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Essential Oil from Coriandrum sativum: A review on Its Phytochemistry and Biological Activity
Essential oils are hydrophobic liquids produced as secondary metabolites by specialized secretory tissues in the leaves, seeds, flowers, bark and wood of the plant, and they play an important ecological role in plants. Essential oils have been used in various traditional healing systems due to their pharmaceutical properties, and are reported to be a suitable replacement for chemical and synthetic drugs that come with adverse side effects. Thus, currently, various plant sources for essential oil production have been explored. Coriander essential oil, obtained from the leaf and seed oil of Coriandrum sativum, has been reported to have various biological activities. Apart from its application in food preservation, the oil has many pharmacological properties, including allelopathic properties. The present review discusses the phytochemical composition of the seed and leaf oil of coriander and the variation of the essential oil across various germplasms, accessions, at different growth stages and across various regions. Furthermore, the study explores various extraction and quantification methods for coriander essential oils. The study also provides detailed information on various pharmacological properties of essential oils, such as antimicrobial, anthelmintic, insecticidal, allelopathic, antioxidant, antidiabetic, anticonvulsive, antidepressant, and hepatoprotective properties, as well as playing a major role in maintaining good digestive health. Coriander essential oil is one of the most promising alternatives in the food and pharmaceutical industries. 2023 by the authors. -
Review on the Biogenesis of Platelets in Lungs and Its Alterations in SARS-CoV-2 Infection Patients
Thrombocytes (platelets) are the type of blood cells that are involved in hemostasis, thrombosis, etc. For the conversion of megakaryocytes into thrombocytes, the thrombopoietin (TPO) protein is essential which is encoded by the TPO gene. TPO gene is present in the long arm of chromosome number 3 (3q26). This TPO protein interacts with the c-Mpl receptor, which is present on the outer surface of megakaryocytes. As a result, megakaryocyte breaks into the production of functional thrombocytes. Some of the evidence shows that the megakaryocytes, the precursor of thrombocytes, are seen in the lungs interstitium. This review focuses on the involvement of the lungs in the production of thrombocytes and their mechanism. A lot of findings show that viral diseases, which affect the lungs, cause thrombocytopenia in human beings. One of the notable viral diseases is COVID-19 or severe acute respiratory syndrome caused by SARS-associated coronavirus 2 (SARS-CoV-2). SARS-CoV-2 caused a worldwide alarm in 2019 and a lot of people suffered because of this disease. It mainly targets the lung cells for its replication. To enter the cells, these virus targets the angiotensin-converting enzyme-2 (ACE-2) receptors that are abundantly seen on the surface of the lung cells. Recent reports of COVID-19-affected patients reveal the important fact that these peoples develop thrombocytopenia as a post-COVID condition. This review elaborates on the biogenesis of platelets in the lungs and the alterations of thrombocytes during the COVID-19 infection. 2023, SAGE Publications Ltd. All rights reserved. -
Green-synthesized nanoparticles and their therapeutic applications: A review
Antibiotic-resistant microorganisms are a rising issue when it comes to human health. Microbial pathogens that cause harmful infections are quickly becoming resistant to the antimicrobial action of traditional antibiotics. Nanotechnology, an innovative sector being an indispensable part of healthcare and research, has in-depth and extensive applications. Nano-compounds have been promising antimicrobial agents, anti-cancerous mediators, vehicles for drug delivery, formulations for functional foods, identification of pathogens, food and drug packaging industry, and many more. However, the chemical synthesis of nanoparticles (NPs) has certain drawbacks such as causing toxicity and other adverse effects. For more than a decade, the use of NPs that are conjugated or green-synthesized has gained popularity due to the two-fold action of metallic NPs mixed with biological sources. In contrast, NPs synthesized using plant or microbial extracts, conjugated with biologically active components, appear to be a safe alternative approach as they are environmentally friendly and cost-effective. Such environmentally safe techniques are referred to as "green nanotechnology"or "clean technology"and are feasible alternatives to chemical methods. Furthermore, NPs conjugated with natural biomolecules have improved bioavailability and have minimal side effects, as they are smaller in size and have higher permeability in addition to being reducing and stabilizing agents possessing excellent antioxidant activity. NPs serve as potential antimicrobial agents due to their affinity towards sulphur-rich amino acids, adhere to microbial cell walls by means of electrostatic attraction, and disrupt the cytoplasmic membrane along with the nucleic acid of microbes. They possess anticancer activity owing to oxidative stress, damage to cellular DNA, and lipid peroxidation. The green-synthesized NPs are thus a promising and safe alternative for healthcare therapeutic applications. 2023 the author(s), published by De Gruyter. -
