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Understanding the Role of Antimicrobial Peptides in Neutrophil Extracellular Traps Promoting Autoimmune Disorders
AMPs are small oligopeptides acting as integral elements of the innate immune system and are of tremendous potential in the medical field owing to their antimicrobial and immunomodulatory activities. They offer a multitude of immunomodulatory properties such as immune cell differentiation, inflammatory responses, cytokine production, and chemoattraction. Aberrancy in neutrophil or epithelial cell-producing AMPs leads to inflammation culminating in various autoimmune responses. In this review, we have tried to explore the role of prominent mammalian AMPsdefensins and cathelicidins, as immune regulators with special emphasis on their role in neutrophil extracellular traps which promotes autoimmune disorders. When complexed with self-DNA or self-RNA, AMPs act as autoantigens which activate plasmacytoid dendritic cells and myeloid dendritic cells leading to the production of interferons and cytokines. These trigger a series of self-directed inflammatory reactions, leading to the emergence of diverse autoimmune disorders. Since AMPs show both anti- and pro-inflammatory abilities in different ADs, there is a dire need for a complete understanding of their role before developing AMP-based therapy for autoimmune disorders. 2023 by the authors. -
Understanding the role of acid sites of Zinc Aluminophosphate catalysts in eco-friendly synthesis of carbamates
Aluminophosphate and metal incorporated aluminophosphates have been synthesized at ice-cold temperature by simple co-precipitation method in the absence of a templating agent. Surface and bulk properties of synthesized materials were studied by different characterization techniques. The materials were found to be X-ray amorphous. N2 adsorption-desorption studies exhibited the existence of microporous structure and uniform narrow slit type of pores on the materials. The catalytic activity of the synthesized material was tested in phosgene free synthesis of carbamates from corresponding amines and dimethyl carbonate (DMC) through a greener route. Metal incorporated Aluminophosphates indicated excellent catalytic activity compared to pure aluminophosphates. Zinc aluminophosphate catalyst exhibited 83% carbamate yield with 100% selectivity towards the formation of carbamate. The excellent catalytic activity of Zinc aluminophosphate with 94% amine conversion is attributed to its surface properties mainly moderate acid strength. The incorporated metal plays a vital role in the structural and textural properties of aluminophosphates. A systematic study was conducted to correlate the catalytic activity and surface properties of metal aluminophosphates. Reaction conditions were optimized to obtain a better yield through phosgene free eco-friendly routes using different amines. The catalyst was found to be recyclable for 5 cycles in the desired reaction without a reduction in conversion and selectivity. 2021. All Rights Reserved. -
Understanding The Pastoral Ethnobotany in Koppal and Vijayanagar Districts of Karnataka for Sustainability
The research aimed to comprehensively explore the ethnobotanical significance and nutritional value of wild plants utilized by pastoralists in Koppal and Vijayanagar districts. The study area selection involved meticulous consideration of the geographical and ecological relevance. Determining an appropriate sample size was crucial to ensure representative data collection, achieved through systematic methodologies. Informants were thoughtfully selected to gather newlineindigenous knowledge about the diverse uses of wild plants, emphasizing their fodder, newlineveterinary, edible, and medicinal applications. Employing ethnobotanical research methods, interviews were conducted to document plant usage, elucidate their taxonomical identities, and create an extensive inventory. The collection of plants referenced by pastoralists during interviews was a pivotal step. Detailed assessments of plant categories, habits, habitats, and newlinespecific plant parts used were documented. Herbarium preparation and authentication were newlineconducted meticulously to preserve and validate the collected plant specimens. newlineComparison with ethnobotanical studies from other subtropical regions worldwide was newlineconducted using the Jacquard index, revealing similarities and differences. The evaluation of sustainable utility focused on wild edible plants, analysing their viability for long-term utilization. Furthermore, investigating the forage quality of selected wild fodder and hay supplement plants was carried out. Analysing their proximate provided insights into their nutritional value. In summary, this comprehensive research delved into ethnobotanical practices, taxonomic identification, nutritional evaluation, and sustainable utilization of wild plants among pastoral communities. The findings not only contributed to ethnobotanical knowledge but also provided valuable insights into the potential economic and ecological significance of these plants for the communities involved. -
Understanding the impact of designs in visual aids in education /
Visual aids have played a significant role in understanding various messages. Visual aids serve as multipurpose effective tool in understanding concepts that are complex in nature. Not only does visual aids serve as classroom technique in the field of education but also enable the designers to collaborate with the academicians to create deigns that would bridge the gap between study material and better understandings. -
