ItemArticle

Synthesis and characterization of SnO2-SA-FA nanocomposite for anticancer (cervical cancer HeLa cells), antimicrobial (methicillin-resistant Staphylococcus aureus, Candida albicans) and antioxidant activities

Title
Synthesis and characterization of SnO2-SA-FA nanocomposite for anticancer (cervical cancer HeLa cells), antimicrobial (methicillin-resistant Staphylococcus aureus, Candida albicans) and antioxidant activities
Creator
Choudhary, Binod Kr; Achary, Patnala Ganga Raju; Devakki, Basavaraj; Kapoor, Shalini; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A
Description
This study reports the synthesis and characterization of a novel sodium alginate (SA) and folic acid (FA) functionalized tin oxide nanocomposite (SnO2-SA-FA) and investigates its antimicrobial, antioxidant and anticancer properties. XRD analysis confirmed the tetragonal crystalline structure of SnO2, while the crystallite size decreased from 28.3 nm for pure SnO2 to 22.1 nm after functionalization, indicating enhanced surface area and reactivity. UVvisible analysis revealed a reduction in bandgap energy from 3.6 to 3.4 eV, suggesting improved charge transfer capability. Photoluminescence studies showed green emission at 506 nm, indicating enhanced oxygen vacancy defects and reactive oxygen species (ROS) generation. The SnO2-SA-FA nanocomposite demonstrated enhanced antimicrobial activity against methicillin-resistant Staphylococcus aureus and Candida albicans, exhibiting zones of inhibition of 20 mm and 17 mm, respectively, with minimum bactericidal concentration values of 1600 ?g mL?1. Antioxidant studies revealed significantly improved 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity, reaching 83.23% at 100 ?g mL?1 compared to 66.34% for pure SnO? nanoparticles. Cytotoxicity studies against HeLa cervical cancer cells demonstrated dose-dependent anticancer activity, with the SnO2-SA-FA nanocomposite exhibiting a lower IC50 value (concentration required to inhibit 50% of cell viability) (40.6 ?g mL?1) than pure SnO? nanoparticles (58.2 ?g mL?1). Fluorescence microscopy confirmed enhanced apoptosis induction through ROS-mediated oxidative stress and folate-receptor-targeted uptake. Furthermore, biocompatibility studies on L929 fibroblast cells showed cell viability above 80%, confirming low toxicity and favorable biological safety. These findings demonstrate that the SnO2-SA-FA nanocomposite is a promising multifunctional nanoplatform for antimicrobial, antioxidant and targeted anticancer biomedical applications. 2026 Society of Chemical Industry. 2026 Society of Chemical Industry.
Source
Polymer International;
Date
01-01-2026
Publisher
John Wiley and Sons Ltd
Subject
antimicrobial activity; antioxidant activity; cervical cancer; folic acid; SnO2 nanoparticles; sodium alginate
Coverage
Choudhary B.K., Department of Mechanical, ARKA JAIN University, Jamshedpur, India; Achary P.G.R., Department of chemistry, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, India; Devakki B., Department of Mechanical Engineering, Presidency University, Bengaluru, India; Kapoor S., Department of Periodontology, Faculty of Dental Sciences, SGT University, Gurugram, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; Bhran A.A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia
Rights
Restricted Access; Hardcopy may be available in the library
Relation
ISSN: 9598103;
Format
online
Language
English
Type
Article

Citation

Choudhary, Binod Kr; Achary, Patnala Ganga Raju; Devakki, Basavaraj; Kapoor, Shalini; Thangavelu, Indumathi; Tadepalli, Srinivas; Bhran, Ahmed A, “Synthesis and characterization of SnO2-SA-FA nanocomposite for anticancer (cervical cancer HeLa cells), antimicrobial (methicillin-resistant Staphylococcus aureus, Candida albicans) and antioxidant activities,” CHRIST (Deemed To Be University) Institutional Repository, accessed June 19, 2026, https://archives.christuniversity.in/items/show/21799.

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