ItemArticle

Biocompatible Pluronic F127-coated nickel titanate nanoparticles: toward effective antimicrobial and antioxidant therapies

Title
Biocompatible Pluronic F127-coated nickel titanate nanoparticles: toward effective antimicrobial and antioxidant therapies
Creator
Thangavelu, Indumathi; Tadepalli, Srinivas; Boopathi, Thalakulam Shanmugam
Description
Multidrug-resistant bacterial infections are a major global health concern. Nickel titanate (NiTiO?) nanoparticles offer potential antimicrobial applications, but their biocompatibility is limited. This study explores the surface modification of NiTiO? with Pluronic F127 (PF127) to enhance biological performance. NiTiO? nanoparticles were synthesized and coated with PF127. Characterization was performed using XRD, FTIR, HRTEM, BET and DLS. Antibacterial activity was assessed via pathogenic bacteria assays and colony-forming unit quantification. Antioxidant activity was measured using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and zebrafish embryos evaluated in vivo toxicity. XRD confirmed hexagonal NiTiO?, and FTIR/HRTEM verified PF127 incorporation. BET analysis indicated a surface area of 28.66 m2 g?1 and mesoporous structure (2.59 nm pore diameter). DLS showed particle size reduction from 219.3 nm (NiTiO?) to 135.9 nm (NiTiO?PF127), confirming improved dispersion. NiTiO?PF127 exhibited enhanced antibacterial activity, with colony-forming unit counts decreasing in a concentration-dependent manner. The DPPH assay showed 53.7% radical scavenging at 20 ?g mL?1. Zebrafish embryo studies revealed higher viability and lower developmental toxicity for PF127-coated nanoparticles compared to uncoated NiTiO?. PF127 modification of NiTiO? improves dispersion, antibacterial and antioxidant activity, and biocompatibility. These results highlight NiTiO?PF127 nanocomposite as a promising candidate for biomedical and antimicrobial applications. 2026 Society of Chemical Industry. 2026 Society of Chemical Industry.
Source
Polymer International;
Date
01-01-2026
Publisher
John Wiley and Sons Ltd
Subject
antibacterial activity; biocompatibility; nanocomposite; NiTiO? nanoparticles; Pluronic F127; zebrafish embryo model
Coverage
Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; Boopathi T.S., Department of Chemistry, Amrita School of Physical Sciences Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, India, Functional Materials Laboratory, Amrita School of Engineering Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, India
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 9598103;
Format
online
Language
English
Type
Article

Citation

Thangavelu, Indumathi; Tadepalli, Srinivas; Boopathi, Thalakulam Shanmugam, “Biocompatible Pluronic F127-coated nickel titanate nanoparticles: toward effective antimicrobial and antioxidant therapies,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 19, 2026, https://archives.christuniversity.in/items/show/21798.

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