Bioreactor systems for micropropagation of plants: present scenario and future prospects
Plant micropropagation has been adapted in the fields of agriculture, horticulture, forestry, and other related fields for large-scale production of elite plants. The use of liquid media and adoption of bioreactors have escalated the production of healthy plants. Several liquid-phase, gas-phase, temporary immersion, and other modified bioreactors have been used for plant propagation. The design, principle, operational mode, merits, and demerits of various bioreactors used for the regeneration of propagules, such as bulblets, cormlets, rhizomes, microtubers, shoots (subsequent rooting), and somatic embryos, are discussed here. In addition, various parameters that affect plant regeneration are discussed with suitable examples. Copyright 2023 Murthy, Joseph, Paek and Park. -
Disclosure of University Social Responsibility A Review of Select Higher Educational Institutions
This paper explores the disclosure of university social responsibility by higher educational institutions. Based on the disclosure of information on institutional websites, 39 universities were selected for the study. The data, which was assessed on the criteria used by regulatory authorities for grading institutions, revealed that while 12 institutions performed above average in most of the criteria, 17 were in the medium range, and 10 performed below average. The study proposes that disclosure of social responsibility activities with adequate evidence from institutional websites can attract more viewers and prospective students. 2023 Tata Institute of Social Sciences. All rights reserved. -
A Survey on P4 Challenges in Software Defined Networks: P4 Programming
Software Defined Networking (SDN) has been a prominent technology in the last decade that increases networking programmability. The SDN philosophy decouples the application, control, and data plane to increase the network programmability. The data plane is an essential but unsolved component that receives less attention than control and application planes. Traditionally, the data plane uses fixed functions that forward packets using a limited number of protocols. The P4 (Programming Protocol-independent Packet Processors) language makes it possible to program SDN data plane, which push the SDN to the next level. In the research community and industry, programming the data plane has garnered significant attention. Surprisingly, there has been no comprehensive reviews of programmable data-plane switches, which have many advantages in today's networks. The authors reviewed the evolution of networks from legacy to programmable data planes, explained the fundamentals of programmable switches, and summarized the network generation from traditional to programmable networks. In this paper, SDN is described from a P4-centric standpoint and discusses over 75 related research papers. Several taxonomies for the field are provided, outline potential research areas, and provide greater details regarding the patterns that have led to the development of this technology. 2013 IEEE. -
A Review on Advanced Nanomaterials for Antibacterial Applications
The management of infectious diseases is one of the major public health challenges of the 21st century. Mutation of the microbes, biofilm formation, and other structural-morpholo-gical behaviors have resulted in pathogens acquiring multi-drug resistance. The development of advanced materials that can provide long-lasting and effective protection against harmful microbes is becoming a need of the hour. Biocompatibility, efficient microbial inactivation, thermal and chemical stability of nanomaterials help to reduce the excessive use of antibiotics and, thus, to overcome antimicrobial resistance. Metal and metal oxide nanostructures, graphene, carbon dots, and other two-dimensional materials exhibit excellent antimicrobial properties. This review provides a comprehensive overview of antibacterial mechanisms and factors that help to inactivate the bacteria by nanomaterials. It also points out the enhanced antibacterial behaviors of the modified nanomaterials for future research concerns. 2023 Bentham Science Publishers. -
Examining the Domain of Green Finance Through Bibliometric Research Analysis of 22 Years (20002022): An Analytical Retrospective
