Efficient one-pot green synthesis of carboxymethyl cellulose/folic acid embedded ultrafine CeO2 nanocomposite and its superior multi-drug resistant antibacterial activity and anticancer activity
- Title
- Efficient one-pot green synthesis of carboxymethyl cellulose/folic acid embedded ultrafine CeO2 nanocomposite and its superior multi-drug resistant antibacterial activity and anticancer activity
- Creator
- Boopathi T.S.; Rajiv A.; Patel T.S.G.M.; Bareja L.; Salmen S.H.; Aljawdah H.M.; Arulselvan P.; Suriyaprakash J.; Thangavelu I.
- Description
- Due to the prevalence of drug-resistant bacteria and the ongoing shortage of novel antibiotics as well as the challenge of treating breast cancer, the therapeutic and clinical sectors are consistently seeking effective nanomedicines. The incorporation of metal oxide nanoparticles with biological macromolecules and an organic compound emerges as a promising strategy to enhance breast cancer treatment and antibacterial activity against drug-resistant bacteria in various biomedical applications. This study aims to synthesize a unique nanocomposite consisting of CeO2 embedded with folic acid and carboxymethyl cellulose (CFC NC) via a green precipitation method using Moringa oleifera. Various spectroscopic and microscopic analyses are utilized to decipher the physicochemical characteristics of CFC NC and active phytocompounds of Moringa oleifera. Antibacterial study against MRSA (Methicillin-resistant Staphylococcus aureus) demonstrated a higher activity (95.6%) for CFC NC compared to its counterparts. The impact is attributed to reactive oxygen species (ROS), which induces a strong photo-oxidative stress, leading to the destruction of bacteria. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of CFC NC are determined as 600g/mL and 1000g/mL, respectively. The anticancer activity against breast cancer cell resulted in the IC50 concentration of 10.8?g/mL and 8.2?g/mL for CeO2 and CFC NC respectively.The biocompatibility test was conducted against fibroblast cells and found 85% of the cells viable, with less toxicity. Therefore, the newly synthesized CFC NC has potential applications in healthcare and industry, enhancing human health conditions. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
- Source
- Bioprocess and Biosystems Engineering
- Date
- 2024-01-01
- Publisher
- Springer Science and Business Media Deutschland GmbH
- Subject
- Antibacterial activity; Biocompatibility; Carboxymethyl cellulose; CeO2; Folic acid
- Coverage
- Boopathi T.S., Department of Chemistry, Amrita School of Physical Sciences, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India, Functional Materials Laboratory, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India; Rajiv A., Department of Physics, Faculty of Sciences, JAIN (Deemed-to-Be University), Karnataka, Bangalore, 562112, India; Patel T.S.G.M., Department of Community Medicine, Parul University, Gujarat, PO Limda, Tal. Waghodia, Vadodara, 391760, India; Bareja L., Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, 140417, India; Salmen S.H., Department of Botany and Microbiology, College of Science, King Saud University, PO Box-2455, Riyadh, 11451, Saudi Arabia; Aljawdah H.M., Department of Zoology, College of Science, King Saud University, PO Box-2455, Riyadh, 11451, Saudi Arabia; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Tamil Nadu, Chennai, 602 105, India; Suriyaprakash J., Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter, Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, China; Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Karnataka, Bangalore, 560029, India
- Rights
- Restricted Access
- Relation
- ISSN: 16157591; PubMed ID: 39503917; CODEN: BBEIB
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Boopathi T.S.; Rajiv A.; Patel T.S.G.M.; Bareja L.; Salmen S.H.; Aljawdah H.M.; Arulselvan P.; Suriyaprakash J.; Thangavelu I., “Efficient one-pot green synthesis of carboxymethyl cellulose/folic acid embedded ultrafine CeO2 nanocomposite and its superior multi-drug resistant antibacterial activity and anticancer activity,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/13448.