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Development of ?-carrageenan-based transparent and absorbent biodegradable films for wound dressing applications
Wound healing remains a critical challenge in healthcare, requiring advanced wound dressings with superior properties like transparency, absorbency, and biocompatibility. However, gaps exist in the use of marine-derived biopolymers for sustainable dressings. This study addresses this gap by combining ?-carrageenan (KC) with polyvinyl pyrrolidone (PVP) to develop transparent and absorbent biodegradable films through solvent casting and lyophilization techniques. Lyophilized films exhibited superior absorbency (9.17 g/cm2) and moisture management, with a water vapour transmission rate of 3990.67 g/m2/24 h, while solvent-cast films showed 78 % transmittance, enabling wound visualization. Mechanical testing revealed high tensile strength (31.5 MPa) and folding endurance (410 folds), ensuring durability. In vitro bactericidal assays confirmed efficacy against MRSA and E. coli, and in vivo tests on Wistar rats showed complete wound healing within 16 days with 91.1 % closure, outperforming untreated controls (76.7 %). This is the first study to explore lyophilized KC-PVP films for wound dressing applications, demonstrating potential for drug release, absorbency, and biodegradability. The innovative combination of biopolymers and fabrication techniques offers a sustainable, high-performance solution for wound care. 2024 Elsevier B.V. -
Development of a fluorescent scaffold by utilizing quercetin template for selective detection of Hg2+: Experimental and theoretical studies along with live cell imaging
Quercetin is an important antioxidant with high bioactivity and it has been used as SARS-CoV-2 inhibitor significantly. Quercetin, one of the most abundant flavonoids in nature, has been in the spot of numerous experimental and theoretical studies in the past decade due to its great biological and medicinal importance. But there have been limited instances of employing quercetin and its derivatives as a fluorescent framework for specific detection of various cations and anions in the chemosensing field. Therefore, we have developed a novel chemosensor based on quercetin coupled benzyl ethers (QBE) for selective detection of Hg2+ with naked-eye colorimetric and turn-on fluorometric response. Initially QBE itself exhibited very weak fluorescence with low quantum yield (? = 0.009) due to operating photoinduced electron transfer (PET) and inhibition of excited state intramolecular proton transfer (ESIPT) as well as intramolecular charge transfer (ICT) within the molecule. But in presence of Hg2+, QBE showed a sharp increase in fluorescence intensity by 18-fold at wavelength 444 nm with high quantum yield (? = 0.159) for the chelation-enhanced fluorescence (CHEF) with coordination of Hg2+, which hampers PET within the molecule. The strong binding affinity of QBE towards Hg2+ has been proved by lower detection limit at 8.47 M and high binding constant value as 2 104 M?1. The binding mechanism has been verified by DFT study, Cyclic voltammograms and Jobs plot analysis. For the practical application, the binding selectivity of QBE with Hg2+ has been capitalized in physiological medium to detect intracellular Hg2+ levels in living plant tissue by using green gram seeds. Thus, employing QBE as a fluorescent chemosensor for the specific identification of Hg2+ will pave the way for a novel approach to simplifying the creation of various chemosensors based on quercetin backbone for the precise detection of various biologically significant analytes. 2024 Elsevier B.V. -
Development of a scorecard to measure the satisfaction and happiness in higher education
This study aims to identify and test the antecedents affecting students' satisfaction and its relationship with happiness. A conceptual model was designed with the dimensions such as happiness, recognition, gratitude, physical health, and negative emotion to measure students' satisfaction. Martin Seligman's 'theory of well-being' was employed to measure the happiness of the students. Data was collected from 202 respondents and a structural equation modelling (SEM) approach was employed for analysis. The results of the study indicate that physical health, gratitude, and negative emotion influence the satisfaction of students in higher education. It was found that positive emotion and relationships have a significant influence on the happiness of the students. A relationship between satisfaction and happiness was developed. In extension to the present study's findings, a model and scorecard are proposed that can be used to measure the happiness and satisfaction of students in higher educational institutions in India. 2024 Inderscience Enterprises Ltd.. All rights reserved. -
Development of a Supported Education Program for Students with Severe Mental Disorders in India
