ItemArticle

Pluronic F127Folic Acid Modified Nickel Oxide Nanocomposites via a Facile One-Pot Approach for InVitro Anticancer, Antibacterial, and DPPH Radical Scavenging Studies

Title
Pluronic F127Folic Acid Modified Nickel Oxide Nanocomposites via a Facile One-Pot Approach for InVitro Anticancer, Antibacterial, and DPPH Radical Scavenging Studies
Creator
Gadallah, Abdelrahman G.; Thangavelu, Indumathi; Tadepalli, Srinivas; Arulselvan, Palanisamy
Description
Drug-resistant bacteria and cancer remain major challenges in healthcare, highlighting the need for multifunctional nanomaterials. In this study, folic acid- and Pluronic F127-modified nickel oxide nanocomposites (NiOPF127FA) were synthesized via a one-pot method, and their invitro antibacterial, antioxidant, and anticancer properties were evaluated. XRD analysis showed a crystallite size of 19.42 nm for NiOPF127FA, while PL spectra exhibited a green emission peak at 507 nm, indicative of structural defects in the NiO lattice. NiOPF127FA displayed enhanced antibacterial activity against MRSA and Candida albicans compared to bare NiO, as evidenced by larger inhibition zones and lower MIC and MBC values. The DPPH assay demonstrated improved radical scavenging activity of the modified nanocomposites, likely related to their smaller size, higher surface area, and surface defect-mediated electron transfer. Invitro anticancer studies using rat C6 glioblastoma cells revealed dose-dependent decreases in cell viability, with IC50 values of 12.3 ?g/mL for NiO and 9.6 ?g/mL for NiOPF127FA. Fluorescence staining with AO/EB and DAPI indicated morphological changes in nuclei and alterations in MMP, consistent with induction of cell death. Overall, these findings suggest that NiOPF127FA nanocomposites exhibit improved invitro biological activity, providing a foundation for further preclinical investigations of their potential biomedical applications. 2026 John Wiley & Sons Ltd.
Source
Polymers for Advanced Technologies;Volume;37;Issue;2;Article No.;e70531;
Date
01-01-2026
Publisher
John Wiley and Sons Ltd
Subject
antimicrobial activity; apoptosis; glioma cancer; mitochondrial membrane potential; NiO; NiO-PF 127-FA
Coverage
Gadallah A.G., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; Thangavelu I., Department of Chemistry, CHRIST (Deemed To Be University), Bangalore, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; Arulselvan P., Department of Biochemistry, Karpagam Academy of Higher Education (Deemed to be University), Tamil Nadu, Coimbatore, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 10427147;
Format
online
Language
English
Type
Article

Citation

Gadallah, Abdelrahman G.; Thangavelu, Indumathi; Tadepalli, Srinivas; Arulselvan, Palanisamy, “Pluronic F127Folic Acid Modified Nickel Oxide Nanocomposites via a Facile One-Pot Approach for InVitro Anticancer, Antibacterial, and DPPH Radical Scavenging Studies,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 18, 2026, https://archives.christuniversity.in/items/show/21797.

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