that more than a quarter of the respondents (35.8%) were exposed, from 7 to 10, less than a quarter (16.6%) of participants reported 26, and almost half of the respondents (47.6%) were exposed to 11 or more stressful events related to the conflict in Kashmir. Multiple hierarchical regression analysis was used to examine the role of conflict exposure, social support, and demographic variables in predicting resilience. The results of the final regression model revealed that exposure to armed conflict, social support, level of education, monthly family income and gender, emerged as significant predictors of resilience. The study recommends the formulation of programs to sensitize people living in the areas affected by the armed conflicts, regarding the importance of social support and resilience, to help them withstand various adverse life experiences. 2021 Taylor & Francis Group, LLC. -
Evidence of microRNAs origination from chloroplast genome and their role in regulating Photosystem II protein N (psbN) mRNA
The microRNAs are endogenous, regulating gene expression either at the DNA or RNA level. Despite the availability of extensive studies on microRNA generation in plants, reports on their abundance, biogenesis, and consequent gene regulation in plant organelles remain naVve. Building on previous studies involving pre-miRNA sequencing in Abelmoschus esculentus, we demonstrated that three putative microRNAs were raised from the chloroplast genome. In the current study, we have characterized the genesis of these three microRNAs through a combination of bioinformatics and experimental approaches. The gene sequence for a miRNA, designated as AecpmiRNA1 (A. esculentus chloroplast miRNA), is potentially located in both the genomic DNA, i.e., nuclear and chloroplast genome. In contrast, the gene sequences for the other two miRNAs (AecpmiRNA2 and AecpmiRNA3) are exclusively present in the chloroplast genome. Target prediction revealed many potential mRNAs as targets for AecpmiRNAs. Further analysis using 5N RACE-PCR determined the AecpmiRNA3 binding and cleavage site at the photosystem II protein N (psbN). These results indicate that AecpmiRNAs are generated from the chloroplast genome, possessing the potential to regulate mRNAs arising from chloroplast gene(s). On the other side, the possibility of nuclear genome-derived mRNA regulation by AecpmiRNAs cannot be ruled out. 2024, Termedia Publishing House Ltd.. All rights reserved. -
Evolution of primordial dark matter planets in the early Universe
In a recent paper we had discussed possibility of DM at high redshifts forming primordial planets composed entirely of DM to be one of the reasons for not detecting DM (as the flux of ambient DM particles would be consequently reduced). In this paper we discuss the evolution of these DM objects as the Universe expands. As Universe expands there will be accretion of DM, helium and hydrogen layers (discussed in detail) on these objects. As they accumulate more and more mass, the layers get heated up leading to nuclear reactions which burn H and He when a critical thickness is reached. In the case of heavier masses of these DM objects, matter can be ejected explosively. It is found that the time scale of ejection is smaller than those from other compact objects like neutron stars (that lead to x-ray bursts). These flashes of energy could be a possible observational signature for these dense DM objects. 2021 COSPAR -
Evolutionary multiple instance boosting framework for weakly supervised learning
Multiple instance boosting (MILBoost) is a framework which uses multiple instance learning (MIL) with boosting technique to solve the problems regarding weakly labeled inexact data. This paper proposes an enhanced multiple boosting frameworkevolutionary MILBoost (EMILBoost) which utilizes differential evolution (DE) to optimize the combination of weak classifier or weak estimator weights in the framework. A standard MIL dataset MUSK and a binary classification dataset Hastie_10_2 are used to evaluate the results. Results are presented in terms of bag and instance classification error and also confusion matrix of test data. 2021, The Author(s). -
Evolving corporate sustainable development: a case study of Mysore Paper Mills Limited
In 1987, the World Commission on Economic Development (WCED) popularized the term sustainable development in its well-cited report, Our Common Future. According to this report, sustainable development is defined as the development that meets the needs of the present without compromising the ability of future generations to meet their own needs. The WCED asserted that sustainable development required simultaneous adoption of environmental, economical, and equity principles. Bansal (Strategic Management Journal, 26(3), 197218, 2005) has conducted a study of Canadian firms in the oil and gas, mining, and forestry industries from 1986 to 1995. The study found that both resources based and institutional factors influence corporate sustainable development. This paper studied the corporate sustainable development of Mysore Paper Mills Ltd. from 1995 to 2011 using the same model. The study found that independent variables with significant impact on environmental integrity and overall sustainability were fines, penalties, court cases (total) involved by the company, and log of total assets. On economic prosperity, the independent variable with significant impact is log of total assets. For social equity, the independent variable with significant impact is foreign sales as percentage of total sales, number of fines/penalties/court cases (total), number of fines/penalties/court cases (environmental), log(total assets), and return on equity. 2013, Springer Science+Business Media Dordrecht. -
Exact and statistical computations of radiated flow of nano and Casson fluids under heat and mass flux conditions