Background: The onset of severe mental disorders (SMDs) is during adolescence or young adulthood, which affects the well-being and the educational aspirations of the students. Models of supported education practiced in the West are not culturally suitable for Indian students or the Indian education system. This study aimed to develop a Supported Education Program (SEP) for students with SMDs to help them with academic reintegration in an Indian context. Methods and Material: To develop the SEP, a realist review was done, followed by an in-depth interview with eight mental health professionals (MHP) and nine lecturers, using a validated interview script. After each interview, interim analysis and modifications were done to improve the rigor of the interview. After all interviews, the SEP was circulated for a second round of iteration for consensual validation by four mental health experts. The outcome of the entire process was the final version of SEP for students with SMDs. Results: The final SEP had two broad themes and 18 subthemes from the qualitative thematic analysis: theme 1 included issues and strategies relevant to the client or caregivers, and theme 2 was pertinent to the education system. Conclusion: The SEP developed and validated for people with SMDs has distinctive components: one for the individual and caregiver and the other for the educational system. 2020 Indian Psychiatric Society - South Zonal Branch. -
Development of an Efficient and Secured E-Voting Mobile Application Using Android
Smart technologies, particularly the development of the Internet, are employed to enhance the quality of human existence. Thanks to the Internet's explosive expansion, more and more tasks can now be completed quickly and easily compared to the earlier times. E-voting is a relatively recent field that has been identified. Voting can be conducted in a variety of methods, including in person at a polling place, online, and via a mobile application. The security of applications cannot be disregarded given the internet's explosive growth. In order to prevent phishing attacks, we created an Android application and included a 3-step security process before voting. Students can now vote online from any location at any time using a mobile device. Android Studio is used to create and deploy the application. While creating the voting application, this research adheres to the software development life cycle. The result of this research is the creation of a mobile application that is user-friendly for students and serves as a practical tool for letting them vote with three levels of security. 2022 Anli Sherine et al. -
Development of an efficient real-time H.264/AVC advanced video compression encryption scheme
Multimedia is the combination of media such as text, graphics, video clips, and audio files. In todays world, multimedia plays an important role in many applications that we use in our daily lives. It is used in educational software, animation, sound, and text, as well as multi-media software. H.264/AVC video compression is extremely efficient in terms of compression. Despite this, H.264/AVC requires a lot of processing and consumes a lot of power insdespite of the fact that its compression efficiency is lower than that of H.264/AVC. We examine the various methods of Video H.264 Advanced Video Compression Standard Encryption Schemes in this paper. The performance of all types of encryption techniques will be evaluated using parameters such as cost overhead, delay, and encryption quality. This will provide us with a detailed comparative analysis of video encryption schemes, allowing us to determine which one is far more efficient for H.264/AVC. 2021 Taru Publications. -
Development of Biocompatible Barium peroxide/Pluronic F127/L-ornithine Composite for Enriched Antimicrobial, Antioxidant and Anticancer Potential: An in vitro Study
Osteosarcoma (MG-63) is a type of bone cancer affects mostly adolescents and young adults. Disease-causing microorganisms like Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Candida albicans pose serious illness in humans. There is a need to develop multifunctional composite to combat cancer and other most common disease caused by disease causing microorganisms. In this context, BaO2 and pluronic F127, L-Ornithine coated BaO2 (BaO2-PF127-LO) composite have been prepared and characterized by XRD, FTIR, UV-Vis, SEM, HRTEM, EDAX, and XPS analytical techniques. BaO2 and BaO2-PF127-LO were orthorhombic crystalline structure and the crystallite size was found as 32nm for BaO2 and 26nm for modified BaO2 PL studies revealed the green emission observed at 506nm for BaO2-PF127-LO composite which is absent in the case of bare BaO2. Antimicrobial activity of BaO2 and BaO2-PF127-LO was investigated. MTT assay was performed to determine the anticancer potential while the DPPH free radical scavenging assay was carried out to determine the antioxidant potential. The experiment study revealed that the BaO2-PF127-LO exhibited enhanced antimicrobial, antioxidant, and anticancer activity and low toxicity when compared to pristine BaO2. The experimental results revealed that the BaO2-PF127-LO composite holds promising potential for biomedical applications. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. -
Development of CeO2ZrO2 bimetallic oxide catalyst for quinoxaline synthesis