Green finance has evolved as a concept aiming to integrate environmental protection and economic profits. Growing global concern towards climate change, greenhouse gas emissions, industrial pollution control, waste management, and environmental protection has caught the attention of countries and policymakers towards innovative financial products and services that are used to address a broader range of environmental concerns. Financial instruments such as green bonds, green stocks and loans effectively guide capital investment towards environment-friendly projects and promote the United Nations sustainable development goals. Thus, green finance is considered a compelling concept that plays a vital role in promoting sustainability. The authors used the Scopus database to perform a bibliometric review of green finance from 2001 to 2022 to determine the current trend and progress in the field. The article presents a thorough bibliometric and temporal analysis that provides inputs that other researchers on this topic have not evaluated. VoS Viewer and Biblioshiny. The software was used to visually analyse the data and identify patterns of co-occurrences and prominent research themes. The graphical and systematic mapping illustrates the evolution in publications over time and identifies areas of current research interests. The findings show that the research on green finance has gained momentum from 2014 onwards. The analysis provides a comprehensive overview of the green finance-related research, which will help the researchers and policymakers to examine better the trends and future direction of the development of green finance. 2023 MDI. -
Eco-friendly synthesized nanoparticles as antimicrobial agents: an updated review
Green synthesis of NPs has gained extensive acceptance as they are reliable, eco-friendly, sustainable, and stable. Chemically synthesized NPs cause lung inflammation, heart problems, liver dysfunction, immune suppression, organ accumulation, and altered metabolism, leading to organ-specific toxicity. NPs synthesized from plants and microbes are biologically safe and cost-effective. These microbes and plant sources can consume and accumulate inorganic metal ions from their adjacent niches, thus synthesizing extracellular and intracellular NPs. These inherent characteristics of biological cells to process and modify inorganic metal ions into NPs have helped explore an area of biochemical analysis. Biological entities or their extracts used in NPs include algae, bacteria, fungi, actinomycetes, viruses, yeasts, and plants, with varying capabilities through the bioreduction of metallic NPs. These biosynthesized NPs have a wide range of pharmaceutical applications, such as tissue engineering, detection of pathogens or proteins, antimicrobial agents, anticancer mediators, vehicles for drug delivery, formulations for functional foods, and identification of pathogens, which can contribute to translational research in medical applications. NPs have various applications in the food and drug packaging industry, agriculture, and environmental remediation. Copyright 2023 Borehalli Mayegowda, Roy, N. G., Pandit, Alghamdi, Almehmadi, Allahyani, Awwad and Sharma. -
Effectiveness of dialectical behavior therapy as a transdiagnostic treatment for improving cognitive functions: a systematic review
Dialectical behavior therapy (DBT) has been found to be an efficacious treatment for disorders characterized by high levels of emotional instability. In view of the multifaceted applications of DBT and the extent to which mental disorders can incapacitate cognitive functions, the current systematic review aimed to investigate the effect of DBT in strengthening cognitive functions across various mental health conditions. Original research studies employing both experimental and quasi-experimental designs were included in the review. The literature search was done using different electronic databases, from the first available literature until June 2022, that covered an approximate period of ten years. Joanna Briggs Institute checklist was used to assess the methodological rigor of the studies. Twelve studies conducted on adolescents with emotional dysregulation, and adults with borderline personality disorder, bipolar disorder, attention deficit hyperactivity disorder, and multiple sclerosis were selected. Results indicate that DBT has the potential to improve key cognitive functions such as attention, memory, fluency, response inhibition, planning, set shifting, tolerance for delayed rewards and time perception, as assessed by neuropsychological tests, self-report of cognitive functions, and neuroimaging techniques. Considering the review's findings that showcase the effectiveness of DBT in fostering improvements in cognitive functions, DBT may possibly be chosen as a preferred treatment to ensure that patients reach optimal levels of cognitive functioning. Limitations include lack of sufficient studies encompassing all the common mental health conditions, usage of neuroimaging techniques as only an indirect measure of cognitive functioning and nuances related to the quality of individual studies. Author(s), 2023. -