Understanding the impact of COVID-19 on the employee's productivity and performance of the hotel industries in India: An exploratory study
The covid-19 pandemic has brought unprecedented challenges and the hotel industry is amongst the other industry who was affected to a large extent, impacting various facets of well-being of the employees' working in the hotel industry. This research paper aims to comprehensively analyse the effect of the pandemic on hotel employees by investigating relationship between the impact of Covid 19, psychological impact, job satisfaction and turnover intention. We review the literature available about how the effects of Covid-19 Pandemic impact the employee job satisfaction as well as turnover intention. The study was carried out keeping the psychological impact of the pandemic as the mediator. We Reviewed and analyzed Scopus and ABDC listed research papers to carry out this literature review. Our results suggest that the covid-19 pandemic has impacted the turnover intention of the employee of the hotel industry, additionally the psychological impact mediates the relationship of Effect of Covid-19 pandemic with job satisfaction and turnover intention of employees. 2024, IGI Global. All rights reserved. -
Understanding the House Money Effect: A Systematic Review
The house money effect is the tendency of individuals to exhibit risk-seeking behavior after a prior gain. Individuals differentiate their perceived gains with own money. This behavioral bias influences human behavior in future decision-making. This review examines the implications of the house money effect on an individual investors financial decision-making. Our study adopts a systematic review approach to understand and extensively synthesize the existing literature. The study considered 34 articles from the Scopus database. The study provides an overview of the literature regarding theories, methodology, research opportunities, and developments in the house money effect. The study points out the situational factors influencing the house money effect and the association of the bias with other behavioral biases. This review identifies the gaps in the literature and provides directions for future research to deepen the understanding of the effect of house money on individual investors. This study builds a strong framework for future research. The Author(s), under exclusive license to Springer Nature Switzerland AG 2024. -
Understanding the emerging integrated marketing communication strategies used in marketing Tamil films /
IOSR Journal Of Humanities And Social Science, Vol.21, Issue 2, Ver. V, pp.33-37, ISSN: e-ISSN: 2279-0837, p-ISSN: 2279-0845. -
Understanding the developmental relevance of animated cartoons: How people perceive the United Nations productions /
The mass media has emerged as one of the greatest tools and a catalyst in propelling some of the great changes in the society. Animated cartoon is one of the forms of mass media. Although often understated, mildly acknowledged and subtle in its ways, it holds the potential to make positive changes if used optimally. -
Understanding the business model of private equity & comparative analysis of emerging economics & developed economics
Research Revolution Vol.1, Issue 6,pp.18-20 ISSN No. 2319-300X -
Understanding the antecedents of service decisions: An integration of service promiscuity and customer citizenship behaviour
Promiscuity being casual and unrestrained towards any kind of service, the purpose of this article is to contribute to service literature by investigating the influence of customer citizenship behaviour and service promiscuity in the decision-making process in the context of public house services. This paper empirically draws a historic sum-up on the roots of service promiscuity towards the decision-making process. A questionnaire was administered to 1,509 pub customers using retrospective experience sampling technique. The proposed hypotheses were tested using structural equation modelling. Results from this research yielded novel insights into the dual antecedents extending to customer decision making process through customer citizenship behaviour and service promiscuity. The findings have implications for the ongoing argumentation on the practicality of customer promiscuity, thereby broadening the theoretical understanding of 'why customers' decision-making process establishes such an efficacious effect in the service environment? Further, these new and interesting results enlighten the insights of consumer behaviour and more importantly contribute substantially to the existing knowledge of service marketing literature. The results provide managers with specific decision-making process variables and substantial service strategies. 2019 Inderscience Enterprises Ltd. -
Understanding stigma and burnout among HIV/ AIDS health care workers Implications for counselling
The article examines the association between burnout and stigma among Health Care Workers (HCWs) and highlights the need for counselling services in the care of the HCWs. Stereotypes of HIV/AIDS and burnout in HCWs caring for people living with HIV/AIDS (PLHIV) were assessed using self-report methods. Stereotypes about AIDS Scale (SAAS) and Maslach Burnout Inventory MBI were completed by 120 staff from 8 community care centres for PLHIV across south India. Results of SAAS showed that about 33 percent respondents manifested high level of stigma while 35 percent exhibited moderate levels. The results of MBI showed high level of burnout in about 31 percent and moderate in 35 percent respondents. -
Understanding Startup Valuation and its Impact on Startup Ecosystem