In recent years, heterogeneous catalysts have led to environment-friendly transformations with better yields and reusability. Pd, one of the initial metals employed in heterogeneous organic synthesis, suffered from limitations like its high cost. This justifies the need for development of catalysts with abundant, low-cost metals, which has been receiving a lot of attention in the scientific community. In this work, a bimetallic oxide catalyst, CeO2ZrO2, is synthesized by a solgel route. The structure and morphology of the catalyst are investigated using X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray analysis, thermogravimetric analysis, BrunauerEmmettTeller measurements, and temperature-programmed desorption. It is utilized for obtaining quinoxaline derivatives at room temperature. 2,3-Diphenylquinoxaline is obtained via a simple condensation reaction between 1,2-diaminobenzene and 1,2-diketones, catalyzed by CeO2(50)ZrO2(50) with 87% yield in 15 min. Quinoxalines are known for their biological and therapeutic activities; hence, they are essential molecules. The biological activity of the synthesized quinoxaline derivatives has been evaluated against bacterial and fungal strains. 2023 Society of Chemical Industry. 2023 Society of Chemical Industry. -
Development of classical swine fever virus E2-protein based indirect ELISA for detection of antibodies against the virus in pigs
Classical swine fever (CSF) is an economically important and highly contagious disease of pigs caused by CSF virus, genus Pestivirus. Serological diagnosis of the disease is highly valuable for surveillance and thereby containment of spread of the disease. In this study, we have demonstrated the development of CSFV envelope glycoprotein E2-based indirect ELISA (E2-iELISA) for the detection of CSFV specific antibodies. The full-length E2 protein was expressed in E. coli and the purified protein was used as a coating antigen in indirect ELISA for detecting CSFV specific antibodies in pigs. A panel of 506 pig sera samples was used to validate the ELISA and the results were highly comparable to the results obtained with the commercial antibody detection kit (PrioCHECK CSFV Ab kit). The in-house E2-iELISA demonstrated high diagnostic sensitivity (95.4%) and specificity (95.5%), highlighting its potential application for sero-surveillance or monitoring of the disease in the swine population. The Author(s), under exclusive licence to Springer Nature B.V. 2024. -
Development of Genetic Algorithm Based Neural Network Model for Predicting Strength of High Performance Concrete
Volume 3, Issue -2, ISSN: 2248-9622 -
Development of Genetic Algorithm based Neural Network Model for Predicting Workability and Strength of High Performance Concrete
International Journal of Inventive Engineering and Sciences (IJIES), Vol.2, Issue 6, ISSN : 2319-9598. -
Development of Genetic Algorithm based Neural Network Model For Predicting Workability and strength of High Performance Concrete.
Volume-2 Issue-6, May, ISSN 23199598 -
Development of Green Synthesized Novel Carbon Dots from Ruta Graveolens L. for Fluorescent and Intracellular Sensing of Mercury Ions in Pico-molar (pm) Concentration
Green nanotechnology, which uses carbon nanomaterials for environmental remediation, is the pioneer among the prevailing approaches for the production and characterization. In the present study, highly fluorescent carbon dots (CDs) from Ruta Graveolens (ARH-CD) is developed, and its efficacy as a fluorescent sensor and biomarker is investigated. They act as a fluorescence sensor for Hg2+ over an extensive concentration range of 1 picomolar (pm) to 1 molar (m), with a detection limit as low as 26.75 pm. The studies reveal ARH-CD as an effective biomarker for intracellular toxicity analysis and a fluorescent probe for multi-colored (blue, green, and red) imaging of HEK293 cell lines. After 24 h of incubation, it is found that the ARH material reveals noticeable biocompatibility and visible fluorescence, with a viability of 98.88% at 5 gmL?1 and over 78.33% even at a concentration of 100 gmL?1. The IC50 value for the MTT assay for cell viability results is calculated to be 224.56 4.67 g, which further confirms the appreciable biocompatibility of the ARH-CD. The obtained samples are effective in being inspected for the intracellular detection of Hg2+ and serve as a possible candidate for cell imaging. 2024 Wiley-VCH GmbH. -
Development of Guidelines for Spouses Engaged in Home-Based Care of Persons With Motor Neuron Disease From Indian Context
Background: The caregivers of persons with motor neuron disease (MND) have several needs that are usually not voiced on any platform. Aim: To explore the lived experience of spouses of persons with MND, identify their needs and develop guidelines for better home-based care. Method: An exploratory study with 3-point in-depth interviews among 13 participants was conducted. Participants were the spouses of persons with MND under treatment at a national quaternary referral center. The interpretative phenomenological analysis identified participants needs. These needs, with literature review synthesis, guided the drafting of guidelines, which was validated by experts. Results: The needs were emotional, social, care systems, and skills. The guidelines developed contained 2 sections (1) Information for the spouses: understanding MND, communication, symptom management, marital relationship, palliative care, and everyday life made easier. (2) Well-being of the spouse caregivers: well-being of the spouse caregivers, self-care, mental health, supporting carers in palliative care, where to find help. Conclusion: The guidelines can be developed as a manual for the caregivers and for training healthcare professionals working with neurodegenerative conditions. The Author(s) 2022. -