ANALYTICAL METHODS FOR TRAMADOL IN PHARMACEUTICAL AND FORENSIC CONTEXT A REVIEW
Tramadol is a centrally-acting weak opioid recept or analgesic and is a racemic mixture of (+)-tramadol and ()-tramadol enantiomers. Tramadol does not show many adverse severe effects without any dependency potential in therapeutic doses, as seen in other opioids only if not used for extended periods in doses higher than recommended. Symptoms of tramadol intoxication are similar to those of other opioid analgesics but may include serotonergic and noradrenergic components. Fatal intoxications are rare and appear synergetic with other drugs and alcohol. There is growing evidence of abuse of tramadol in many countries. Due to its extensive use in the medical field as an analgesic of choice, pharmaceutical analysis in both process and quality control is essential. Due to its abuse and overdose cases, forensic toxicological analysis of tramadol in body fluids and tissues is also vital in medico-legal practice. Tramadol and its metabolites are found in wastewater also. This analytical review (from 2016-2021) focuses on identifying and determining t ramadol in bulk dr ugs, formulations, forensic drug seizures, forensic toxicological specimens, and wastewater. The analytical methods covered include UV/Visible/IR spectrophotometric methods, thin-l ayer, gas and li quid chromat ographic met hods, electrochemical methods, GC-MS, LC-MS, LC-MS-MS methods, and electrochemical methods. The review will i nt eres t phar maceut i cal chemi st s, pharmacol ogis ts, biochemists, forensic chemists, forensic toxicologists, and environmental scientists. 2023, Medico Legal Society. All rights reserved. -
Functional Foods: Exploring the Health Benefits of Bioactive Compounds from Plant and Animal Sources
"Let food be the medicine"(Hippocrates) is a historic quote that became the basis of food science and nutraceuticals. Due to their possible therapeutic advantages, extracts from food have attracted much interest in the medical community. These extracts are abundant in bioactive compounds, which are natural molecules that may be found in various foods and have been demonstrated to affect health positively. Food components have lots of bioactive components, including primary and secondary metabolites and nutritional components, for example, carbohydrates, proteins, vitamins, minerals, fatty acids, antioxidants, phenolics, and flavonoids. This study's primary focus is on the make-up and purpose of these bioactive components found in food extracts. This review aims to give readers a thorough grasp of the bioactive substances found in food extracts and their possible physiological uses. These bioactive substances' functional traits, such as their antioxidant, anti-inflammatory, antibacterial, anticancer, and neuroprotective actions, are also studied. Further research is required to create new functional foods, nutraceuticals, and dietary supplements with specific health advantages that can benefit from understanding these molecules' structure and function. 2023 Versha Dixit et al. -
Tuning the output of the higher plants Circadian Clock
The circadian clock is an ascribed regulator found in the cells of creatures, that keeps biological and behavioral processes in stnc with dailt environmental changes throughout the 24-hour ctcles. When the circadian clock in humans malfunctions or is misaligned with environmental signals, the timing of the sleep-wake ctcle is altered and several circadian rhtthm sleep disorders result. Due to the Earth's rotation on its axis, predictable environmental changes are anticipated bt complex processes. The combined term for these ststems is the circadian clock. The circadian rhtthm regulates photostnthesis and photoperiodism, making it the "primart controller of plant life." The circadian clock is made up of post-translational alterations to core oscillators, epigenetic tweaks to DNA and histones, and auto regulatort feedback loops in transcription. In addition, the circadian clock is cell-autonomous and regulates the circadian rhtthms of distinct organs. Biochemical elements such as photostnthetic products, mineral nutrients, calcium ions, and hormones are used bt the core oscillators to communicate with one another. Arabidopsis is utilized to identift clock-related genes that govern plant growth, germination, pollination, flowering, abiotic and biotic stress responses, and more. The biological ctcles of all species, notablt humans, are undoubtedlt impacted bt other elements, including high altitude and changing ecoststems, in addition to the ones alreadt stated. Although it hasn't tet published ant experimental or scientific evidence to support them, the implication that living things have lives does appear inescapable. Hence, the present studt elaborates on the higher plants related to the circadian clock. The Author(s). -
A review on anti-cancer plants of India