The statistical and exact analysis of the unsteady radiative flow of Nano and Casson fluids past a vertical plate with Dufour effect is carried out. The heat transport phenomenon is studied under uniform heat flux (UHF) and uniform wall temperature (UWT) conditions. The exact solution to the problem is found using the Laplace transform method (LTM). The effects of various parameters on velocity, temperature and concentration profiles are examined via graphs. The heat transfer rate and skin friction are analyzed through statistical tools like probable error and regression. The Dufour effect enhances the velocity and temperature profiles. It is also observed that the velocity profile is slightly greater in the case of UWT than the UHF case for both nanofluid and Casson fluid. From the regression analysis, it is established that the Dufour number and nanoparticle volume fraction have a negative impact whereas the radiative heat parameter has a positive impact on the rate of heat transfer. 2019 Society for Computational Design and Engineering -
Exact solution of non-coaxial rotating and non-linear convective flow of cual2 o3 h2 o hybrid nanofluids over an infinite vertical plate subjected to heat source and radiative heat
This paper investigates the non-linear convective flow due to non-coaxial rotation of vertical planar plate by utilizing three different liquids namely H2 O (water), Al2 O3 H2 O (nanofluid) and CuAl2 O3 H2 O (hybrid nanofluid). The impacts of Rosselands radiative heat and internal heat generation are also included in this study. The non-coaxial rotation of the plate crafts sine or cosine oscillations in its plane and the liquid at infinity. The density-temperature relation is studied which is nonlinear and causes a nonlinear convective heat transfer. The dynamic viscosity, thermal conductivity, density and specific heat of hybrid-nanofluids are assumed to vary with the volume fraction. These thermophysical properties of hybrid and nanofluids are determined by phenomenological laws and mixture theory. The simulation of the flow was carried out using the appropriate values of the empirical shape factor for five different particle shapes (i.e., sphere, hexahedron, tetrahedron, column and lamina). The LTM (Laplace Transform Technique) is employed to find the exact solutions. The flow, skin friction and thermal features are scrutinized with the discrepancy of governing parameters. The effective fluid properties and the Nusselt number are also calculated for sixteen different hybrid-nano-liquids. 2019 by American Scientific Publishers All rights reserved. -
Exact solutions for unsteady mixed convection flow of nanoliquid with exponential heat source: Bruggeman and batchelor nanofluid model
The objective of this paper is to explore the influence of exponential heat source and radiative heat on the thermal and mass transport of nanofluid flow over a vertical sheet. Unlike traditional nanofluid models, the Bruggeman and Batchelor models are utilized to estimate the thermal conductivity and dynamic viscosity of the nanofluid. The water-based copper nanoliquid is considered. Mass flux boundary condition is employed. The governed differential problem is solved by Laplace Transform Method (LTM) for exact solutions. The impact of dimensionless sundry parameters on flow distributions is analyzed and bestowed graphically. The rate of heat transfer has been assessed. Also, the slope of the linear regression line through data points is determined in order to quantify increase/decrease in the Nusselt number. Results exhibited that all the flow fields (velocity and temperature) are increasing functions of thermal and solutal Grashof numbers. Also, the presence of exponential heat source highly affects the heat transfer performance. 2018 by American Scientific Publishers All rights reserved. -
Examination of sustainability goals: A comparative study of U.S. and Indian firms
Considerable attention has focused on tactics firms use when building their sustainability platforms. Less is known, however, about how sustainability goal setting varies globally, especially in developing economies. Accordingly, we examined sustainability goals of 21 of the 50 largest Indian firms and compared them with similar data from a published study that examined 22 of the 50 largest U.S. firms. In total, 679 sustainability goals were analyzed using a triple bottom line framework. We found U.S. firms set more sustainability goals than Indian firms. Firms from both samples set similar numbers of people goals but U.S. firms set more diversity goals. Indian firms were more inclined to set economic and community development goals. We also detected differences across the samples in planet goals associated with emissions and water. Especially significant, Indian firms were much more likely than U.S. firms to specify profit goals. Implications for research and practice are discussed. 2019 Cambridge University Press and Australian and New Zealand Academy of Management. -
Examination of thermal and velocity slip effects on the flow of blood suspended with aluminum alloys over a bi-directional stretching sheet: the ternary nanofluid model
The flow of a ternary nanofluid through a bi-directionally distending sheet has been analyzed by employing the Casson model. The ternary nanofluid is formed by suspending the aluminum alloys namely (Formula presented.) and (Formula presented.) along with the oxide (Formula presented.) into blood. The nanoparticles that are suspended in the base fluid are assumed to be in the shape of a blade so that the maximum surface of the nanoparticle will be intact with the base fluid and thus will absorb more heat from the surface. Also, the shape of the nanoparticle helps in faster movement within the nanofluid. The flow is further subjected to velocity and thermal slips. With these assumptions, the mathematical model is framed with the help of partial differential equations considering thermal radiation and heat source/sink to achieve realistic results. These equations are further transformed into non-linear differential equations that are solved using the (Formula presented.) technique. The results of this study are interpreted graphically for various parameters concerning fluid flow. It is observed that the fluid flow velocity is ebbed considerably with the increase in Casson parameter and the slips at the boundary have enhanced the corresponding fluid profiles. 2022 Informa UK Limited, trading as Taylor & Francis Group. -
