ItemArticle

Biocompatible Sodium Alginate Modified BaO2H2O2 Nanoparticles With Improved Therapeutic Efficacy Against Multidrug-Resistant Pathogens and Cancer Cells

Title
Biocompatible Sodium Alginate Modified BaO2H2O2 Nanoparticles With Improved Therapeutic Efficacy Against Multidrug-Resistant Pathogens and Cancer Cells
Creator
Nanda, Binita; Lakshmi, Chaitanya; Pandey, Chandra Mouli; Kumar, Ashwini; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A.
Description
The increasing problem of multidrug-resistant pathogens and the limitations of conventional therapies for cancer treatments require designing new therapeutic agents. BaO2H2O2 and BaSA nanoparticles were prepared and characterized to determine their antimicrobial, antifungal, and anticancer activities. The XRD confirmed the crystallite sizes to be 34 nm for BaO2H2O2 and 25 nm for BaSA. The UVvisible analysis confirmed the band gap energies as 4.13 and 4.11 eV for BaO2H2O2 and BaSA, respectively. A shift in the blue-green PL emission from 488510 nm in BaO2H2O2 to 535 nm in BaSA indicated increased oxygen vacancies. EDAX analysis demonstrated elemental variations due to SA modification, whereas DLS measurements showed a decrease in the mean size of the nanoparticles from 116.70 nm (BaO2H2O2) to 111.90 nm (BaSA). Antimicrobial activity was shown against Klebsiella pneumoniae, Shigella dysenteriae, Escherichia coli, Pseudomonas aeruginosa, and Proteus vulgaris, while a considerable enhancement of antifungal activity against Candida albicans was observed in BaSA. Against MG-63 osteosarcoma cells, BaSA exhibited lower IC50 values (21.5, 20.2, 18.7 ?g mL?1 at 24, 48, and 72 h) when compared with BaO2H2O2 (23.4, 22.5, 21.3 ?g mL?1). Zebrafish embryos tolerated BaSA at 0.5 mg mL?1, with developmental abnormalities observed only at 1.0 mg mL?1. 2025 John Wiley & Sons Ltd.
Source
Polymers for Advanced Technologies;Volume;36;Issue;10;Article No.;e70363;
Date
01-01-2025
Publisher
John Wiley and Sons Ltd
Subject
antibacterial; anticancer; antifungal; barium peroxide; SA; surface modification
Coverage
Nanda B., Department of Chemistry, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, India; Lakshmi C., Department of Chemistry, Presidency University, Bengaluru, India; Pandey C.M., Department of Chemistry, Faculty of Applied and Basic Sciences, SGT University, Gurgaon, India; Kumar A., Department of Mechanical, ARKA JAIN University, Jamshedpur, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 10427147;
Format
online
Language
English
Type
Article

Citation

Nanda, Binita; Lakshmi, Chaitanya; Pandey, Chandra Mouli; Kumar, Ashwini; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A., “Biocompatible Sodium Alginate Modified BaO2H2O2 Nanoparticles With Improved Therapeutic Efficacy Against Multidrug-Resistant Pathogens and Cancer Cells,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/21793.

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