ItemArticle

Biogenic Carboxymethyl Cellulose and L-Histidine Coated Barium Peroxide Nanocomposite: A Tri-Functional Platform Targeting Antimicrobial Resistance, Cancer, and Oxidative Stress

Title
Biogenic Carboxymethyl Cellulose and L-Histidine Coated Barium Peroxide Nanocomposite: A Tri-Functional Platform Targeting Antimicrobial Resistance, Cancer, and Oxidative Stress
Creator
Tadepalli, Srinivas; Rathore, Mahendra Singh; Ballal, Suhas; Thangavelu, Indumathi; Gadallah, Abdelrahman G.
Description
The study addresses the urgent need for novel therapeutic agents in combating multidrug-resistant pathogens, cancer, and oxidative stress-related diseases. Barium peroxide (BaO2) nanoparticles and its novel nanocomposite, carboxymethyl cellulose and L-histidine coated BaO2 (BaO2-CMC-LH) were synthesized, characterized, and evaluated for their antibacterial, anticancer, and DPPH radical scavenging activities. Structural and functional characterizations were carried out using various analytical techniques. Biological evaluations demonstrated enhanced antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans (C. albicans), with BaO2-CMC-LH exhibiting superior inhibition zones compared to BaO2. For MRSA, the zone of inhibition (ZOI) for BaO2 is about 9 mm, whereas the BaO2-CMC-LH nanocomposite exhibits a substantially larger ZOI of 21 mm. Likewise, for C. albicans, BaO2 presents a ZOI of 12 mm, and BaO2-CMC-LH exhibits a greater inhibition zone of 18 mm. Cytotoxicity analysis against osteosarcoma MG-63 cells revealed significantly improved anticancer activity, with BaO2-CMC-LH achieving an IC?? value of 28.6 ?g/mL compared to 53.3 ?g/mL for BaO2. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay showed that the BaO2-CMC-LH nanocomposite (78.45%) had activity compared to BaO2 alone (64.43%). These findings underscore the synergistic effects of the CMC-LH matrix in enhancing BaO2's biological activities, positioning BaO2-CMC-LH as a promising multifunctional therapeutic agent for addressing global health challenges. 2026 John Wiley & Sons Ltd.
Source
Polymers for Advanced Technologies;Volume;37;Issue;1;Article No.;e70508;
Date
01-01-2026
Publisher
John Wiley and Sons Ltd
Subject
barium peroxide; Candida albicans; carboxymethyl cellulose; DPPH free radical scavenging assay; L-histidine; MRSA; osteosarcoma MG-63
Coverage
Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; Rathore M.S., Department of Applied Science, PIT, Parul University, Gujarat, Vadodara, India; Ballal S., Department of Biochemistry, School of Sciences, JAIN (Deemed-to-be University), Karnataka, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India; Gadallah A.G., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia
Rights
All Open Access; Bronze Open Access
Relation
ISSN: 10427147;
Format
online
Language
English
Type
Article

Citation

Tadepalli, Srinivas; Rathore, Mahendra Singh; Ballal, Suhas; Thangavelu, Indumathi; Gadallah, Abdelrahman G., “Biogenic Carboxymethyl Cellulose and L-Histidine Coated Barium Peroxide Nanocomposite: A Tri-Functional Platform Targeting Antimicrobial Resistance, Cancer, and Oxidative Stress,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/21795.

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