Examining growth inequality nexus in post-reform Odisha: A sectoral decomposition analysis /
Journal of Development Policy And Practice, Vol.4, Issue 1, pp.12-34 -
Examining psychometric properties of the Interpersonal Needs Questionnaire among college students in India
Background: With the second-highest population in the world, suicide-related deaths in India are high, and adults under 30 are particularly at an increased risk. However, empirical examinations of factors contributing to suicide in India and assessments of reliability and validity of self-report measures assessing these constructs are rare. Aims: The present study examined the psychometric properties of the Interpersonal Needs Questionnaire (INQ). Materials & Methods: Undergraduate students in India (N=432) completed the INQ and questionnaires assessing suicidal ideation, depression, fearlessness about death, and pain tolerance. Results: Confirmatory factor analyses of the 15-item INQ indicated that after removing three items assessing perceived burdensomeness, the two-factor structure of INQ demonstrated acceptable fit with good internal consistency for each of the subscales (?=.84.90). In line with the interpersonal-psychological theory of suicidal behavior (IPTS), thwarted belongingness and perceived burdensomeness interacted to predict suicidal ideation. Additionally, these constructs were positively associated with suicidal ideation and depression, and weakly correlated with fearlessness about death and pain tolerance. Discussion: Results support the relevance of the IPTS for understanding suicidal ideation among college students in India. Conclusion: The results suggest that modified INQ demonstrates strong internal consistency, as well as good construct, criterion, and discriminant validity among Indian college students. 2021 The American Association of Suicidology. -
Examining scientific contribution of International Journal of Productivity and Quality Management (20062019) a bibliometric study
International Journal of Productivity and Quality Management (IJPQM) is a journal of global reputation that publishes original and peer-reviewed research in the business management and accounting purview. The journal reached its 17th year of publishing in 2022. This study provides an inclusive synopsis of 720 publications using bibliometric data analysis techniques. The study emphasises the contribution of IJPQM to the academic fraternity through the analysis of publishing developments, authorship analysis, influential contributors, prominent studies published in IJPQM, nature and industry of studies. Analysis of the journal through SCImago indicators is also presented in the study. 2024 Inderscience Enterprises Ltd. -
Examining the consumption of oil on total factor productivity and CO2 emissions: an analysis of highly oil-consuming countries
Purpose: This study aims to examine the impact of oil consumption on carbon dioxide (CO2) emissions and total factor productivity (TFP) in highly oil-consuming countries of the world from 1995 to 2019. Design/methodology/approach: For this purpose, fully modified ordinary least squares (FMOLS) and dynamic ordinary least squares (DOLS) are applied. Findings: FMOLS and DOLS models reveal that oil consumption, human capital, population, trade openness and nonrenewable energy have a significant positive effect on CO2 emissions. While information and communication technology (ICT), as proxied by mobile and natural resources, has a significant negative effect on CO2 emissions. In the case of TFP, oil consumption, ICT and natural resources have a significant positive effect on the TFP. On the other hand, trade openness, population, human capital and nonrenewable energy have a significant negative effect on TFP. The results of this study can help to provide policy recommendations to reduce CO2 emissions in studied highly oil-consuming countries of the world. Originality/value: Due to the threat to sustainable development, climate change has become a major topic for debate around the world. The influence of oil consumption on CO2 emission and TFP is less known in the available literature. Another significance of this study is that many researchers considered aggregate energy consumption to study this relationship, but the authors have studied the effect of energy consumption, particularly from oil in the top oil-consuming countries, which is a significant shortcoming of the present research. 2023, Emerald Publishing Limited. -
Examining the effect of explicit instruction on vocabulary learning and on receptive-productive gap: An experimental study
This research study emphasized the importance of explicit instruction and repeated exposure to the target vocabulary for effective reception and production of new words among the second language learners of English. The purpose of the study was to examine the efficacy of the researcher- created supplementary for the prescribed set of vocabulary in the English language textbook. The study aimed to find out the amount of influence the explicit instruction and repeated exposure to the target vocabulary had on the nature of the receptive- productive gap. A total of sixty-two sixth grade students from a Government school in Tamil Nadu, India, participated in the experimental study which was conducted over a period of three months. The results of the study showed that the explicit instruction and repeated exposure to the target vocabulary had a significant amount of influence on vocabulary knowledge when compared to the conventional way of vocabulary instruction. In the conventional mode of vocabulary instruction, reception of vocabulary was found to have an average of 8% influence on the production knowledge, whereas in the case of the experimental group, it amounted up to 72%. This analysis showed that through explicit instruction and repeated exposure to the target vocabulary the receptive- productive gap is significantly reduced. 2020 JLLS and the Authors - Published by JLLS.