India has a high level of endemism and a diverse range of floral species. Cancer is one of the most significant challenges facing global health today. The indigenous peoples and residents who live in India have, for a very long time, made use of specific medicinal plants to fight cancer. This practice is still prevalent today. Several different drugs may be utilized in the treatment of cancer. Because of the potential drawbacks associated with such treatments and the development of drug resistance, the quest for new therapies that are both safer and much more effective is still the most challenging field of study. Several cancer medicines used today come from natural sources. We're returning to our old ways because medicinal plants are a good, natural way to make medicines that prevent cancer without causing major side effects. Within the scope of this study, a few herbs traditionally used to treat cancer are looked at to see what they might be good for. The cytotoxicity of these plants, the processes that lead to them, and the different compounds they make were looked into. This study has tried to focus on how these plants fight cancer. The Author(s). -
Responsible and sustainable lending by Financial institutions: a literature Review
The subject of the study is to use an extensive literature review to evaluate how academic research on corporate social responsibility (CSR) is developing. The journals and papers in the ISI Web of Science, SCOPUS, and Taylor&Francis databases served as the foundation for this literature review. The purpose of the study is to highlight essential papers, referenced journals importance, and potential future study directions. Determinants that impact the CSR performance of an organization are governance, profitability, firm characteristics, and minimum expenditure. The impact of CSR has been measured using accounting-based market value, risk, excess return on a stock, and moral capital. All the variables are discussed with strongly supported literature and then concluded by giving a framework. The novelty of our study is that it analyses new research trends while concentrating on the CSR research frontiers. The conclusion identifies possible areas for scientists to further develop their expertise, including sustainable and responsible financing and ESG strategy. Sachdeva S., Ramesh L., 2023. -
International investments and environmental protection in India - Policy and implementation gaps in mitigating the carbon footprints
Introduction: While India's contribution and progress on environment protection has been applauded by global leaders, India continues to be one of the biggest carbon and greenhouse gas (GHG) emitter globally. Major sectors responsible for carbon emissions are also the major sectors attracting international investments. This paper intends review such investments and examine their impact on environment. Methodology: A comprehensive review of the existing literature to identify the prevailing laws and policies that apply to corporations to meeting environmental standards was undertaken. In addition, extensive search was undertaken on the internet for reports and database that monitor corporate behavior and report about their disclosures and efforts on addressing environmental concerns. A review of the investment agreements signed, adopted and in-force in India was also undertaken to understand if they meet the standards of environmental protection. Data collection was done between July 2022 to June 2023. Findings: The Constitution of India stipulates protection and improvement of public and environmental health of the country. Several laws and policies have been adopted to meet this constitutional standard in India, including The National Action Plan on Climate Change (NAPCC). The 17 SDGs have direct and indirect linkages and impact on the environment. It is evident that all international investment agreements up to 2017 have no mention of environment exemption clause nor incorporates the GATT Article XX exceptions. However, the recent IIAs do mention environment as exception to expropriation. It is also seen that investments by big corporations have been responsible for huge deforestation, water pollution, and fossil fuel globally and most of them have their footprints in India and continue to contribute to the countries carbon footprint. India's commitment to renewable and non-conventional energy is the silver lining to meeting the SDG goals and the net zero emission targets. Meeting ESG standards and its disclosures by regulatory body is another positive step towards environmental protection from international investments. Conclusion: The biggest global contributors to GHG and carbon emissions have their presence in India and thus contribute to the overall carbon foot print of India. All international investments must be required to comply with the legal and policy regulations on public health and environment protection. In this regard, corporations should be mandated to follow ESG standards to meet the SDGs objectives. 2023 The Authors -