Development of perceived prenatal maternal stress scale
Background: Pregnancy is a state, which is often associated with extreme joy and happiness. Women undergo a number of physiological and psychological changes during pregnancy, which are often stressful if aligned with other adverse life events, compromising their health and well-being. However, there exists no comprehensive psychological instruments for measuring this stress. Objectives: The study was conducted to develop a multidimensional scale to assess prenatal maternal stress (PNMS) comprehensively. Methods: The initial phase of the study focuses on developing items and assessing the content validity of these items. The second phase focuses on pilot-testing and field-testing the newly developed perceived PNMS scale (PPNMSS) among 356 pregnant women belonging to different parity and trimester from November 2015 to October 2016. Results: The underlying factor structure of the 28-item PPNMSS had explored using exploratory factor analysis. The final scale is retained with 15 items having considerable item loading under four major factors as follows: perceived social support, pregnancy-specific concerns, intimate partner relations, and financial concerns. Reliability of each of these dimensions was assessed using Cronbach's alpha. Convergent and divergent validity of the scale was assessed by correlating the scores with perceived stress scale and the World Health Organization (five) well-being index (1998 version). Conclusions: As a comprehensive scale, PPNMSS is efficient to measure PNMS, which facilitates an early detection of stress and depression among pregnant women and timely intervention by health care professionals. -
Development of smart energy monitoring using NB-IOT and cloud
IoT-based applications are growing in popularity nowadays because they offer effective answers to numerous current problems. In this research, With the aim of decreasing human efforts for monitoring the power units and increasing users' knowledge of excessive electricity usage, an IoT-based electric metre surveillance system utilising an Android platform has been developed. With the help of an Arduino Uno and an optical sensor, the electric analyser pulse is captured. To reduce human mistake and the expense of energy usage, a low-cost wireless network of sensors for digital energy metres is implemented alongside a smartphone application that can autonomously read the metre of the unit. In this research, an intelligent power monitoring system with effective communication modules has been developed to make wise use of the electricity. The controller, NB-IoT connection module, and cloud are the three main components of an IOT-based smart energy metre system. The controller is essential for maintaining the functionality of each component. This solution reduces the need for human involvement in electricity maintenance by connecting energy metres to the cloud using an NB-IoT communication module. The IoT-based metre reading system in the proposed work is created to monitor and analyse the metre reading, and the service provider can cut off the source of electricity whenever the customer fails to pay the monthly bill. It also eliminates the need for human intervention, provides accurate metre reading, and guards against billing errors. The proposed SPM improves the overall accuracy ranges of 7.42, 27.83, and 20% better than DR, OREM, and SLN respectively. 2023 -
Development of the House of Collaborative Partnership to overcome supply chain disruptions: evidence from the textile industry in India
Collaboration in a supply chain becomes a significant competitive weapon for member firms in an uncertain business environment. The present study develops a model of supply chain collaboration named as House of Collaborative Partnership (HCP) and includes the enablers and impeders of a successful Collaborative Partnership (CP). Model development follows a three-phase process. The first phase consists of the identification of enablers and impeders of CP based on the literature review and experts opinions. The second phase applies Total Interpretive Structural Modelling (TISM) as a tool to construct hierarchical structures of the enablers and impeders of CP. The third phase deals with the development of HCP based on the hierarchical structures of enablers and impeders. The HCP is then validated with two case studies in the Indian textile industry. Eight enablers and seven impeders were identified in the first phase. After analyzing these factors with TISM, the HCP was developed consisting of four parts: Foundation, Columns, Beam, and Roof. The existence of trust, commitment to long-term collaboration, top management support, adequate financial support, ability to deal with technological changes, and providing regular training to employees constitute the HCP Foundation to achieve supply chain collaboration. The study concludes with the managerial implications of HCP to help supply chain partners in becoming resilient during an uncertain business environment. 2022 Informa UK Limited, trading as Taylor & Francis Group. -