Startups play a substantial role in the economic growth of a nation, by introducing new technologies, ground-breaking innovation, creating jobs, etc. A couple of decades back, it was extremely difficult to start a business, but today new businesses pop up every day, all around the world. Recognizing the importance of a startup, governments across the globe are doing their best to provide an atmosphere where startups can bloom. Despite its importance and all the support, the startup failure rate is at 90%; about 10% of startups fail in the first year and 70% fail in two to five years. The startup boom saw the emergence of alternative sources of funding like Venture Capitalist, Angel Investors, etc. These investors (Venture Capitalist, Angel Investors, etc.) played a crucial role in startup success by providing easy access to funds which is a critical and scarce resource for any founder. Traditionally business success is linked with sustainable profitability but in the startup world most used method to define success is valuation. Based on CB Insights research, as of January 2022, there are more than 900 unicorns (startup with a valuation of over $1 billion) around the world and of these unicorns less than 10% are profitable. It's difficult to explain/comprehend how startups' which are neither profitable nor foresee profitability in near future are valued higher than traditional business with stable profitability. Current valuation methods have impacted the startup ecosystem. Today, founders start their business with exit in mind, the focus of founders is on growth/scale rather than profitability. There is a school of thought that believes that such valuations will soon result in the bursting of the startup bubble just like the dotcom bubble seen in late 1990s. The focus of this paper is to investigate the techniques used by investors for startup valuation and how these techniques are impacting the startup ecosystem and its founders. The paper looks at all stages of the investment cycle, from seed to IPO or takeover and understands the process of valuation at each stage and how it impacts all stakeholders in the ecosystem. 2022 Walter de Gruyter GmbH, Berlin/Boston. -
Understanding Peer Victimisation and Related Coping Strategies Among Young Adults
Peer victimisation is a term used to describe the process of an individual being bullied by other peers, physically as well as socially, which affects the victims personality, emotional functioning, behaviour, and well-being. In response, the victims adopt several coping strategies to deal with the situation. However, the experience makes an indelible mark on those who have been victims of the process. This current study aims to understand the perspectives of young adults who have experienced peer victimisation and also explore the coping strategies used by them. The study adopts a qualitative research design, based on which data was collected from young adults (n = 10) using semi-structured interviews. After a process of screening, participants were chosen using a purposive sampling method. The data collected was analysed using Interpretative Phenomenological Analysis (IPA), through which various super-ordinate themes emerged. The significant themes focus on the nature of peers, experiences of peer victimisation, risk factors leading to peer victimisation, consequences of peer victimisation, coping mechanisms, and strategies to prevent peer victimisation. The findings highlight the understanding of the repercussions of peer victimisation and emphasise the need to adopt innovative strategies, implement pre-emptive interventions, and mandate decisive measures to mitigate instances of peer victimisation. The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. -
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Understanding Nonsense Verse : A Study of Select Works of Sukumar Ray
Among all the literary genres created and cultivated over the ages, Nonsense verse newlineperhaps emerges as one of the most challenging to comprehend. Nonsense verse often employs subversion (language, syntax, logic, etc.) as its tool and usually leaves the readers in a state of confusion. A look into the limericks of Edward Lear would bear newlinetestimony to this fact. For readers and researchers, the quest for meaning has newlineunravelled many literary and philosophical pursuits. One such possibility, therefore, newlinecould be the attempt to comprehend and critically analyse the unique literary genre newlinetermed Nonsense verse. From the multiple understandings and debatable definitions newlineof verse forms, one striking and rare genre evolves into nonsense poetry. Following newlinethe cue, this thesis purports to seek sense and meaning from what is labelled newline nonsense . It depicts that the functionality of existing, creative stylistics in language newlineand understanding and the text s contextual placement bring out the sense in nonsense. As Edward Lear mastered this art form in the West, Sukumar Ray crafted this genre in India, though he was not the only one. The thesis traces the evolution of nonsense verse in India, literary and folk, to understand the possible functionality of this genre as it exists in India. As the study shows, the writer who made the most contributions to this evolution was Sukumar Ray. Therefore, understanding the evolution and function of Indian nonsense verse become the object of the study, and an in-depth, contextual study of the select poems of Sukumar Ray, the national pioneering writer of nonsense, becomes the subject. This research attempts to unearth a fresh approach to re-evaluating the function of nonsense verse and possibly confer upon it a more considerable eminence. The thesis aims to provide comprehension and newlinecredibility to the genre through the study of select works of Sukumar Ray. -