Biodiversity and Indigenous Medicinal Knowledge of North-East India: Navigating Climate Change Impacts on Medicinal Plants for Conservation and Advancement
The northeastern region of India holds the sixth position among the world's 25 biodiversity hotspots, covering approximately 8% of the nation's total land area, which amounts to 262, 060 square kilometres. Situated in the eastern Himalayas, any alterations in this biodiversity-rich area can have significant and far-reaching consequences. Indigenous tribes of this region believe in the remarkable healing properties of certain medicinal plants, and within its diverse population of around 225 communities, each tribal and sub -tribal group possesses distinct traditional knowledge. Capturing and harnessing this indigenous wisdom by scientists and researchers could unlock new avenues for progress, particularly within the pharmaceutical sector. Climate change stands as one of the paramount global environmental challenges. Predictions indicate that by the close of the 21st century, the Earth's average temperature might rise by anywhere between 0.3 to 4.8 C, accompanied by a potential sea level increase of 26 to 82 cm. These climate shifts could have adverse effects on the abundance and accessibility of medicinal plants, potentially leading to species extinction. Moreover, the impact of climate change could extend beyond availability to also encompass alterations in the pharmacological properties of various plants, particularly those found in alpine environments. This discussion underscores the importance of existing knowledge, critical analyses, challenges, opportunities, and the immense value of medicinal plants. It emphasizes the intersection of changing climate and the vulnerability of medicinal plant resources, necessitating a comprehensive understanding of these effects in the context of the North Eastern region of India. To address these challenges, there is a pressing need for in-depth research on the geographical distribution of plant communities and strategies to enhance the secondary synthesis of critically endangered medicinal plants under the current climate change scenarios. The Author(s). -
An extensive critique on expert system control in solar photovoltaic dominated microgrids
Solar and wind power have recently become a potential option in power systems and act significantly to meet load penetration demands. The present growth of such renewable energy sources has shown an exponential increase. The high penetration of such system helps a grid effectively meet its load in an irregular demand but also creates some disturbances in the grid due to frequent additions and detachments of load or source. The way by which the renewable energy sources usually work in the on-grid mode is to be attached to and cut down from the grids without creating disturbances in a stable grid. Another important requirement is effective load management with fewer transmission losses. This article presents a detailed review of a microgrid and enumerates the possible methods for the analysis of the system, feature extraction, control methods, and options for machine learning. This paper examines the factors affecting the operations in a power system, their nature, interdependability, and controllability. It also inspects the various machine learning algorithms, their feasibility, and possible applications in power systems. The major contribution of the paper is the elucidation of expert system control methods for the performance improvement of solar PV assisted DC microgrids. The major objective of the paper is to provide an overview on various algorithms intended for the microgrid systems pertaining to its accuracy, precision, classification, prediction and forecasting. 2023 The Authors. IET Renewable Power Generation published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology. -
Phytochemicals as weapons against drug resistance
Phytochemicals are plant-based products with high medicinal value. These metabolites effectively target disease-causing microbes. Drug-resistant pathogens have developed mechanisms to sustain themselves even with inhibitors. Drug resistance has emerged as a global giant, causing all available treatment options to fail. The solution to this problem is in the phytochemicals of plants with antibacterial and drug resistance modulation properties. Phytochemicals might be able to get rid of efflux pumps, drug-modulating enzymes, resistance genes, quorum sensing, and biofilm, all of which cause pathogens to be resistant to drugs. Moreover, anti-obesogenic and cardioprotective properties are also observed in phytochemicals. Additionally, studies show the success of phytochemical-based nanoparticles in drug resistance regulation. This review emphasizes phytochemicals' different mechanisms of action and their derivatives in curbing drug-resistant pathogens and cancer cells. 2023 The Author(s)