Development through ICT: A study on teachers perspectives on challenges in online education for tribal students amid COVID-19
Online education became an integral part of the education system during the COVID-19 pandemic. All the schools, colleges and universities adopted new technology in teaching-learning pedagogy. Academicians and students were taught to practice online education with many challenges and difficulties. The Constitution of India includes many beneficial provisions to promote the integral development of scheduled tribes. It enables them and protects them from socioeconomic status and forms of exploitation. In Kerala, the Scheduled Tribes Development Department is implementing various programs for the educational, social and economic development of Scheduled Tribes. Kerala is the most literate state in India. It creates a strong academic foundation at the school level. Even though the COVID-19 pandemic spread throughout the world, the government continued education in the state through the VICTERS educational television channel with the help of various ICT tools. This studys objective is to determine the challenges faced by tribal students in the Idukki District of Kerala State in online education and to understand the social and technological challenges they face in the learning process. An in-depth interview method was adopted for the study. This qualitative study explored the perspectives of teachers who teach tribal students. 2025 Malque Publishing. All rights reserved. -
Development vs. Rights A Case for Sustainable Development of Onge Tribes of Little Andaman
Human rights and environmental protections are often violated as a consequence of development activities. In addition to harming the environment, this increases the marginalisation of those who are already marginalised. The development paradigm that is based on the interests of the majority not only tends to retard the indigenous people but also renders them incapable of competing with the majority. For the indigenous people, development has always been a problem rather than a solution. Development initiatives under the umbrella of globalisation with a label of monotony, ignore the aspects of the diverse livelihoods of many indigenous peoples. The Niti Aayog proposed in its vision document, the Sustainable Development of Little Andaman, in 2021, that the island should be developed into a megacity by utilising its natural features and strategic location. The long-term objective is to develop the island into a major financial tourism hub that can rival Hong Kong and Singapore. This plan will, on the one hand, advance commerce, employment, and economic growth; on the other hand, environmental conservation issues will also arise. Concerns over this vision document have indeed been voiced by several academics, environmentalists, and conservationists due to issues with Onge indigenous rights, ecological fragility, and earthquake and tsunami susceptibility. In this context, the research article aims to study and analyse the proposed megacity project and its impact on the rights of Onge tribes and the environment. Sahana Florence and Achyutananda Mishra, 2024. -
DFT electronic structure calculations, spectroscopic studies, and normal coordinate analysis of 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate
The solid phase FTIR and FT-Raman spectra of 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate (25N2LCPA) have been recorded 450-4000 cm-1 and 100-4000 cm-1 respectively. The normal coordinate analysis was carried out to confirm the precision of the assignments. DFT calculations have been performed giving energies, optimized structures, harmonic vibrational frequencies and IR intensities. The structure of the molecule was optimized and the structural characteristics were determined by density functional theory (DFT) using B3LYP method with 6-31+G(d,p) basis set. The detailed interpretation of the vibrational spectra has been carried out with aid of normal coordinate analysis (NCA) following the scaled quantum mechanical force field methodology. The Vibrational frequencies are calculated in the above method and are compared with experimental frequencies which yield good agreement between observed and calculated frequencies. Stability of the molecule arising from hyper conjugative interactions, charge delocalization has been analyzed using natural bond orbital (NBO) analysis. In addition, Frontiers molecular orbital and molecular electrostatic potential were computed by using Density Functional Theory (DFT) B3LYP/6-31+G(d,p) basis set. The calculated HOMO and LUMO energies show that charge transfer occurs in the molecule. 2014 Elsevier B.V. All rights reserved.