Amyotrophic Lateral Sclerosis: Insights and New Prospects in Disease Pathophysiology, Biomarkers and Therapies
- Title
- Amyotrophic Lateral Sclerosis: Insights and New Prospects in Disease Pathophysiology, Biomarkers and Therapies
- Creator
- Al-Khayri J.M.; Ravindran M.; Banadka A.; Vandana C.D.; Priya K.; Nagella P.; Kukkemane K.
- Description
- Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disorder marked by the gradual loss of motor neurons, leading to significant disability and eventual death. Despite ongoing research, there are still limited treatment options, underscoring the need for a deeper understanding of the diseases complex mechanisms and the identification of new therapeutic targets. This review provides a thorough examination of ALS, covering its epidemiology, pathology, and clinical features. It investigates the key molecular mechanisms, such as protein aggregation, neuroinflammation, oxidative stress, and excitotoxicity that contribute to motor neuron degeneration. The role of biomarkers is highlighted for their importance in early diagnosis and disease monitoring. Additionally, the review explores emerging therapeutic approaches, including inhibitors of protein aggregation, neuroinflammation modulators, antioxidant therapies, gene therapy, and stem cell-based treatments. The advantages and challenges of these strategies are discussed, with an emphasis on the potential for precision medicine to tailor treatments to individual patient needs. Overall, this review aims to provide a comprehensive overview of the current state of ALS research and suggest future directions for developing effective therapies. 2024 by the authors.
- Source
- Pharmaceuticals, Vol-17, No. 10
- Date
- 2024-01-01
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Subject
- amyotrophic lateral sclerosis; diagnosis; neuroinflammation; pathology; therapies
- Coverage
- Al-Khayri J.M., Department of Agricultural Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa 31982, Saudi Arabia; Ravindran M., Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed-to-be-University), Bangalore, 560027, India; Banadka A., Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed-to-be-University), Bangalore, 560027, India; Vandana C.D., Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed-to-be-University), Bangalore, 560027, India; Priya K., Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed-to-be-University), Bangalore, 560027, India; Nagella P., Department of Life Sciences, School of Sciences, Christ University, Bengaluru, 560029, India; Kukkemane K., Department of Life Sciences, School of Sciences, Christ University, Bengaluru, 560029, India
- Rights
- All Open Access; Gold Open Access
- Relation
- ISSN: 14248247
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Al-Khayri J.M.; Ravindran M.; Banadka A.; Vandana C.D.; Priya K.; Nagella P.; Kukkemane K., “Amyotrophic Lateral Sclerosis: Insights and New Prospects in Disease Pathophysiology, Biomarkers and Therapies,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/21274.