ItemArticle

Pluronic F127 and Dopamine Functionalized Fe2O3 Nanocomposites: A Multifunctional Polymer-Based Platform for Anticancer, Antibacterial, and Antioxidant Applications

Title
Pluronic F127 and Dopamine Functionalized Fe2O3 Nanocomposites: A Multifunctional Polymer-Based Platform for Anticancer, Antibacterial, and Antioxidant Applications
Creator
Borah, Nayana; Ganesan, Subbulakshmi; Singh, Manpreet; Srivastava, Nidhi; Thangavelu, Indumathi; Bhran, Ahmed A.; Tadepalli, Srinivas
Description
Cancer, bacterial infections, and oxidative stress continue to pose serious global health challenges, necessitating the development of multifunctional therapeutic agents. Iron oxide (Fe2O3) nanoparticles were selected as the core material owing to their intrinsic biocompatibility, redox activity, and established biomedical relevance. To overcome the limitations of particle aggregation and poor solubility, pluronic F127 (a biocompatible triblock copolymer) was employed as a stabilizer, while dopamine was introduced as a surface modifier to enhance functionalization, improve dispersion, and facilitate cellular uptake. The resulting Fe2O3-PF127-DOP nanocomposites were thoroughly characterized using XRD, FTIR, SEM, TEM, PL, and XPS analyses, confirming successful functionalization and enhanced stability. Antioxidant assays revealed 79.24% activity at 20 ?g/mL, comparable to Vitamin C, highlighting its antioxidant activity. Antibacterial studies against multiple pathogenic strains, including Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Shigella dysenteriae, and Vibrio cholerae, showed markedly larger inhibition zones for Fe2O3-PF127-DOP than for Fe2O3, confirming its broad-spectrum antibacterial potential. Fe2O3-PF127-DOP exhibited superior cytotoxicity against HCT-116 colon cancer cells (IC50 = 15.3 ?g/mL) compared to Fe2O3 (IC50 = 17.2 ?g/mL), attributed to improved uptake and ROS-mediated apoptosis. Importantly, cytocompatibility studies on L929 fibroblast cells revealed high cell viability of 83% and 86% for Fe2O3 and Fe2O3-PF127-DOP, respectively, demonstrating the nanocomposite's biocompatibility. Overall, this study demonstrates that strategic functionalization of Fe2O3 with pluronic F127 and dopamine yields a stable, multifunctional nanocomposite with significant anticancer, antioxidant, and antibacterial applications. 2025 John Wiley & Sons Ltd.
Source
Polymers for Advanced Technologies;Volume;36;Issue;11;Article No.;e70413;
Date
01-01-2025
Publisher
John Wiley and Sons Ltd
Subject
antibacterial activity; anticancer activity; antioxidant activity; biomedical applications; Fe2O3-PF127-DOP nanocomposites; HCT-116 colon cancer cells; reactive oxygen species
Coverage
Borah N., Department of Life Sciences, School of Sciences, JAIN (Deemed-To-Be University), Karnataka, India; Ganesan S., Department of Chemistry and Biochemistry, JAIN (Deemed-To-Be University), Karnataka, Bangalore, India; Singh M., Center of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, India; Srivastava N., Maharishi School of Pharmaceutical Sciences, Maharishi University of Information Technology, Uttar Pradesh, Lucknow, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Bangalore, India; Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 10427147;
Format
online
Language
English
Type
Article

Citation

Borah, Nayana; Ganesan, Subbulakshmi; Singh, Manpreet; Srivastava, Nidhi; Thangavelu, Indumathi; Bhran, Ahmed A.; Tadepalli, Srinivas, “Pluronic F127 and Dopamine Functionalized Fe2O3 Nanocomposites: A Multifunctional Polymer-Based Platform for Anticancer, Antibacterial, and Antioxidant Applications,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/21794.

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