Understanding neurodiversity and mindfulness: A holistic approach to addiction in professional preparation programs
This chapter explores the interplay between neurodiversity, mindfulness, and addiction, emphasizing their incorporation into professional preparation programmes. Neurodiverse individuals, who exhibit various neurological characteristics, may encounter unique obstacles that make them more prone to addiction. The chapter begins by examining the unique challenges and requirements of neurodiverse individuals who may be at increased risk for addiction. The chapter advocates for incorporating mindfulness practises into programmes of professional preparation. It discusses how neurodiverse individuals can be introduced to mindfulness practises centred on present-moment awareness and the non-judgmental observation of thoughts and emotions as a valuable tool for addiction recovery. This chapter concludes by highlighting the importance of addressing the unique requirements of neurodiverse individuals in addiction recovery by incorporating mindfulness into professional preparation programmes. 2024, IGI Global. All rights reserved. -
Understanding magic realism in regional cinema: A content analysis of selected Malayalam films /
Magic Realism, was introduced in Latin America as an expression of the blend of realist and magical views of life in the perspective of the conflicting cultures of Latin America expressed through its art and literature, but later it was adopted as a term used to refer to all narrative fiction that includes magical events in a realistic matter-of-fact narrative, where, the unordinary or supernatural is not a plain or evident matter, but it is an ordinary matter, which can happen every day. -
Understanding Labor Market Dynamics in Urban India Amidst the Pandemic: A Study Employing Supervised Learning Methods
This study provides insights into the dynamic job ladder and challenges in the Indian labor market, particularly when facing external shock. It examines the fluidity of job transitions among the employed, unemployed, and those not in the laborforce, focusing on the urban labor market of India during the COVID-19 pandemic. Using data from the 2020-21 Periodic Labour Force Survey, a longitudinal panel dataset was created to track individuals across four quarters, enabling the monitoring of their activity status. Employing K-Nearest Neighbour classification, the study identifies vulnerabilities in labor market engagement. It further explores factors driving transitions among the three states of labor market involvement, using a multinomial logistic model adjusted for selection bias. The research reveals significant movement within the labor force, with notable shifts between employment statuses. Even those currently employed are often vulnerable, at risk of detachment from the labor force at any time. Women were disproportionately affected, with evidence of discouraged worker effect, as many ceased jobs search duo to perceived job scarcity or unavailability of decent jobs. The study raised concerns about the sustainability of self-employment and the security of regular jobs. These findings expose enduring structural challenges exacerbated by the pandemic, calling for urgent action to address widespread unemployment, low female participation, and prevailing inequalities in the labor market. The Author(s), under exclusive licence to The Indian Econometric Society 2024. -
Understanding inhibitors to XBRL adoption: an empirical investigation
Purpose: This study aims to investigate the awareness of extensible business reporting language (XBRL) and the perception of chartered accountants of India concerning the inhibitors of XBRL adoption, namely, environmental, organizational and innovation factors developed by Troshani and Rao (2007) from Rogers innovation diffusion theory. In addition, the analysis also investigated the relationship between the perception of issues regarding XBRL adoption and individual characteristics (training, age, gender and professional experience). Design/methodology/approach: A Web-based questionnaire was circulated through e-mail to chartered accountants registered with the Institute of Chartered Accountants India (ICAI) and 233 chartered accountants responded to the questionnaire. The data was analyzed using reliability statistics and multivariate regression analyses. Findings: The results indicate that accountants perceived that environmental, organizational and innovational factors were challenging in adopting XBRL. Interestingly, training and experience were significant factors in explaining respondents perceptions. Practical implications: From a practical panorama, the significance of issues implies that associations such as XBRL International, XBRL India, ICAI and the Ministry of Corporate Affairs should collectively take the appropriate steps to sustain and ameliorate the reliability and adoption of XBRL. Social implications: The results can motivate ICAI/Institute of Company Secretaries of India (ICSI) courses to teach academic content about XBRL. Originality/value: The present study differs from previous research because it examines the inhibitors in adopting XBRL, namely, environmental, organizational and innovation factors, in an empirical setting. Moreover, to the best of the authors knowledge, this is the first study to analyze the influence of individual factors on accountants perceptions about inhibitors of XBRL adoption. 2021, Emerald Publishing Limited.